Abstract:
:Oral naltrexone reduces heavy drinking, but is less consistent as an abstinence promoter, whereas once-monthly extended-release naltrexone (XR-NTX) also maintains abstinence. The present study sought to determine if alcohol cue reactivity is attenuated by XR-NTX. Twenty-eight detoxified alcohol-dependent adult male and female volunteers received a single i.m. injection of either XR-NTX or placebo under double-blind conditions. An fMRI/cue reactivity procedure was conducted immediately before and two weeks after injection. At baseline, alcohol-related visual and olfactory cues elicited significant increases in orbital and cingulate gyri, inferior frontal and middle frontal gyri. Subsequently, brain activation was significantly altered in XR-NTX-treated individuals. These affected brain regions are associated with the integration of emotion, cognition, reward, punishment, and learning/memory, suggesting that XR-NTX attenuates the salience of alcohol-related cues. Such an effect on brain function may interrupt the processes associated with "slips" and relapse, which may account for XR-NTX's ability to maintain abstinence.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Lukas SE,Lowen SB,Lindsey KP,Conn N,Tartarini W,Rodolico J,Mallya G,Palmer C,Penetar DMdoi
10.1016/j.neuroimage.2013.03.055subject
Has Abstractpub_date
2013-09-01 00:00:00pages
176-85eissn
1053-8119issn
1095-9572pii
S1053-8119(13)00305-4journal_volume
78pub_type
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