Abstract：
:Anatomical and functional MRI images were acquired in a group of healthy elderly subjects (n = 11) and a group of patients diagnosed with probable Alzheimer's disease, from mild to moderate severity (n = 8). During functional sessions, verbal episodic Encoding and Recognition tasks were presented to subjects. Both groups were compared in terms of gray matter volume and cerebral activation. Furthermore, in the AD group, correlations between hippocampal gray matter volume and whole-brain activations were examined. When compared to healthy controls, AD patients presented significant gray matter atrophy as well as reduced activations during Encoding and Recognition in the medial temporal lobes and inferior parietal/superior temporal associative areas. In the same regions, the fMRI activity elicited by the Recognition task was positively correlated with hippocampal gray matter volume. Moreover, an increase of left prefrontal activity during Encoding and Recognition was observed in AD patients relative to controls and was correlated with memory performance. This additional activity elicited by episodic memory processes was not found to correlate with the degree of medial temporal atrophy in our group of patients. Our study shows that function in brain regions critical to episodic memory is altered in AD. During episodic Recognition, these functional changes may closely correlate with the progressive structural changes observed in the hippocampal region.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Rémy F,Mirrashed F,Campbell B,Richter Wdoi
10.1016/j.neuroimage.2004.10.045keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
253-66issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(04)00664-0journal_volume
25pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:Pain requires the integration of sensory, cognitive, and affective information. The use of placebo is a common methodological ploy in many fields, including pain. Neuroimaging studies of pain and placebo analgesia (PA) have yet to identify a mechanism of action. Because PA must result from higher order processes, it i...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.07.057
更新日期：2007-12-01 00:00:00
abstract：:Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperature magnetoencephalography (MEG), with a greatly increased flexibility of sensor placement...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.01.034
更新日期：2017-04-01 00:00:00
abstract：:Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memo...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.03.026
更新日期：2016-07-01 00:00:00
abstract：:Temporal connectives (before/after) give us the freedom to describe a sequence of events in different orders. Studies have suggested that 'before-initiating' sentences, in which events are expressed in an order inconsistent with their actual order of occurrence, might need additional computation(s) during comprehensio...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.11.039
更新日期：2012-02-15 00:00:00
abstract：:Accurate processing of nonvisual stimuli is fundamental to humans with visual impairments. In this population, moving sounds activate an occipito-temporal region thought to encompass the equivalent of monkey area MT+, but it remains unclear whether the signal carries information beyond the mere presence of motion. To ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.04.266
更新日期：2011-05-15 00:00:00
abstract：:A fundamental feature of the temporal organization of neural activity is phase-amplitude coupling between brain rhythms at different frequencies, where the amplitude of a higher frequency varies according to the phase of a lower frequency. Here, we show that this rule extends to brain-organ interactions. We measured b...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.08.043
更新日期：2017-02-01 00:00:00
abstract：:We argue that published results demonstrate that new insights into human brain function may be obscured by poor and/or limited choices in the data-processing pipeline, and review the work on performance metrics for optimizing pipelines: prediction, reproducibility, and related empirical Receiver Operating Characterist...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2004.07.022
更新日期：2004-01-01 00:00:00
abstract：:A new functional MRI protocol that integrates variable echo time (TE) acquisition and a block-design paradigm is proposed and evaluated with finger-tapping motor task. Simulations and experimental data show that the blood oxygenation level-dependent (BOLD) sensitivity achieved with this approach is comparable to that ...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2003.08.013
更新日期：2003-12-01 00:00:00
abstract：:In positron emission tomography (PET) studies, the detailed mapping of neuroreceptor binding is a trade-off between parametric accuracy and spatial precision. Logan's graphical approach is a straightforward way to quickly obtain binding potential values at the voxel level but it has been shown to have a noise-dependen...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.02.053
更新日期：2006-10-01 00:00:00
abstract：:Small-world organization is known to be a robust and consistent network architecture, and is a hallmark of the structurally and functionally connected human brain. However, it remains unknown if the same organization is present in directed influence brain networks whose connectivity is inferred by the transfer of info...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.11.007
更新日期：2011-02-14 00:00:00
abstract：INTRODUCTION:We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. METHOD:Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in non-psychotic rel...
journal_title：NeuroImage
pub_type： 杂志文章,meta分析
doi：10.1016/j.neuroimage.2005.05.022
更新日期：2005-10-01 00:00:00
abstract：:Breathing rate and depth influence the concentration of carbon dioxide in the blood, altering cerebral blood flow and thus functional magnetic resonance imaging (fMRI) signals. Such respiratory fluctuations can have substantial influence in studies of fMRI signal covariance in subjects at rest, the so-called "resting ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.116234
更新日期：2020-01-01 00:00:00
abstract：:Resting state functional magnetic resonance imaging (fMRI) has been used to study brain networks associated with both normal and pathological cognitive functions. The objective of this work is to reliably compute resting state network (RSN) topography in single participants. We trained a supervised classifier (multi-l...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.05.108
更新日期：2013-11-15 00:00:00
abstract：:Inferring the microstructure of complex media from the diffusive motion of molecules is a challenging problem in diffusion physics. In this paper, we introduce a novel representation of diffusion MRI (dMRI) signal from tissue with spatially-varying diffusivity using a diffusion disturbance function. This disturbance f...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.09.057
更新日期：2017-02-01 00:00:00
abstract：:Reporting white matter findings in voxel-wise neuroimaging studies typically lacks specificity in terms of brain connectivity. Therefore, the purpose of this work was to develop an approach for rapidly extracting standardized brain connectivity information for white matter regions with significant findings in voxel-wi...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117462
更新日期：2021-01-15 00:00:00
abstract：:Using the intrinsic signal optical recording technique, we reconstructed the two-dimensional pattern of stimulus-evoked neuronal activities in the auditory cortex of anesthetized and paralyzed cats. The average magnitude of intrinsic signal in response to a pure tone stimulus increased steadily as the sound pressure l...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2004.08.021
更新日期：2004-12-01 00:00:00
abstract：:Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns ('functional brain networks'), which potentially underlie different mental processes. The present study characterizes how th...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.05.060
更新日期：2019-10-01 00:00:00
abstract：:Functional imaging studies consistently support the role of the medial prefrontal cortex to be a part of a functional network of reflective self-awareness. The current study introduces a new linguistic task which (1) directly compares self-reference and other-reference, and (2) separates pre-reflective from reflective...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.01.060
更新日期：2008-08-01 00:00:00
abstract：:This paper describes the application of large deformation diffeomorphic metric mapping to cortical surfaces based on the shape and geometric properties of subregions of the superior temporal gyrus in the human brain. The anatomical surfaces of the cortex are represented as triangulated meshes. The diffeomorphic matchi...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.08.053
更新日期：2007-02-01 00:00:00
abstract：:Visual integration between target and irrelevant features leads to effects of irrelevant feature congruency (Stroop) or variation (Garner) on target classification performance. Presenting closed geometrical shapes as stimuli, we obtained Stroop and Garner effects of one part of their contour on another, in response ti...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.01.019
更新日期：2009-05-01 00:00:00
abstract：:The dynamics of the brain's intrinsic networks have been recently studied using co-activation pattern (CAP) analysis. The CAP method relies on few model assumptions and CAP-based measurements provide quantitative information of network temporal dynamics. One limitation of existing CAP-related methods is that the compu...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.01.019
更新日期：2018-05-15 00:00:00
abstract：:Automated measures of cerebral magnetic resonance images (MRI) often provide greater speed and reliability compared to manual techniques but can be particularly sensitive to motion artifact. This study employed an automatic MRI analysis program that quantified regional gray matter volume and created images for verific...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1006/nimg.2002.1076
更新日期：2002-05-01 00:00:00
abstract：:The purpose of this paper is to compare volume- and boundary-based morphometry methods by applying them in the statistical analysis of 2-D shapes. The methods discussed in the first category include voxel-, deformation-, and tensor-based morphometry. The active shape model is demonstrated as an example of the second c...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.12.068
更新日期：2009-04-15 00:00:00
abstract：:Apathy and depression are heterogeneous syndromes with symptoms that overlap clinically. This clinical overlap leads to problems with classification and diagnosis in clinical populations. No functional imaging study has attempted to separate brain regions altered in apathy from those altered in depression in a clinica...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.07.012
更新日期：2013-11-01 00:00:00
abstract：:Despite its importance as the prime method for non-invasive assessment of human brain function, functional MRI (fMRI) was repeatedly challenged with regards to the validity of the fMRI-derived brain activation maps. Amygdala fMRI was particularly targeted, as the amygdala's anatomical position in the ventral brain com...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.116585
更新日期：2020-05-01 00:00:00
abstract：:Event-related functional magnetic resonance imaging was used to assess healthy adults while they performed spatial and temporal context memory tasks matched in task structure. After equating task structure between spatial versus temporal context tasks, subjects reported using similar strategies across tasks and we obs...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.09.001
更新日期：2011-01-15 00:00:00
abstract：:The ability to regulate temptation and manage appetitive cravings is an important aspect of healthy adolescent development, but the neural systems underlying this process are understudied. In the present study, 60 healthy females evenly distributed from 10 to 23years of age used reappraisal to regulate the desire to c...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.12.037
更新日期：2015-03-01 00:00:00
abstract：:Mäkinen et al. [Mäkinen, V., Tiitinen, H., May, P., 2005. Auditory event-related responses are generated independently of ongoing brain activity. Neuroimage 24, 961-968] suggest the use of amplitude variance to distinguish the evoked response from phase reset. Because their data do not exhibit a drop in amplitude vari...
journal_title：NeuroImage
pub_type： 评论,杂志文章
doi：10.1016/j.neuroimage.2005.08.041
更新日期：2006-02-01 00:00:00
abstract：:Development of working memory (WM) aptitude parallels structural changes in the frontal-parietal association cortices important for performance within this cognitive domain. The cerebellum has been proposed to function in support of the postulated phonological loop component of verbal WM, and along with frontal and pa...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.05.057
更新日期：2008-10-01 00:00:00
abstract：:We proposed ICA-AROMA as a strategy for the removal of motion-related artifacts from fMRI data (Pruim et al., 2015). ICA-AROMA automatically identifies and subsequently removes data-driven derived components that represent motion-related artifacts. Here we present an extensive evaluation of ICA-AROMA by comparing our ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.02.063
更新日期：2015-05-15 00:00:00
