Dynamic changes in the cerebral metabolic rate of O2 and oxygen extraction ratio in event-related functional MRI.

Abstract:

:Dynamic changes in the cerebral metabolic rate of oxygen (CMRO(2)) and oxygen extraction ratio (OER) in an event-related functional MRI (ER-fMRI) were measured in this study. Six subjects participated in this study at a magnetic field of 1.9 T. Cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) changes were acquired during the brief visual stimulation, and the corresponding changes in CMRO(2) and OER were then determined. The results showed that the maximum relative changes in CMRO(2) and OER were about 10.36 +/- 0.85 and -6.54 +/- 0.55%, respectively, while the maximum changes in CBF and BOLD were approximately 17.35 +/- 1.37 and 1.03 +/- 0.06%, respectively. The CBF, CMRO(2), and OER changes reach their maximum approximately 1 s earlier than the BOLD signal change (4.15 +/- 0.21, 4.16 +/- 0.21, and 4.17 +/- 0.21 s vs 5.12 +/- 0.24 s after stimulation, P < 0.05).

journal_name

Neuroimage

journal_title

NeuroImage

authors

Feng CM,Liu HL,Fox PT,Gao JH

doi

10.1016/s1053-8119(02)00023-x

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

257-62

issue

2

eissn

1053-8119

issn

1095-9572

pii

S105381190200023X

journal_volume

18

pub_type

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