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Amyloid and tau PET demonstrate region-specific associations in normal older people.

Abstract：

:β-amyloid (Aβ) and tau pathology become increasingly prevalent with age, however, the spatial relationship between the two pathologies remains unknown. We examined local (same region) and non-local (different region) associations between these 2 aggregated proteins in 46 normal older adults using [18F]AV-1451 (for tau) and [11C]PiB (for Aβ) positron emission tomography (PET) and 1.5T magnetic resonance imaging (MRI) images. While local voxelwise analyses showed associations between PiB and AV-1451 tracer largely in the temporal lobes, k-means clustering revealed that some of these associations were driven by regions with low tracer retention. We followed this up with a whole-brain region-by-region (local and non-local) partial correlational analysis. We calculated each participant's mean AV-1451 and PiB uptake values within 87 regions of interest (ROI). Pairwise ROI analysis demonstrated many positive PiB-AV-1451 associations. Importantly, strong positive partial correlations (controlling for age, sex, and global gray matter fraction, p<.01) were identified between PiB in multiple regions of association cortex and AV-1451 in temporal cortical ROIs. There were also less frequent and weaker positive associations of regional PiB with frontoparietal AV-1451 uptake. Particularly in temporal lobe ROIs, AV-1451 uptake was strongly predicted by PiB across multiple ROI locations. These data indicate that Aβ and tau pathology show significant local and non-local regional associations among cognitively normal elderly, with increased PiB uptake throughout the cortex correlating with increased temporal lobe AV-1451 uptake. The spatial relationship between Aβ and tau accumulation does not appear to be specific to Aβ location, suggesting a regional vulnerability of temporal brain regions to tau accumulation regardless of where Aβ accumulates.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Lockhart SN,Schöll M,Baker SL,Ayakta N,Swinnerton KN,Bell RK,Mellinger TJ,Shah VD,O'Neil JP,Janabi M,Jagust WJ

doi

10.1016/j.neuroimage.2017.02.051

subject

Has Abstract

pub_date

2017-04-15 00:00:00

pages

191-199

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(17)30162-3

journal_volume

150

pub_type

杂志文章

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Amyloid and tau PET demonstrate region-specific associations in normal older people.