Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning.

Abstract:

:We used event-related fMRI to measure neural activity in volunteer subjects during acquisition of an implicit association between a visual conditioned stimulus (CS+) (angry face) and an auditory unconditioned stimulus (UCS) (aversive, loud noise). Three distinct functional regions were identified within left amygdala: a UCS (noise)-related lateral region, a CS+-related ventral region, and a dorsal region where CS+-related responses changed progressively across the learning session. Differential neural responses to the visual CS+ were also evoked in extrastriate and auditory cortices. Our results indicate that learning an association between biologically salient stimuli of different sensory modalities involves parallel changes of neural activity in segregated amygdala subregions and unimodal sensory cortices.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Morris JS,Buchel C,Dolan RJ

doi

10.1006/nimg.2000.0721

keywords:

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

1044-52

issue

6 Pt 1

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(00)90721-3

journal_volume

13

pub_type

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