Abstract：
:Estimating and modeling functional connectivity in the brain is a challenging problem with potential applications in the understanding of brain organization and various neurological and neuropsychological conditions. An important objective in connectivity analysis is to determine the connections between regions of interest in the brain. However, traditional functional connectivity analyses have frequently focused on modeling interactions between time series recordings at individual sensors, voxels, or vertices despite the fact that a single region of interest will often include multiple such recordings. In this paper, we present a novel measure of interaction between regions of interest rather than individual signals. The proposed measure, termed canonical Granger causality, combines ideas from canonical correlation and Granger causality analysis to yield a measure that reflects directed causality between two regions of interest. In particular, canonical Granger causality uses optimized linear combinations of signals from each region of interest to enable accurate causality measurements from substantially less data compared to alternative multivariate methods that have previously been proposed for this scenario. The optimized linear combinations are obtained using a variation of a technique developed for optimization on the Stiefel manifold. We demonstrate the advantages of canonical Granger causality in comparison to alternative causality measures for a range of different simulated datasets. We also apply the proposed measure to local field potential data recorded in a macaque brain during a visuomotor task. Results demonstrate that canonical Granger causality can be used to identify causal relationships between striate and prestriate cortexes in cases where standard Granger causality is unable to identify statistically significant interactions.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Ashrafulla S,Haldar JP,Joshi AA,Leahy RMdoi
10.1016/j.neuroimage.2013.06.056subject
Has Abstractpub_date
2013-12-01 00:00:00pages
189-99eissn
1053-8119issn
1095-9572pii
S1053-8119(13)00693-9journal_volume
83pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:White matter thalamo-cortical fibers allow the communication of distant brain regions by carrying neuronal signals. Mapping non-invasively the information flow within white matter fibers is regarded so far as impossible. We investigated here whether information flow propagating along thalamo-cortical fibers can be det...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.01.054
更新日期：2012-04-02 00:00:00
abstract：:Semantic priming occurs when a subject is faster in recognising a target word when it is preceded by a related word compared to an unrelated word. The effect is attributed to automatic or controlled processing mechanisms elicited by short or long interstimulus intervals (ISIs) between primes and targets. We employed e...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/s1053-8119(03)00279-9
更新日期：2003-09-01 00:00:00
abstract：:We used positron emission tomography (PET) to examine within-day learning of timed motor sequences. The results of this experiment are novel in showing an interaction between cerebellum and primary motor cortex (M1) during learning that appears to be mediated by the dentate nucleus (DN) and in demonstrating that activ...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.02.041
更新日期：2005-07-01 00:00:00
abstract：:We present a new shape-based approach for regional group activation analysis in fMRI studies. The method restricts anatomical normalization, spatial smoothing and random effects statistical analysis to the space inside and around a structure of interest. Normalization involves finding intersubject correspondences betw...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.01.029
更新日期：2007-05-01 00:00:00
abstract：:Diffusion MRI combined with biophysical modeling allows for the description of a white matter (WM) fiber bundle in terms of compartment specific white matter tract integrity (WMTI) metrics, which include intra-axonal diffusivity (Daxon), extra-axonal axial diffusivity (De||), extra-axonal radial diffusivity (De┴), axo...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.05.061
更新日期：2015-09-01 00:00:00
abstract：:This study examined neural responses in nine right-handed healthy individuals while they viewed mild and intense expressions of four emotions (fear, disgust, happiness, and sadness) contrasted with neutral faces in four event-related functional magnetic resonance imaging experiments. Orthogonal polynomial trend analys...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/s1053-8119(03)00085-5
更新日期：2003-08-01 00:00:00
abstract：:There has been recent interest in the neural correlates of visual short-term memory (VSTM) interference by irrelevant perceptual input. These studies, however, presented distracters that were subjected to conscious scrutiny by participants thus strongly involving attentional control mechanisms. In order to minimize th...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.07.062
更新日期：2012-01-02 00:00:00
abstract：:Characterization of neural and hemodynamic biomarkers of epileptic activity that can be measured using non-invasive techniques is fundamental to the accurate identification of the epileptogenic zone (EZ) in the clinical setting. Recently, oscillations at gamma-band frequencies and above (>30 Hz) have been suggested to...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.04.014
更新日期：2014-08-15 00:00:00
abstract：:When functional neuroimaging researchers draw conclusions about the sensory, cognitive, or motor processes that are associated with changes in brain activity, they are making assumptions about the component processes involved in performing a complex behavioral task. We demonstrate the danger in making such assumptions...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2003.10.011
更新日期：2004-03-01 00:00:00
abstract：:A long-standing core question in cognitive science is whether different modalities and representation types (pictures, words, sounds, etc.) access a common store of semantic information. Although different input types have been shown to activate a shared network of brain regions, this does not necessitate that there i...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.03.037
更新日期：2017-07-15 00:00:00
abstract：:Diffuse optical tomography is most accurate when an individual's MRI data can be used as a spatial prior for image reconstruction and for visualization of the resulting images of changes in oxy- and deoxy-hemoglobin concentration. As this necessitates an MRI scan to be performed for each study, which undermines many o...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.06.028
更新日期：2014-10-15 00:00:00
abstract：BACKGROUND:Once considered mere noise, fMRI-based functional connectivity has become a major neuroscience tool in part due to early studies demonstrating its reliability. These fundamental studies revealed only the tip of the iceberg; over the past decade, many test-retest reliability studies have continued to add nuan...
journal_title：NeuroImage
pub_type： 杂志文章,meta分析
doi：10.1016/j.neuroimage.2019.116157
更新日期：2019-12-01 00:00:00
abstract：:Advances in the literature of sex-related differences in autobiographical memory increasingly tend to highlight the importance of psychosocial factors such as gender identity, which may explain these differences better than sex as a biological factor. To date, however, none of these behavioral studies have investigate...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117507
更新日期：2021-01-15 00:00:00
abstract：:The key idea of statistical hypothesis testing is to fix, and thereby control, the Type I error (false positive) rate across samples of any size. Multiple comparisons inflate the global (family-wise) Type I error rate and the traditional solution to maintaining control of the error rate is to increase the local (compa...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.08.009
更新日期：2015-12-01 00:00:00
abstract：:High-resolution functional magnetic resonance imaging (hi-res fMRI) promises to help bridge the gap between the macro- and the microview of brain function afforded by conventional neuroimaging and invasive cell recording, respectively. Hi-res fMRI (voxel volume journal_title：NeuroImage pub_type： 杂志文章,评审 doi：10.1016/j.neuroimage.2007.02.022 更新日期：2007-12-01 00:00:00
abstract：:Neuropathological events featuring early stages of Alzheimer's disease (AD) appear in the entorhinal cortex (EC), subiculum (SB) and cornu ammonis 1 (CA1) of hippocampus, which may account for associative memory deficits in non-demented people with mild cognitive impairment (MCI). To test this hypothesis in vivo, we i...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.05.047
更新日期：2011-08-15 00:00:00
abstract：:Although anatomical constraints have been shown to be effective for MEG and EEG inverse solutions, there are still no effective physiological constraints. Strength of the current generator is normally described by the moment of an equivalent current dipole Q. This value is quite variable since it depends on size of ac...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.02.003
更新日期：2015-05-01 00:00:00
abstract：:Chemical exchange between water and labile protons from amino-acids, proteins and other molecules can be exploited to provide tissue contrast with magnetic resonance imaging (MRI) techniques. Using an off-resonance Spin-Locking (SL) scheme for signal preparation is advantageous because the image contrast can be tuned ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.08.014
更新日期：2012-01-16 00:00:00
abstract：:Our objective was to investigate correlations between clinical motor scores and cerebral sensorimotor activation to demonstrate that this reorganization is the neural substratum of motor recovery. Correlation analyses identified reorganization processes shared by all patients. Nine patients with first-time corticospin...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2003.08.017
更新日期：2003-12-01 00:00:00
abstract：:Salient stimuli are characterized by their capability to perturb and seize available cognitive resources. Although the striatum and its dopaminergic inputs respond to a variety of stimuli categorically defined as salient, including rewards, the relationship between striatal activity and saliency is not well understood...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.08.006
更新日期：2006-02-01 00:00:00
abstract：:Much of the variation in both neuronal and behavioral responses to stimuli can be explained by pre-stimulus fluctuations in brain activity. We hypothesized that also errors are the result of stochastic fluctuations in pre-stimulus activity and investigated the temporal dynamics of the scalp topography and their concom...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.10.033
更新日期：2010-02-01 00:00:00
abstract：:Notwithstanding the apparent demands regarding fine motor skills that are required to perform in action video games, the motor nervous system of players has not been studied systematically. In the present study, we hypothesized to find differences in sensorimotor performance and corticospinal characteristics between a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117576
更新日期：2021-02-01 00:00:00
abstract：:Developmental dyslexia has been associated with a dysfunction of a brain region in the left inferior occipitotemporal cortex, called the "visual word-form area" (VWFA). In adult normal readers, the VWFA is specialized for print processing and sensitive to the orthographic familiarity of letter strings. However, it is ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.05.021
更新日期：2009-10-01 00:00:00
abstract：:Perceptual similarity is a cognitive judgment that represents the end-stage of a complex cascade of hierarchical processing throughout visual cortex. Previous studies have shown a correspondence between the similarity of coarse-scale fMRI activation patterns and the perceived similarity of visual stimuli, suggesting t...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.02.019
更新日期：2016-05-15 00:00:00
abstract：:Q-ball imaging has the ability to discriminate multiple intravoxel fiber populations within regions of complex white matter architecture. This information can be used for fiber tracking; however, diffusion MR is susceptible to noise and multiple other sources of uncertainty affecting the measured orientation of fiber ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.08.021
更新日期：2008-01-01 00:00:00
abstract：:Processing of relational information is a prerequisite underlying a number of higher cognitive faculties. Different brain regions within the frontal cortex have been implicated in supporting this function. The present study aimed at differentiating the roles of two frontal areas - anterior prefrontal cortex (aPFC) and...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.09.009
更新日期：2010-02-01 00:00:00
abstract：:Cortical functional changes, with the potential to limit the functional consequences of tissue injury, have been shown in patients with multiple sclerosis (MS). In this study, we assessed the influence of MS-related tissue damage of the brain portion of the left pyramidal tract on the corresponding movement-associated...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2004.05.005
更新日期：2004-09-01 00:00:00
abstract：:The purpose of this paper is to compare volume- and boundary-based morphometry methods by applying them in the statistical analysis of 2-D shapes. The methods discussed in the first category include voxel-, deformation-, and tensor-based morphometry. The active shape model is demonstrated as an example of the second c...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.12.068
更新日期：2009-04-15 00:00:00
abstract：:Differences in the neural systems underlying visual search processes for young (n=17, mean age 19.6+/-1.9) and older (n=22, mean age 68.5+/-6) subjects were investigated combining the Event-Related Potential (ERP) technique with standardized Low-Resolution brain Electromagnetic Tomography (sLORETA) analyses. Behaviora...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.02.041
更新日期：2008-06-01 00:00:00
abstract：:Our empathetic abilities allow us to feel the pain of others. This phenomenon of vicarious feeling arises because the neural circuitry of feeling pain and seeing pain in others is shared. The neuropeptide oxytocin (OXT) is considered a robust facilitator of empathy, as intranasal OXT studies have repeatedly been shown...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.03.049
更新日期：2015-06-01 00:00:00
