Abstract:
:When functional neuroimaging researchers draw conclusions about the sensory, cognitive, or motor processes that are associated with changes in brain activity, they are making assumptions about the component processes involved in performing a complex behavioral task. We demonstrate the danger in making such assumptions using, as an example, the n-back task, which has been widely used in neuroimaging studies of working memory. Neuroimaging researchers have assumed that the letter n-back task only engages processes involved in the short-term maintenance and manipulation of verbal information. We report three behavioral experiments demonstrating that the letter n-back task additionally recruits spatial processes. A fourth experiment suggested that the location n-back task may recruit verbal processes in addition to spatial processes. These results call into question conclusions that have been drawn about the neural basis of working memory. More broadly, our results demonstrate that task analysis is a vital partner of neuroimaging in the cognitive neuroscience enterprise.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Meegan DV,Purc-Stephenson R,Honsberger MJ,Topan Mdoi
10.1016/j.neuroimage.2003.10.011keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
1026-36issue
3eissn
1053-8119issn
1095-9572pii
S105381190300661Xjournal_volume
21pub_type
临床试验,杂志文章相关文献
NEUROIMAGE文献大全abstract::Reward and punishment shape behavior, but the mechanisms underlying their effect on skill learning are not well understood. Here, we tested whether the functional connectivity of premotor cortex (PMC), a region known to be critical for learning of sequencing skills, is altered after training when reward or punishment ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.01.009
更新日期:2019-04-01 00:00:00
abstract::Owing to its intrinsic characteristics, spatiotemporally encoded (SPEN) imaging is less sensitive to adverse effects due to field inhomogeneity in comparison with echo planar imaging, a feature highly desired for functional, diffusion, and real-time MRI. However, the quality of images obtained with SPEN MRI is still d...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.10.041
更新日期:2015-01-15 00:00:00
abstract::Connectome-based predictive modeling (CPM; Finn et al., 2015; Shen et al., 2017) was recently developed to predict individual differences in traits and behaviors, including fluid intelligence (Finn et al., 2015) and sustained attention (Rosenberg et al., 2016a), from functional brain connectivity (FC) measured with fM...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.11.010
更新日期:2018-02-15 00:00:00
abstract::Sleep deprivation decreases an individual's cognitive function. When cognitive impairment reaches a certain level, human errors occur and may even result in accidents. Previous research has shown that sensory gating is a basic mechanism in cognitive function, but only limited studies have so far reported how it is aff...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.04.057
更新日期:2019-08-15 00:00:00
abstract::We investigated neural correlates of retrieval success for music memory using event-related functional magnetic resonance imaging. To minimize the interference from MRI scan noise, we used sparse temporal sampling technique. Newly composed music materials were employed as stimuli, which enabled us to detect regions in...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.08.024
更新日期:2008-01-01 00:00:00
abstract::Primary somatosensory cortex (SI) and posterior parietal cortex (PPC) are activated by noxious stimulation. In neurophysiological studies using magnetoencephalography (MEG), however, it has been difficult to separate the activity in SI from that in PPC following stimulation of the upper limb, since the hand area of SI...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.05.017
更新日期:2008-08-15 00:00:00
abstract::Effort expenditure has an aversive connotation and it can lower hedonic feelings. In this study, we explored the electrophysiological correlates of the complex interplay of reward processing with cost anticipation. To this aim, healthy adult participants performed a gambling task where the outcome (monetary reward vs....
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.02.049
更新日期:2018-06-01 00:00:00
abstract::The advantages of high-resolution diffusion tensor imaging (DTI) have been demonstrated in a recent post-mortem human brain study (Miller et al., NeuroImage 2011;57(1):167-181), showing that white matter fiber tracts can be much more accurately detected in data at a submillimeter isotropic resolution. To our knowledge...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.06.016
更新日期:2015-09-01 00:00:00
abstract::To elucidate the function of the lateral prefrontal cortex (LPFC) in taste encoding, it is worth applying to taste, the psychological paradigms of intentional memorization that have been used with other extensively studied senses, and thus updating current models for LPFC functions to include a taste modality. Using m...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.12.021
更新日期:2006-06-01 00:00:00
abstract::Proton magnetic resonance spectroscopy (1H-MRS) has provided valuable information about the neurochemical profile of Alzheimer's disease (AD). However, its clinical utility has been limited in part by the lack of consistent information on how metabolite concentrations vary in the normal aging brain and in carriers of ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.03.031
更新日期:2017-05-15 00:00:00
abstract::This project aims to characterize the impact of underlying noise distributions on diffusion-weighted imaging. The noise floor is a well-known problem for traditional magnitude-based diffusion-weighted MRI (dMRI) data, leading to biased diffusion model fits and inaccurate signal averaging. Here, we introduce a total-va...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.07.074
更新日期:2015-11-15 00:00:00
abstract::The notion that the brain is organized into two complementary networks, one that is task-positive and supports externally-oriented processing, and the other that is task-negative and supports internally-oriented processing, has recently attracted increasing attention. The goal of the present study was to investigate i...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.07.058
更新日期:2010-01-01 00:00:00
abstract::Breathing rate and depth influence the concentration of carbon dioxide in the blood, altering cerebral blood flow and thus functional magnetic resonance imaging (fMRI) signals. Such respiratory fluctuations can have substantial influence in studies of fMRI signal covariance in subjects at rest, the so-called "resting ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116234
更新日期:2020-01-01 00:00:00
abstract::This study examined the sensitivity of ultra-high field (16.4 T) diffusion tensor imaging (DTI; 70 μm in-plane resolution, 1mm slice thickness) to evaluate the spatiotemporal development of severe mid-thoracic contusive spinal cord injury (SCI) in mice. In vivo imaging was performed prior to SCI, then again at 2h, 1 d...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.06.019
更新日期:2013-11-15 00:00:00
abstract:INTRODUCTION:[(11)C]Cimbi-36 is a recently developed serotonin 2A (5-HT2A) receptor agonist positron emission tomography (PET) radioligand that has been successfully applied for human neuroimaging. Here, we investigate the test-retest variability of cerebral [(11)C]Cimbi-36 PET and compare [(11)C]Cimbi-36 and the 5-HT2...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.02.001
更新日期:2016-04-15 00:00:00
abstract::Magnetoencephalography was used to investigate the relationship between the sustained magnetic field in auditory cortex and the perception of periodic sounds. The response to regular and irregular click trains was measured at three sound intensities. Two separate sources were isolated adjacent to primary auditory cort...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2001.0949
更新日期:2002-01-01 00:00:00
abstract::Accurate processing of nonvisual stimuli is fundamental to humans with visual impairments. In this population, moving sounds activate an occipito-temporal region thought to encompass the equivalent of monkey area MT+, but it remains unclear whether the signal carries information beyond the mere presence of motion. To ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.04.266
更新日期:2011-05-15 00:00:00
abstract::High-resolution diffusion MRI can provide the ability to resolve small brain structures, enabling investigations of detailed white matter architecture. A major challenge for in vivo high-resolution diffusion MRI is the low signal-to-noise ratio. In this work, we combine two highly compatible methods, ultra-high field ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.08.054
更新日期:2016-12-01 00:00:00
abstract::We report on the initial imaging findings with a new technique for the simultaneous and continuous acquisition of functional MRI data and EEG recording. Thirty-seven stereotyped interictal epileptiform discharges (spikes) were identified on EEG recorded continuously during the fMRI acquisition on a patient with epilep...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2001.0853
更新日期:2001-09-01 00:00:00
abstract::Though the hippocampus has been associated with encoding and retrieval processes in episodic memory, the precise nature of its involvement in working memory has yet to be determined. This functional magnetic resonance imaging (fMRI) study employed a verbal working memory paradigm that allows for the within-subject com...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2005.01.038
更新日期:2005-05-01 00:00:00
abstract::Cerebral blood volume (CBV)-weighted endogenous functional contrast can be obtained by the vascular space occupancy (VASO) technique. VASO relies on nonselective inversion for nulling blood signals, but the implementation of VASO at magnetic fields higher than 3 T is difficult due to converging T(1) values of tissue a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.11.045
更新日期:2008-03-01 00:00:00
abstract::We determined if high-frequency gamma-oscillations (50- to 150-Hz) were induced by simple auditory communication over the language network areas in children with focal epilepsy. Four children (aged 7, 9, 10 and 16 years) with intractable left-hemispheric focal epilepsy underwent extraoperative electrocorticography (EC...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.03.011
更新日期:2008-07-01 00:00:00
abstract::Results of this PET-O15 water activation study confirm the implication of supplementary motor areas during time estimation tasks. They also show that the cortical-subcortical network associated with temporal processing is impaired in schizophrenia. Following recent proposals of time dynamic networks, this impairment m...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.09.010
更新日期:2005-01-15 00:00:00
abstract::It is well established that it is possible to observe spontaneous, highly structured, fluctuations in human brain activity from functional magnetic resonance imaging (fMRI) when the subject is 'at rest'. However, characterising this activity in an interpretable manner is still a very open problem. In this paper, we in...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.01.013
更新日期:2015-04-01 00:00:00
abstract::The publisher regrets due to an error in the publishing process the above articles was accidentally withdrawn and has now been published in (Neuroimage 83C December 2013 https://doi.org/10.1016/j.neuroimage.2013.05.115). The publisher would like to apologize for any inconvenience caused. ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.02.041
更新日期:2013-07-15 00:00:00
abstract::Neuroimaging studies have identified regional brain dysfunctions in schizophrenia, but their dynamic consequences remain unclear. This study reports electrophysiological evaluation of medicated schizophrenic patients during performance of the Wisconsin Card Sorting Test. Using event-related potentials (ERPs), averaged...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/s1053-8119(03)00240-4
更新日期:2003-08-01 00:00:00
abstract::Recently, we showed that the functional heterogeneity of the right dorsal premotor (PMd) cortex could be better understood by dividing it into five subregions that showed different behavioral associations according to task-based activations studies. The present study investigated whether the revealed behavioral profil...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.05.053
更新日期:2017-08-15 00:00:00
abstract::The relationship between anatomic and resting state functional connectivity of large-scale brain networks is a major focus of current research. In previous work, we introduced a model based on eigen decomposition of the Laplacian which predicts the functional network from the structural network in healthy brains. In t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117705
更新日期:2020-12-30 00:00:00
abstract::The human infant is particularly immature at birth and brain maturation, with the myelination of white matter fibers, is protracted until adulthood. Diffusion tensor imaging offers the possibility to describe non invasively the fascicles spatial organization at an early stage and to follow the cerebral maturation with...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.11.022
更新日期:2006-05-01 00:00:00
abstract::The cerebellum is thought to be engaged not only in motor control, but also in the neural network dedicated to visual processing of body motion. However, the pattern of connectivity within this network, in particular, between the cortical circuitry for observation of others' actions and the cerebellum remains largely ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.08.039
更新日期:2012-02-01 00:00:00