Abstract:
:Recently, we showed that the functional heterogeneity of the right dorsal premotor (PMd) cortex could be better understood by dividing it into five subregions that showed different behavioral associations according to task-based activations studies. The present study investigated whether the revealed behavioral profile could be corroborated and complemented by a structural brain behavior correlation approach in two healthy adults cohorts. Grey matter volume within the five volumes of interest (VOI-GM) was computed using voxel-based morphometry. Associations between the inter-individual differences in VOI-GM and performance across a range of neuropsychological tests were assessed in the two cohorts with and without correction for demographical variables. Additional analyses were performed in random smaller subsamples drawn from each of the two cohorts. In both cohorts, correlation coefficients were low; only few were significant and a considerable number of correlations were counterintuitive in their directions (i.e., higher performance related to lower grey matter volume). Furthermore, correlation patterns were inconsistent between the two cohorts. Subsampling revealed that correlation patterns could vary widely across small samples and that negative correlations were as likely as positive correlations. Thus, the structural brain-behavior approach did not corroborate the functional profiles of the PMd subregions inferred from activation studies, suggesting that local recruitment by fMRI studies does not necessarily imply covariance of local structure with behavioral performance in healthy adults. We discuss the limitations of such studies and related recommendations for future studies.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Genon S,Wensing T,Reid A,Hoffstaedter F,Caspers S,Grefkes C,Nickl-Jockschat T,Eickhoff SBdoi
10.1016/j.neuroimage.2017.05.053subject
Has Abstractpub_date
2017-08-15 00:00:00pages
144-156eissn
1053-8119issn
1095-9572pii
S1053-8119(17)30452-4journal_volume
157pub_type
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