Abstract：
:The relationship between anatomic and resting state functional connectivity of large-scale brain networks is a major focus of current research. In previous work, we introduced a model based on eigen decomposition of the Laplacian which predicts the functional network from the structural network in healthy brains. In this work, we apply the eigen decomposition model to two types of epilepsy; temporal lobe epilepsy associated with mesial temporal sclerosis, and MRI-normal temporal lobe epilepsy. Our findings show that the eigen relationship between function and structure holds for patients with temporal lobe epilepsy as well as normal individuals. These results suggest that the brain under TLE conditions reconfigures and rewires the fine-scale connectivity (a process which the model parameters are putatively sensitive to), in order to achieve the necessary structure-function relationship.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Abdelnour F,Dayan M,Devinsky O,Thesen T,Raj Adoi
10.1016/j.neuroimage.2020.117705subject
Has Abstractpub_date
2020-12-30 00:00:00pages
117705eissn
1053-8119issn
1095-9572pii
S1053-8119(20)31190-3journal_volume
228pub_type
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