Abstract:
:In this work, we propose to use fiber tracking in order to analyze and quantify the state of the pyramidal tracts in patients affected by tumors. We introduce a framework that includes an automatic method to obtain the fibers involved in the pyramidal tract of any subject, in order to compare robustly fiber bundles affected by tumors with healthy fiber tracts from control subjects and also to quantify the relative state of degeneration between the fiber tracts in the two hemispheres of the same patient. The comparative analyses proposed in our methodology are based on a new set of measures on the pyramidal tract, which take into account intrinsic properties of the fibers involved in the bundle as well as the similarity with the pyramidal tract of a standard healthy subject, modeled as the average of a set of controls. In order to perform better comparison studies and to take into account more information of the whole bundle, a mapping technique is used to represent the fiber tracts in 2D. Here, we show a set of experiments using 5 tumor patients and 10 control subjects, including pre- and post-operative studies in patients that have been treated with partial or total tumor resection. The results obtained indicate the usefulness of the method showing good overall performance. A reproducibility study using several acquisitions of the same patient is also presented to validate the techniques employed.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Cárdenes R,Muñoz-Moreno E,Sarabia-Herrero R,Rodríguez-Velasco M,Fuertes-Alija JJ,Martin-Fernandez Mdoi
10.1016/j.neuroimage.2009.12.032subject
Has Abstractpub_date
2010-03-01 00:00:00pages
27-39issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(09)01321-4journal_volume
50pub_type
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