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A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability.

Abstract：

:There is a high need to develop quantitative imaging methods capable of providing detailed brain localization information of several molecular species simultaneously. In addition, extensive information on the effect of the blood-brain barrier on the penetration, distribution and efficacy of neuroactive compounds is required. Thus, we have developed a mass spectrometry imaging method to visualize and quantify the brain distribution of drugs with varying blood-brain barrier permeability. With this approach, we were able to determine blood-brain barrier transport of different drugs and define the drug distribution in very small brain structures (e.g., choroid plexus) due to the high spatial resolution provided. Simultaneously, we investigated the effect of drug-drug interactions by inhibiting the membrane transporter multidrug resistance 1 protein. We propose that the described approach can serve as a valuable analytical tool during the development of neuroactive drugs, as it can provide physiologically relevant information often neglected by traditional imaging technologies.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Vallianatou T,Strittmatter N,Nilsson A,Shariatgorji M,Hamm G,Pereira M,Källback P,Svenningsson P,Karlgren M,Goodwin RJA,Andrén PE

doi

10.1016/j.neuroimage.2018.01.013

subject

Has Abstract

pub_date

2018-05-15 00:00:00

pages

808-816

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(18)30015-6

journal_volume

172

pub_type

杂志文章

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