当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T.

Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T.

Abstract：

:T1 mapping lacks specificity toward a single particular biological feature, however it has the potential to discriminate spinal cord regional tissue organization and characterize tissue microstructural impairments occurring in neurodegenerative pathologies. In this exploratory work, T1 mapping of the cervical spinal cord with a 300-μm in-plane resolution was performed on fourteen healthy subjects at 7T, using the MP2RAGE sequence. Individual images from C1 to C7 vertebral levels provided a clear delineation of spinal cord anatomical details and substructures including motor columns within gray matter (GM) horns, anterior median fissure, central canal, ventral, lateral and dorsal white matter (WM) fasciculi, and posterior median septum. Group studies highlighted regional T1 differences between regions of interest so far hardly visible at lower spatial resolution. Two-dimensional averaged T1 maps and manual parcellation of GM and WM substructures were built based on these data. Benefiting from the very high spatial resolution achievable at ultra-high field for T1 mapping, this work contributes to improve the in vivo characterization of the cervical spinal cord. By allowing investigation within a wider range of functional regions, it also opens new perspectives for pathology diagnosis such as motor neuron disease, neuropathic pain or refined investigation of neurodegeneration.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Massire A,Rasoanandrianina H,Guye M,Callot V

doi

10.1016/j.neuroimage.2019.116275

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

116275

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(19)30866-3

journal_volume

205

pub_type

杂志文章

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