Real-time fMRI and its application to neurofeedback.

Abstract:

:Real-time fMRI (rtfMRI) allows immediate access to experimental results by analyzing data as fast as they are acquired. It was devised soon after the inception of fMRI and has undergone a rapid development since then. The availability of results during the ongoing experiment facilitates a variety of applications such as quality assurance or fast functional localization. RtfMRI can also be used as a brain-computer interface (BCI) with high spatial resolution and whole-brain coverage, overcoming limitations of EEG based BCIs. This review will focus on the application of rtfMRI BCIs to neurofeedback, i.e., the online feedback of the blood oxygen level dependent (BOLD) response. I will motivate its development and place its beginnings into the contemporary scientific context by providing an account of our early work at the University of Tübingen, followed by a review of the accomplishments and the current state of rtfMRI neurofeedback. RtfMRI neurofeedback has been used to train self-regulation of the local BOLD response in various different brain areas and to study consequential behavioral effects. Behavioral effects such as modulation of pain, reaction time, linguistic or emotional processing have been shown in healthy and/or patient populations. RtfMRI neurofeedback presents a new paradigm for studying the relation between brain behavior and physiology, because the latter can be regarded as the independent variable (unlike in conventional neuroimaging studies where behavior is the independent variable). The initial results in patient populations improving pain, tinnitus, depression or modulating perception in schizophrenia are encouraging and merit further controlled clinical studies.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Weiskopf N

doi

10.1016/j.neuroimage.2011.10.009

subject

Has Abstract

pub_date

2012-08-15 00:00:00

pages

682-92

issue

2

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(11)01170-0

journal_volume

62

pub_type

历史文章,杂志文章,评审
  • Functional MRI of the human amygdala?

    abstract::In view of an increasing number of publications that deal with functional mapping of the human amygdala using blood oxygenation-level-dependent (BOLD) magnetic resonance imaging, we reevaluated the underlying image quality of T2*-weighted echoplanar imaging (EPI) and fast low angle shot (FLASH) sequences at 2.0-T with...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1006/nimg.2001.0802

    authors: Merboldt KD,Fransson P,Bruhn H,Frahm J

    更新日期:2001-08-01 00:00:00

  • Hippocampus-specific fMRI group activation analysis using the continuous medial representation.

    abstract::We present a new shape-based approach for regional group activation analysis in fMRI studies. The method restricts anatomical normalization, spatial smoothing and random effects statistical analysis to the space inside and around a structure of interest. Normalization involves finding intersubject correspondences betw...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2007.01.029

    authors: Yushkevich PA,Detre JA,Mechanic-Hamilton D,Fernández-Seara MA,Tang KZ,Hoang A,Korczykowski M,Zhang H,Gee JC

    更新日期:2007-05-01 00:00:00

  • Individual differences in rCBF correlates of syntactic processing in sentence comprehension: effects of working memory and speed of processing.

    abstract::Positron emission tomography (PET) was used to determine the effect of working memory and speed of sentence processing on regional cerebral blood flow (rCBF) during syntactic processing in sentence comprehension. PET activity associated with making plausibility judgments about syntactically more complex subject-object...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/s1053-8119(03)00007-7

    authors: Waters G,Caplan D,Alpert N,Stanczak L

    更新日期:2003-05-01 00:00:00

  • Regional variation, hemispheric asymmetries and gender differences in pericortical white matter.

    abstract::Brain white matter tissue composition can be quantified using Diffusion Tensor Imaging (DTI) and Magnetization Transfer Imaging (MTI). Fractional Anisotropy (FA), derived from DTI, indexes the integrity, density and organization of axons. Magnetization Transfer Ratio (MTR), derived from MTI, indexes to the presence of...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2011.03.016

    authors: Kang X,Herron TJ,Woods DL

    更新日期:2011-06-15 00:00:00

  • Microglial Activation in the Right Amygdala-Entorhinal-Hippocampal Complex is Associated with Preserved Spatial Learning in AppNL-G-F mice.

    abstract:BACKGROUND:In Alzheimer`s disease (AD), regional heterogeneity of β-amyloid burden and microglial activation of individual patients is a well-known phenomenon. Recently, we described a high incidence of inter-individual regional heterogeneity in terms of asymmetry of plaque burden and microglial activation in β-amyloid...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2020.117707

    authors: Biechele G,Wind K,Blume T,Sacher C,Beyer L,Eckenweber F,Franzmeier N,Ewers M,Zott B,Lindner S,Gildehaus FJ,von Ungern-Sternberg B,Tahirovic S,Willem M,Bartenstein P,Cumming P,Rominger A,Herms J,Brendel M

    更新日期:2020-12-29 00:00:00

  • Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging.

    abstract::A key objective in neuroscience is to improve our understanding of the relationship between brain function and structure. We investigated this in the posterior visual pathways of healthy volunteers by applying functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) with tractography. The optic ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2003.11.022

    authors: Toosy AT,Ciccarelli O,Parker GJ,Wheeler-Kingshott CA,Miller DH,Thompson AJ

    更新日期:2004-04-01 00:00:00

  • Sustained magnetic fields reveal separate sites for sound level and temporal regularity in human auditory cortex.

    abstract::Magnetoencephalography was used to investigate the relationship between the sustained magnetic field in auditory cortex and the perception of periodic sounds. The response to regular and irregular click trains was measured at three sound intensities. Two separate sources were isolated adjacent to primary auditory cort...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1006/nimg.2001.0949

    authors: Gutschalk A,Patterson RD,Rupp A,Uppenkamp S,Scherg M

    更新日期:2002-01-01 00:00:00

  • Early detection of the chemical changes occurring during the induction and prevention of autoimmune-mediated demyelination detected by FT-IR imaging.

    abstract::Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Despite progress in understanding immunogenetic aspects of this disease, the mechanisms involved in lesion formation are unknown. To gain new insights into the neuropathology of MS, we used an i...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2009.09.053

    authors: Heraud P,Caine S,Campanale N,Karnezis T,McNaughton D,Wood BR,Tobin MJ,Bernard CC

    更新日期:2010-01-15 00:00:00

  • Functional basis of memory impairment in multiple sclerosis: a[18F]FDG PET study.

    abstract::Structural neuroimaging has been used to correlate lesional patterns with the cognitive profile of patients with multiple sclerosis (MS), especially for "frontal" dysfunction. However, a clear-cut anatomical explanation has yet to be found for the long-term memory deficit which is a hallmark of MS cognitive impairment...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1006/nimg.1996.0032

    authors: Paulesu E,Perani D,Fazio F,Comi G,Pozzilli C,Martinelli V,Filippi M,Bettinardi V,Sirabian G,Passafiume D,Anzini A,Lenzi GL,Canal N,Fieschi C

    更新日期:1996-10-01 00:00:00

  • Language in context: emergent features of word, sentence, and narrative comprehension.

    abstract::Context exerts a powerful effect on cognitive performance and is clearly important for language processing, where lexical, sentential, and narrative contexts should differentially engage neural systems that support lexical, compositional, and discourse level semantics. Equally important, but thus far unexplored, is th...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2004.12.013

    authors: Xu J,Kemeny S,Park G,Frattali C,Braun A

    更新日期:2005-04-15 00:00:00

  • A mini-cap for simultaneous EEG and fMRI recording in rodents.

    abstract::Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is now widely accepted as a prevailing tool to study brain functions. For over a decade, EEG caps with high-dense arrays of electrodes for EEG-fMRI studies in humans have been commercially available. However, simult...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.09.056

    authors: Sumiyoshi A,Riera JJ,Ogawa T,Kawashima R

    更新日期:2011-02-01 00:00:00

  • Integrating functional near-infrared spectroscopy in the characterization, assessment, and monitoring of cancer and treatment-related neurocognitive dysfunction.

    abstract::Cancer and cancer treatment-related neurocognitive dysfunction (CRND) (e.g., impairments in key cognitive domains of attention, memory, processing speed, and executive function), commonly referred to as "chemobrain" or "chemo-fog", can negatively impact patients' psychosocial functioning and quality of life. CRND is a...

    journal_title:NeuroImage

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroimage.2013.06.075

    authors: Jean-Pierre P

    更新日期:2014-01-15 00:00:00

  • Evidence for a general face salience signal in human amygdala.

    abstract::In the social neuroscience of face processing, multiple roles are attributed to amygdala: signalling of fear/threat-stimuli, of emotional expression, and general salience. The current study aimed at a direct comparison of amygdala activation attributable to these conditions by contrasting amygdala responses to matched...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.11.024

    authors: Santos A,Mier D,Kirsch P,Meyer-Lindenberg A

    更新日期:2011-02-14 00:00:00

  • A note on the phase locking value and its properties.

    abstract::We investigate the properties of the Phase Locking Value (PLV) and the Phase Lag Index (PLI) as metrics for quantifying interactions in bivariate local field potential (LFP), electroencephalography (EEG) and magnetoencephalography (MEG) data. In particular we describe the relationship between nonparametric estimates o...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2013.02.008

    authors: Aydore S,Pantazis D,Leahy RM

    更新日期:2013-07-01 00:00:00

  • 3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis.

    abstract::MRI at 3 T has increased sensitivity in detecting overt multiple sclerosis (MS) brain lesions; a growing body of data suggests clinically relevant damage occurs in the normal-appearing white matter (NAWM). We tested a novel pulse sequence to determine whether 3 T MRI spin-spin relaxometry detected damage in NAWM of MS...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2009.03.001

    authors: Neema M,Goldberg-Zimring D,Guss ZD,Healy BC,Guttmann CR,Houtchens MK,Weiner HL,Horsfield MA,Hackney DB,Alsop DC,Bakshi R

    更新日期:2009-07-01 00:00:00

  • Cortical dynamics during preparation and execution of reactive balance responses with distinct postural demands.

    abstract::The contributions of the cerebral cortex to human balance control are clearly demonstrated by the profound impact of cortical lesions on the ability to maintain standing balance. The cerebral cortex is thought to regulate subcortical postural centers to maintain upright balance and posture under varying environmental ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2018.12.045

    authors: Solis-Escalante T,van der Cruijsen J,de Kam D,van Kordelaar J,Weerdesteyn V,Schouten AC

    更新日期:2019-03-01 00:00:00

  • Effective connectivity during working memory and resting states: A DCM study.

    abstract::Although the relationship between resting-state functional connectivity and task-related activity has been addressed, the relationship between task and resting-state directed or effective connectivity - and its behavioral concomitants - remains elusive. We evaluated effective connectivity under an N-back working memor...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2017.12.067

    authors: Jung K,Friston KJ,Pae C,Choi HH,Tak S,Choi YK,Park B,Park CA,Cheong C,Park HJ

    更新日期:2018-04-01 00:00:00

  • Simultaneous control of error rates in fMRI data analysis.

    abstract::The key idea of statistical hypothesis testing is to fix, and thereby control, the Type I error (false positive) rate across samples of any size. Multiple comparisons inflate the global (family-wise) Type I error rate and the traditional solution to maintaining control of the error rate is to increase the local (compa...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2015.08.009

    authors: Kang H,Blume J,Ombao H,Badre D

    更新日期:2015-12-01 00:00:00

  • 'Whose atlas I use, his song I sing?' - The impact of anatomical atlases on fiber tract contributions to cognitive deficits after stroke.

    abstract::Nowadays, different anatomical atlases exist for the anatomical interpretation of the results from neuroimaging and lesion analysis studies that investigate the contribution of white matter fiber tract integrity to cognitive (dys)function. A major problem with the use of different atlases in different studies, however...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2017.09.051

    authors: de Haan B,Karnath HO

    更新日期:2017-12-01 00:00:00

  • A comparative analysis of mouse and human medial geniculate nucleus connectivity: a DTI and anterograde tracing study.

    abstract::Understanding the function and connectivity of thalamic nuclei is critical for understanding normal and pathological brain function. The medial geniculate nucleus (MGN) has been studied mostly in the context of auditory processing and its connection to the auditory cortex. However, there is a growing body of evidence ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2014.10.047

    authors: Keifer OP Jr,Gutman DA,Hecht EE,Keilholz SD,Ressler KJ

    更新日期:2015-01-15 00:00:00

  • Parietal cortex tracks the amount of information retrieved even when it is not the basis of a memory decision.

    abstract::Although the parietal cortex is not conventionally associated with memory, a large number of recent fMRI studies have suggested that that the parietal cortex may play a role in recognition memory. Activity in the lateral parietal cortex is correlated with the subjective impression that an item is old. It has therefore...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.11.066

    authors: Guerin SA,Miller MB

    更新日期:2011-03-15 00:00:00

  • Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals.

    abstract::Experience-dependent modulation of the visual evoked potential (VEP) is a promising proxy measure of synaptic plasticity in the cerebral cortex. However, existing studies are limited by small to moderate sample sizes as well as by considerable variability in how VEP modulation is quantified. In the present study, we u...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2020.117302

    authors: Valstad M,Moberget T,Roelfs D,Slapø NB,Timpe CMF,Beck D,Richard G,Sæther LS,Haatveit B,Skaug KA,Nordvik JE,Hatlestad-Hall C,Einevoll GT,Mäki-Marttunen T,Westlye LT,Jönsson EG,Andreassen OA,Elvsåshagen T

    更新日期:2020-12-01 00:00:00

  • Modelling the perceptual similarity of facial expressions from image statistics and neural responses.

    abstract::The ability to perceive facial expressions of emotion is essential for effective social communication. We investigated how the perception of facial expression emerges from the image properties that convey this important social signal, and how neural responses in face-selective brain regions might track these propertie...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2016.01.041

    authors: Sormaz M,Watson DM,Smith WAP,Young AW,Andrews TJ

    更新日期:2016-04-01 00:00:00

  • Surface rendering-based virtual intraventricular endoscopy: retrospective feasibility study and comparison to volume rendering-based approach.

    abstract:OBJECTIVE:Virtual endoscopic simulations using volume rendering (VR) have been proposed as a tool for training and understanding intraventricular anatomy. It is not known whether surface rendering (SR), an alternative to VR, can visualize intraventricular and subependymal structures better and thus making the virtual e...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2007.04.023

    authors: Nakajima N,Wada J,Miki T,Haraoka J,Hata N

    更新日期:2007-01-01 00:00:00

  • fMRI of pain processing in the brain: a within-animal comparative study of BOLD vs. CBV and noxious electrical vs. noxious mechanical stimulation in rat.

    abstract::This study aims to identify fMRI signatures of nociceptive processing in whole brain of anesthetized rats during noxious electrical stimulation (NES) and noxious mechanical stimulation (NMS) of paw. Activation patterns for NES were mapped with blood oxygen level dependent (BOLD) and cerebral blood volume (CBV) fMRI, r...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2011.08.002

    authors: Zhao F,Welsh D,Williams M,Coimbra A,Urban MO,Hargreaves R,Evelhoch J,Williams DS

    更新日期:2012-01-16 00:00:00

  • The MNI data-sharing and processing ecosystem.

    abstract::Neuroimaging has been facing a data deluge characterized by the exponential growth of both raw and processed data. As a result, mining the massive quantities of digital data collected in these studies offers unprecedented opportunities and has become paramount for today's research. As the neuroimaging community enters...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2015.08.076

    authors: Das S,Glatard T,MacIntyre LC,Madjar C,Rogers C,Rousseau ME,Rioux P,MacFarlane D,Mohades Z,Gnanasekaran R,Makowski C,Kostopoulos P,Adalat R,Khalili-Mahani N,Niso G,Moreau JT,Evans AC

    更新日期:2016-01-01 00:00:00

  • Effects of physiological noise in population analysis of diffusion tensor MRI data.

    abstract::The goal of this study is to characterize the potential effect of artifacts originating from physiological noise on statistical analysis of diffusion tensor MRI (DTI) data in a population. DTI derived quantities including mean diffusivity (Trace(D)), fractional anisotropy (FA), and principal eigenvector (ε(1)) are com...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.08.048

    authors: Walker L,Chang LC,Koay CG,Sharma N,Cohen L,Verma R,Pierpaoli C

    更新日期:2011-01-15 00:00:00

  • Individuals with schizophrenia present hypo- and hyperactivation during implicit cueing in an inhibitory task.

    abstract:BACKGROUND:The primary purpose of this investigation was to assess the neural correlates of implicit cueing during an inhibitory task in schizophrenia when performance accuracy was matched with healthy comparison subjects. METHODS:We compared 17 individuals with chronic schizophrenia (SZ; medicated, 13.9 average years...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2006.04.189

    authors: Arce E,Leland DS,Miller DA,Simmons AN,Winternheimer KC,Paulus MP

    更新日期:2006-08-15 00:00:00

  • A parcellation scheme based on von Mises-Fisher distributions and Markov random fields for segmenting brain regions using resting-state fMRI.

    abstract::Understanding the organization of the human brain requires identification of its functional subdivisions. Clustering schemes based on resting-state functional magnetic resonance imaging (fMRI) data are rapidly emerging as non-invasive alternatives to cytoarchitectonic mapping in postmortem brains. Here, we propose a n...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2012.09.067

    authors: Ryali S,Chen T,Supekar K,Menon V

    更新日期:2013-01-15 00:00:00

  • Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRO2.

    abstract::Functional magnetic resonance imaging (fMRI) using the blood oxygenation level-dependent (BOLD) contrast indirectly probes neuronal activity changes via evoked cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral metabolic rate of oxygen (CMRO2) changes. The gradient-echo BOLD signal is mostly sensitive...

    journal_title:NeuroImage

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroimage.2017.07.041

    authors: Huber L,Uludağ K,Möller HE

    更新日期:2019-08-15 00:00:00