Abstract：
:Brain white matter tissue composition can be quantified using Diffusion Tensor Imaging (DTI) and Magnetization Transfer Imaging (MTI). Fractional Anisotropy (FA), derived from DTI, indexes the integrity, density and organization of axons. Magnetization Transfer Ratio (MTR), derived from MTI, indexes to the presence of cell membranes and myelin. The combined use of FA and MTR provides a more complete picture of white matter structure than either imaging modality in isolation. Here we describe the regional distribution of FA and MTR measurements of pericortical white matter in 56 young, healthy right-handed subjects. Significant regional and lobar differences are seen for both measures along with a significant gender difference in FA. Highly consistent hemispheric asymmetries in FA and MTR were observed, suggesting that the greater fiber coherence and increased myelination of fibers in left hemisphere perisylvian regions may provide a structural basis for left-hemisphere language dominance.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Kang X,Herron TJ,Woods DLdoi
10.1016/j.neuroimage.2011.03.016subject
Has Abstractpub_date
2011-06-15 00:00:00pages
2011-23issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(11)00275-8journal_volume
56pub_type
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