Abstract:
:Evidence from both animal and human research suggests that the formation of emotional memories is triggered by the beta-adrenergic system. To confirm whether modulation of central beta-adrenergic transmission is specifically involved in the neural signature of memory performance, the pre-encoding effect of propranolol (80 mg) on event-related potentials (ERPs) was measured in a placebo-controlled, double-blind, parallel-group study in 46 male healthy subjects using high density EEG and source imaging analysis during encoding and retrieval (after 1 week) of IAPS pictures of unpleasant, neutral and pleasant contents; for recognition 90 old pictures were randomly mixed with 90 new pictures. During retrieval correctly remembered old pictures elicited a significantly larger positive voltage change over the centro-parietal cortex than new pictures. Propranolol significantly reduced this old/new difference of the mean ERP amplitudes (500-800 ms) for unpleasant but not for neutral and pleasant memories. This effect correlated with salivary alpha-amylase activity, a surrogate for central adrenergic stimulation. In conclusion, propranolol selectively blocked the neural signature of unpleasant memories by mechanisms in which the parietal cortex seems to be specifically involved.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Weymar M,Löw A,Modess C,Engel G,Gründling M,Petersmann A,Siegmund W,Hamm AOdoi
10.1016/j.neuroimage.2009.10.025subject
Has Abstractpub_date
2010-02-01 00:00:00pages
2800-6issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(09)01096-9journal_volume
49pub_type
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