Abstract：
:Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by atypical social communication and repetitive behaviors. In this study, we applied a multimodal approach to investigate brain structural connectivity, resting state activity, and surface area, as well as their associations with the core symptoms of ASD. Data from forty boys with ASD (mean age, 11.5 years; age range, 5.5-19.5) and forty boys with typical development (TD) (mean age, 12.3; age range, 5.8-19.7) were extracted from the Autism Brain Imaging Data Exchange II (ABIDE II) for data analysis. We found significantly decreased structural connectivity, resting state brain activity, and surface area at the occipital cortex in boys with ASD compared to boys with TD. In addition, we found that resting state brain activity and surface area in the lateral occipital cortex was negatively correlated with communication scores in boys with ASD. Our results suggest that decreased structural connectivity and resting-state brain activity in the occipital cortex may impair the integration of verbal and non-verbal communication cues in boys with ASD, thereby impacting their social development.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Jung M,Tu Y,Lang CA,Ortiz A,Park J,Jorgenson K,Kong XJ,Kong Jdoi
10.1016/j.neuroimage.2017.09.031subject
Has Abstractpub_date
2019-04-15 00:00:00pages
205-212eissn
1053-8119issn
1095-9572pii
S1053-8119(17)30779-6journal_volume
190pub_type
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