Abstract:
:Borderline personality disorder (BPD) is a severe psychiatric condition of undetermined brain underpinnings, which involves profound emotion regulation deficits and interpersonal impairment. To elucidate biopsychological markers of the disorder, we performed two studies: i.) assessing empathy and social cognition and ii.) measuring the psychophysical properties and functional brain correlates of empathic functioning in a total of fifty-one affected patients and 50 age- and gender-matched controls. In the behavioral study we applied the Multifaceted Empathy Test (MET), a new, ecologically valid measure to assess cognitive (i.e., social cognition) and emotional (i.e., empathic concern) empathy to a subset of participants. In the second study, functional Magnetic Resonance Imaging and skin conductance measurements were performed while participants took a scanner-adapted version of the MET. Patients with BPD showed impairments in cognitive and emotional empathy. Brain responses during cognitive empathy were significantly reduced in patients compared to controls in the left superior temporal sulcus and gyrus (STS/STG), where this reduction was associated with levels of intrusive symptomatology in the BPD group. During emotional empathy, patients with BPD exhibited greater brain activity than controls in the right middle insular cortex, a response that was associated with skin conductance responses in the patients. Results indicate that altered functioning of the STS/STG and insula represents pathophysiological mediators for reduced empathy in BPD, with an important role for intrusive symptomatology and levels of arousal. The findings thus support a conceptualization of BPD as involving deficits in both inferring others' mental states and being emotionally attuned to another person.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Dziobek I,Preissler S,Grozdanovic Z,Heuser I,Heekeren HR,Roepke Sdoi
10.1016/j.neuroimage.2011.05.005subject
Has Abstractpub_date
2011-07-15 00:00:00pages
539-48issue
2eissn
1053-8119issn
1095-9572pii
S1053-8119(11)00493-9journal_volume
57pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::In the General Linear Model (GLM) framework for the statistical analysis of fMRI data, the problem of temporal autocorrelations in the residual signal (after regression) has been frequently addressed in the open literature. There exist various methods for correcting the ensuing bias in the statistical testing, among w...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.07.048
更新日期:2004-11-01 00:00:00
abstract::The serotonergic system is one of the major systems targeted in the pharmacological treatment of a wide range of mood disorders including depression; however, little is known about the neurophysiological mechanisms underlying the effects of serotonin (5-HT) on affective phenomena including emotional behaviours, mood a...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2004.03.022
更新日期:2004-07-01 00:00:00
abstract::β-amyloid (Aβ) and tau pathology become increasingly prevalent with age, however, the spatial relationship between the two pathologies remains unknown. We examined local (same region) and non-local (different region) associations between these 2 aggregated proteins in 46 normal older adults using [18F]AV-1451 (for tau...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.02.051
更新日期:2017-04-15 00:00:00
abstract::Anticipatory anxiety is a complex combination of a future-oriented cognitive state, negative affect, and autonomic arousal. A dual-task paradigm of anticipation of electric shocks and a motor-learning task was used to examine the changes in neural patterns of activation associated with modulation of the cognitive stat...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1006/nimg.1999.0407
更新日期:1999-06-01 00:00:00
abstract::Multivariate supervised learning methods exhibit a remarkable ability to decode externally driven sensory, behavioral, and cognitive states from functional neuroimaging data. Although they are typically applied to task-based analyses, supervised learning methods are equally applicable to intrinsic effective and functi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.05.072
更新日期:2013-11-15 00:00:00
abstract::We take the feeling that our body belongs to us for granted. However, recent research has shown that it is possible to alter the subjective sensation of body ownership (BO) by manipulating multisensory bodily inputs. Several frontal and parietal regions are known to specifically process multisensory cues presented clo...
journal_title:NeuroImage
pub_type: 杂志文章,meta分析
doi:10.1016/j.neuroimage.2016.12.052
更新日期:2017-02-15 00:00:00
abstract::Recent brain imaging studies have shown that the neural substrates underlying the ability to infer and share the feeling of pain of other individuals overlap with the pain matrix that mediates the process of one's own pain. While there has been evidence that the neural activity mediating pain experience is influenced ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.02.025
更新日期:2007-05-15 00:00:00
abstract::Human gaze is a critical social cue that can reveal intentions and dispositions of others. The right posterior superior temporal sulcus (pSTS) is thought to be critically involved in processing eye gaze information. We combined diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) to identify...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.11.033
更新日期:2011-03-01 00:00:00
abstract::The impact of in-scanner motion on functional magnetic resonance imaging (fMRI) data has a notorious reputation in the neuroimaging community. State-of-the-art guidelines advise to scrub out excessively corrupted frames as assessed by a composite framewise displacement (FD) score, to regress out models of nuisance var...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116433
更新日期:2020-04-01 00:00:00
abstract::Previous studies have suggested age-related differences in reward-directed behavior and cerebral processes in support of the age effects. However, it remains unclear how age may influence the processing of reward magnitude. Here, with 54 volunteers (22-74 years of age) participating in the Monetary Incentive Delay Tas...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116368
更新日期:2020-02-15 00:00:00
abstract::Picture-plane inversion dramatically impairs face recognition. Behavioral and event-related potential (ERP) studies suggest that this effect takes place during perceptual encoding of the face stimulus. However, the relationship between early electrophysiological responses to upright and inverted faces and the behavior...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.04.016
更新日期:2007-07-01 00:00:00
abstract::Learning commonly requires feedback about the consequences of one's actions, which can drive learners to modify their behavior. Motivation may determine how sensitive an individual might be to such feedback, particularly in educational contexts where some students value academic achievement more than others. Thus, mot...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.06.046
更新日期:2015-10-01 00:00:00
abstract::The James-Lange theory of emotion proposes that automatically generated bodily reactions not only color subjective emotional experience of stimuli, but also necessitate a mechanism by which these bodily reactions are differentially generated to reflect stimulus quality. To examine this putative mechanism, we simultane...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2004.10.013
更新日期:2005-02-01 00:00:00
abstract::Whole brain extraction is an important pre-processing step in neuroimage analysis. Manual or semi-automated brain delineations are labour-intensive and thus not desirable in large studies, meaning that automated techniques are preferable. The accuracy and robustness of automated methods are crucial because human exper...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.12.067
更新日期:2011-04-01 00:00:00
abstract::The Human Connectome Project (HCP) faces the challenging task of bringing multiple magnetic resonance imaging (MRI) modalities together in a common automated preprocessing framework across a large cohort of subjects. The MRI data acquired by the HCP differ in many ways from data acquired on conventional 3 Tesla scanne...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.04.127
更新日期:2013-10-15 00:00:00
abstract::Proportional scaling models are often used in functional imaging studies to remove confounding of local signals by global effects. It is generally assumed that global effects are uncorrelated with experimental conditions. However, when the global effect is estimated by the global signal, defined as the intracerebral a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.03.025
更新日期:2006-08-01 00:00:00
abstract::Proton density and transverse relaxation (T2)-weighted fast spin echo images are frequently acquired. T2 quantification is commonly performed by applying an exponential fit to these two images, despite recent evidence that an exponential fit is insufficient to correctly quantify T2 in the presence of imperfect RF refo...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.05.079
更新日期:2015-09-01 00:00:00
abstract::The recording of electrophysiological data during BOLD fMRI is highly challenging but provides the opportunity to develop a more thorough account of brain function than either modality alone. To develop new techniques in this area has often required the study of pathological electrophysiological measures because such ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.04.183
更新日期:2006-08-15 00:00:00
abstract::Cerebral artery segmentation plays an important role in the direct visualization of the human brain to obtain vascular system information. On ultra-high field magnetic resonance imaging, cerebral arteries appearing hyperintense on T1 weighted (T1w) images could be segmented from brain tissues such as gray and white ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117259
更新日期:2020-11-15 00:00:00
abstract::Visual processing is a complex task which is best investigated using sensitive multivariate analysis methods that can capture representation-specific brain activity over both time and space. In this study, we applied a multivariate decoding algorithm to MEG data of subjects engaged in passive viewing of images of face...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.07.075
更新日期:2013-12-01 00:00:00
abstract::Although East Asia harbors the largest number of aging adults in the world, there is currently little data clarifying the longitudinal brain-cognition relationships in this group. Here, we report structural MRI and neuropsychological findings from relatively healthy Chinese older adults of the Singapore-Longitudinal A...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.10.016
更新日期:2017-02-15 00:00:00
abstract::Humans have the ability to choose freely between different alternatives. It is common knowledge, however, that our free choices are influenced by the environment and by past experiences. In the present study we investigated if the involvement of the medial frontal cortex, which is known to be important for intentional...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.01.052
更新日期:2013-05-15 00:00:00
abstract::Grounded cognition theories hold that the neural states involved in experiencing objects play a direct functional role in representing and accessing object knowledge from memory. However, extant data marshaled to support this view are also consistent with an opposing view that perceptuo-motor activations occur only fo...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.05.025
更新日期:2014-10-01 00:00:00
abstract::Creative thinking relies on the ability to make remote associations and fruitfully combine unrelated concepts. Hence, original associations and bi-associations (i.e., associations to one and two concepts, respectively) are considered elementary cognitive processes of creative cognition. In this work, we investigated t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116586
更新日期:2020-04-15 00:00:00
abstract::We use an fMRI adaptation paradigm to explore the selectivity of human responses in the lateral geniculate nucleus (LGN) and superior colliculus (SC) to red-green color and achromatic contrast. We measured responses to red-green (RG) and achromatic (ACH) high contrast sinewave counter-phasing rings with and without ad...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.04.067
更新日期:2016-09-01 00:00:00
abstract::ACT-R (Anderson, J.R., et al., 2003. An information-processing model of the BOLD response in symbol manipulation tasks. Psychon. Bull. Rev. 10, 241-261) relates the inferior dorso-lateral prefrontal cortex to a retrieval buffer that holds information retrieved from memory and the posterior parietal cortex to an imagin...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.11.001
更新日期:2005-03-01 00:00:00
abstract::Despite emerging evidence suggesting a biological basis to our social tiles, our understanding of the neural processes which link two minds is unknown. We implemented a novel approach, which included connectome similarity analysis using resting state intrinsic networks of parent-child dyads as well as daily diaries me...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.02.078
更新日期:2017-05-15 00:00:00
abstract::The "language-ready" brain theory suggests that the infant brain is pre-wired for language acquisition prior to language exposure. As a potential brain marker of such a language readiness, a leftward structural brain asymmetry was found in human infants for the Planum Temporale (PT), which overlaps with Wernicke's are...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117575
更新日期:2020-12-04 00:00:00
abstract::White matter thalamo-cortical fibers allow the communication of distant brain regions by carrying neuronal signals. Mapping non-invasively the information flow within white matter fibers is regarded so far as impossible. We investigated here whether information flow propagating along thalamo-cortical fibers can be det...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.01.054
更新日期:2012-04-02 00:00:00
abstract::We present a new shape-based approach for regional group activation analysis in fMRI studies. The method restricts anatomical normalization, spatial smoothing and random effects statistical analysis to the space inside and around a structure of interest. Normalization involves finding intersubject correspondences betw...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.01.029
更新日期:2007-05-01 00:00:00