Abstract：
:Neurodegeneration precedes the onset of dementias such as Alzheimer's by several years. Recent advances in volumetric imaging allow quantification of subtle neuroanatomical change over time periods as short as six months. This study investigates whether neuroanatomical change in medial temporal lobe subregions is associated with later memory decline in elderly controls. Using high-resolution, T1-weighted magnetic resonance images acquired at baseline and six-month follow-up, change in cortical thickness and subcortical volumes was measured in 142 healthy elderly subjects (aged 59-90 years) from the ADNI cohort. Regression analysis was used to identify whether change in fourteen subregions, selected a priori, was associated with declining performance on memory tests from baseline to two-year follow-up. Percent thickness change in the right fusiform and inferior temporal cortices and expansion of the right inferior lateral ventricle were found to be significant predictors of subsequent decline on memory-specific neuropsychological measures. These results demonstrate that six-month regional neurodegeneration can be quantified in the healthy elderly and might help identify those at risk for subsequent cognitive decline.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Murphy EA,Holland D,Donohue M,McEvoy LK,Hagler DJ Jr,Dale AM,Brewer JB,Alzheimer's Disease Neuroimaging Initiative.doi
10.1016/j.neuroimage.2010.07.016subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1310-7issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(10)00967-5journal_volume
53pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:Hemispheric asymmetries play an important role in multiple cerebral functions. Asymmetries in prefrontal cortex (PFC) function have been suggested to regulate emotional processing in that right-hemispheric dominance biases towards negative affect, whereas left PFC dominance favors positive affect. This study used tran...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.01.057
更新日期：2019-05-01 00:00:00
abstract：:The cognitive activity of the human brain benefits from the functional connectivity of multiple brain regions that form specific, functional brain networks. Recent studies have indicated that the relationship between brain regions can be investigated by examining the temporal interaction (known as functional connectiv...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.03.033
更新日期：2011-06-01 00:00:00
abstract：:Acute stress elicits redistribution of lymphocyte subsets, especially natural killer (NK) cells, probably for preparatory defense against potential invasion of antigens in fight-flight situations. We previously reported that regulation of lymphocyte redistribution is based on the evaluation of the controllability of a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.04.088
更新日期：2009-09-01 00:00:00
abstract：:Trace conditioning refers to a learning process occurring after repeated presentation of a neutral conditioned stimulus (CS+) and a salient unconditioned stimulus (UCS) separated by a temporal gap. Recent studies have reported that trace conditioning can occur in humans in reduced levels of consciousness by showing a ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.07.039
更新日期：2016-11-01 00:00:00
abstract：:Somatosensory stimulation (SS), leading to increases in motor cortical excitability, influences motor performance in patients with brain lesions like stroke. The mechanisms by which SS modulates motor function are incompletely understood. Here, we used functional magnetic resonance imaging (fMRI, blood-oxygenation-lev...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.05.055
更新日期：2005-10-01 00:00:00
abstract：:Psycholinguistic research has documented a range of variables that influence visual word recognition performance. Many of these variables are highly intercorrelated. Most previous studies have used factorial designs, which do not exploit the full range of values available for continuous variables, and are prone to ske...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.05.054
更新日期：2008-09-01 00:00:00
abstract：:The human infant is particularly immature at birth and brain maturation, with the myelination of white matter fibers, is protracted until adulthood. Diffusion tensor imaging offers the possibility to describe non invasively the fascicles spatial organization at an early stage and to follow the cerebral maturation with...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.11.022
更新日期：2006-05-01 00:00:00
abstract：:Neuroimaging genetics is a rapidly developing field that combines neuropsychiatric genetics studies with imaging modalities to investigate how genetic variation influences brain structure and function. As both genetic and imaging technologies improve further, their combined power may hold translational potential in te...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117208
更新日期：2020-11-01 00:00:00
abstract：:Volumetric measurements obtained from image parcellation have been instrumental in uncovering structure-function relationships. However, anatomical study of the cerebellum is a challenging task. Because of its complex structure, expert human raters have been necessary for reliable and accurate segmentation and parcell...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.08.075
更新日期：2013-01-01 00:00:00
abstract：:The important roles played by the A(1) adenosine receptor (A(1)AR) in brain physiology and pathology make this receptor a target for in vivo imaging. Here we describe the distribution of A(1)ARs in the living human brain with PET, made possible for the first time by the highly potent and selective A(1)AR antagonist 8-...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/s1053-8119(03)00241-6
更新日期：2003-08-01 00:00:00
abstract：:We used whole-head functional magnetic resonance imaging (fMRI) to investigate the effect of switching between different sequential and repetitive movements in the context of conditional and fixed tasks. Four different movement tasks were applied: (1) unpredictable switching between two movement sequences comprising s...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2000.0626
更新日期：2000-11-01 00:00:00
abstract：:Connectome mapping using techniques such as functional magnetic resonance imaging (fMRI) has become a focus of systems neuroscience. There remain many statistical challenges in analysis of functional connectivity and network architecture from BOLD fMRI multivariate time series. One key statistic for any time series is...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.04.052
更新日期：2016-11-15 00:00:00
abstract：:Nonrigid registration and atlas-based parcellation methods were used to compare the volume of the ventricular system and the cross-sectional area of the midsagittal corpus callosum on brain MRIs from 272 subjects in four groups: patients with HIV infection, with and without alcoholism comorbidity, alcoholics, and cont...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.05.052
更新日期：2006-10-15 00:00:00
abstract：:Electrocorticography (ECoG), electrophysiological recording from the pial surface of the brain, is a critical measurement technique for clinical neurophysiology, basic neurophysiology studies, and demonstrates great promise for the development of neural prosthetic devices for assistive applications and the treatment o...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.04.027
更新日期：2018-08-01 00:00:00
abstract：:The cerebral cortex modulates early sensory processing via feed-back connections to sensory pathway nuclei. The functions of this top-down modulation for human behavior are poorly understood. Here, we show that top-down modulation of the visual sensory thalamus (the lateral geniculate body, LGN) is involved in visual-...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.05.032
更新日期：2018-09-01 00:00:00
abstract：:Economic decision-making involves the weighting of magnitude and probability of potential gains/losses. While previous work has examined the neural systems involved in decision-making, there is a need to understand how the parameters associated with decision-making (e.g., magnitude of expected reward, probability of e...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.08.016
更新日期：2009-01-15 00:00:00
abstract：:Multiecho T(2) relaxation measurements offer specific information about myelin content through the myelin water fraction (MWF), as well as about the water environments through the intra- and extra-cellular (IE), and global, geometric mean T(2) (GMT(2)) times. While these measurements have yielded new insights into bra...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.08.076
更新日期：2011-01-15 00:00:00
abstract：:In line with the notion of a continuously active and dynamic brain, functional networks identified during rest correspond with those revealed by task-fMRI. Characterizing the dynamic cross-talk between these network nodes is key to understanding the successful implementation of effortful cognitive processing in health...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.01.026
更新日期：2015-04-01 00:00:00
abstract：:The female brain contains a larger proportion of gray matter tissue, while the male brain comprises more white matter. Findings like these have sparked increasing interest in studying dimorphism of the human brain: the general effect of gender on aspects of brain architecture. To date, the vast majority of imaging stu...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.12.068
更新日期：2013-04-15 00:00:00
abstract：:Cortical activity evoked by repeated identical sensory stimulation is extremely variable. The source of this variability is often assigned to "random ongoing background activity" which is considered to be irrelevant to the processing of the stimuli and can therefore be eliminated by ensemble averaging. In this work, w...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/S1053-8119(03)00367-7
更新日期：2003-10-01 00:00:00
abstract：:The aim of this work is to develop a new framework for multi-object segmentation of deep brain structures (caudate nucleus, putamen and thalamus) in medical brain images. Deep brain segmentation is difficult and challenging because the structures of interest are of relatively small size and have significant shape vari...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.03.010
更新日期：2009-07-15 00:00:00
abstract：:In a previous study, a three-dimensional (3D) MRI atlas of the human cerebellar nuclei was introduced based on findings in one healthy human subject [Dimitrova, A., Weber, J., Redies, C., Kindsvater, K., Maschke, M., Kolb, F.P., Forsting, M., Diener, H.C., Timmann, D., 2002. MRI atlas of the human cerebellar nuclei. N...
journal_title：NeuroImage
pub_type： 评论,杂志文章
doi：10.1016/j.neuroimage.2005.09.020
更新日期：2006-03-01 00:00:00
abstract：:We use a computational neuroscience approach to study the role of feature-based attention in visual perception. This model is used to numerically simulate a visual attention experiment. The neurodynamical system consists of many interconnected modules that can be related to the dorsal and ventral paths of the visual c...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2003.08.045
更新日期：2004-01-01 00:00:00
abstract：:Functional positron emission tomography (fPET) is a neuroimaging method involving continuous infusion of 18-F-fluorodeoxyglucose (FDG) radiotracer during the course of a PET examination. Compared with the conventional bolus administration of FDG in a static PET scan, which provides an average glucose uptake into the b...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.116720
更新日期：2020-06-01 00:00:00
abstract：:Facial emotions express our internal states and are fundamental in social interactions. Here we explore whether the repetition of unattended facial emotions builds up a predictive representation of frequently encountered emotions in the visual system. Participants (n=24) were presented peripherally with facial stimuli...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.10.041
更新日期：2012-02-01 00:00:00
abstract：:The temporal structure of self-generated cognition is a key attribute to the formation of a meaningful stream of consciousness. When at rest, our mind wanders from thought to thought in distinct mental states. Despite the marked importance of ongoing mental processes, it is challenging to capture and relate these stat...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.03.029
更新日期：2019-07-01 00:00:00
abstract：:Attention-related amplification of neural representations of external stimuli has been well documented in the visual domain, however, research concerning the oscillatory dynamics of such directed attention is relatively sparse in humans. Specifically, it is unknown which spectrally-specific neural responses are mainly...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.116927
更新日期：2020-08-15 00:00:00
abstract：:The amygdala (AMG) has been repeatedly implicated in the processing of threatening and negatively valenced stimuli and multiple fMRI paradigms have reported personality, genetic, and psychopathological associations with individual differences in AMG activation in these paradigms. Yet the interchangeability of activati...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.11.038
更新日期：2017-02-01 00:00:00
abstract：:Recent advances in machine learning allow faster training, improved performance and increased interpretability of classification techniques. Consequently, their application in neuroscience is rapidly increasing. While classification approaches have proved useful in functional magnetic resonance imaging (fMRI) studies,...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.06.076
更新日期：2018-11-01 00:00:00
abstract：:Spherical deconvolution methods have been applied to diffusion MRI to improve diffusion tensor tractography results in brain regions with multiple fibre crossing. Recent developments, such as the introduction of non-negative constraints on the solution, allow a more accurate estimation of fibre orientations by reducin...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.09.033
更新日期：2010-01-15 00:00:00
