Abstract：
:This article has been written in response to Dr. Fred L. Bookstein's article entitled '"Voxel-Based Morphometry" Should Not Be Used with Imperfectly Registered Images' in this issue of NeuroImage. We will address three main issues: (i) Dr. Bookstein appears to have misunderstood the objective of voxel-based morphometry (VBM) and the nature of the continuum we referred to. (ii) We agree with him when he states that findings from VBM can pertain to systematic registration errors during spatial normalization. (iii) His argument about voxelwise tests on smooth data holds in the absence of error variance, but is of no consequence when using actual data. We first review the tenets of VBM, paying particular attention to the relationship between VBM and tensor-based morphometry. The last two sections of this response deal with the specific concerns raised by Dr. Bookstein.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Ashburner J,Friston KJdoi
10.1006/nimg.2001.0961keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
1238-43issue
6eissn
1053-8119issn
1095-9572pii
S1053-8119(01)90961-9journal_volume
14pub_type
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