Abstract：
:Amnestic mild cognitive impairment (aMCI) can be classified into single domain (S-aMCI) and multiple domain (M-aMCI) subtypes. However, there have been no studies that specifically investigate the structural differences that support this classification. In an attempt to compare regional cortical thickness in two subtypes of aMCI, we aimed to map the distribution of cortical thinning using a surface based cortical analysis of magnetic resonance imaging. The cortical thickness across the entire brain was measured in 9 patients with S-aMCI, 22 patients with M-aMCI, and 61 normal healthy subjects. Differences in the patterns of cortical thinning between S-aMCI and M-aMCI were assessed using ANCOVA on a vertex-by-vertex basis, and statistical maps of differences in cortical thickness between the groups were constructed using a surface model. Relative to controls, S-aMCI patients showed cortical thinning in the left medial temporal lobe, and M-aMCI patients showed cortical thinning in the left medial temporal lobe, precuneus, and anterior and inferior basal temporal, insular, and temporal association cortices. When the two MCI groups were directly compared, M-aMCI patients showed cortical thinning in left precuneus. Our studies suggest that M-aMCI is a transitional state between S-aMCI and Alzheimer's disease, and that the cortical thinning is evidence that the precuneus is responsible for the multiple cognitive impairments in M-aMCI.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Seo SW,Im K,Lee JM,Kim YH,Kim ST,Kim SY,Yang DW,Kim SI,Cho YS,Na DLdoi
10.1016/j.neuroimage.2007.02.042subject
Has Abstractpub_date
2007-06-01 00:00:00pages
289-97issue
2eissn
1053-8119issn
1095-9572pii
S1053-8119(07)00160-7journal_volume
36pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:During auditory perception, we are required to abstract information from complex temporal sequences such as those in music and speech. Here, we investigated how higher-order statistics modulate the neural responses to sound sequences, hypothesizing that these modulations are associated with higher levels of the peri-S...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.10.038
更新日期：2011-02-01 00:00:00
abstract：:Classical fear conditioning is an important mechanism to adequately respond and adapt to environmental threats and has been related to the development of fear and anxiety. Both cue and context conditioning have been studied but little is known about their relation to relevant resting state networks. The default mode n...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.10.024
更新日期：2018-01-15 00:00:00
abstract：:To what extent free response generation in different tasks uses common and task-specific neurocognitive processes has remained unclear. Here, we investigated overlap and differences in neural activity during musical improvisation and pseudo-random response generation. Brain activity was measured using fMRI in a group ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.07.016
更新日期：2012-01-02 00:00:00
abstract：:The organization of tonotopic fields in human auditory cortex was investigated using functional magnetic resonance imaging. Subjects were presented with stochastically alternating multi-tone sequences in six different frequency bands, centered at 200, 400, 800, 1600, 3200, and 6400 Hz. Two mirror-symmetric frequency g...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.01.046
更新日期：2010-04-15 00:00:00
abstract：:In line with the notion of a continuously active and dynamic brain, functional networks identified during rest correspond with those revealed by task-fMRI. Characterizing the dynamic cross-talk between these network nodes is key to understanding the successful implementation of effortful cognitive processing in health...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.01.026
更新日期：2015-04-01 00:00:00
abstract：:The outcome of Statistical Parametric Mapping (SPM) analyses of PET activation studies depends among others, on the quality of reconstructed data. In general, filtered back-projection (FBP) is used for reconstruction in PET activation studies. There is, however, increasing interest in iterative reconstruction algorith...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/S1053-8119(03)00379-3
更新日期：2003-10-01 00:00:00
abstract：:In any non-deterministic environment, unexpected events can indicate true changes in the world (and require behavioural adaptation) or reflect chance occurrence (and must be discounted). Adaptive behaviour requires distinguishing these possibilities. We investigated how humans achieve this by integrating high-level in...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.08.057
更新日期：2017-02-01 00:00:00
abstract：:A voluntary head motion suppression method using feedback to subjects of their own head motion information is demonstrated. A real-time fMRI system was developed on standard MR imaging hardware for this purpose. The head motion information was simplified as a four-way arrow display that changed color from green to red...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.02.050
更新日期：2005-08-01 00:00:00
abstract：:One of the most important considerations in any hypothesis based fMRI data analysis is to choose the appropriate threshold to construct the activation maps, which is usually based on p-values. However, in fMRI data, there are three factors which necessitate severe corrections in the process of estimating the p-values....
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.10.025
更新日期：2007-02-15 00:00:00
abstract：:We used functional Magnetic Resonance Imaging to explore the neural correlates of semantic relevance in 12 healthy participants performing a picture-naming task. In addition, we tested the hypothesis that category effects typically found in functional imaging can be partly explained in terms of different semantic rele...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.10.017
更新日期：2006-04-15 00:00:00
abstract：:Multi-band echo planar imaging (MB-EPI), a new approach to increase data acquisition efficiency and/or temporal resolution, has the potential to overcome critical limitations of standard acquisition strategies for obtaining high-resolution whole brain perfusion imaging using arterial spin labeling (ASL). However, the ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.10.029
更新日期：2015-02-01 00:00:00
abstract：:When a head is placed in an MRI scanner, differences between the magnetic susceptibility of tissue, bone, and air distort the magnetic field. While some of the resulting inhomogeneity can be corrected by the shimming process, much of it cannot, and this causes distortion (sometimes referred to as geometric distortion)...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2002.1281
更新日期：2003-01-01 00:00:00
abstract：:Diffuse optical tomography is most accurate when an individual's MRI data can be used as a spatial prior for image reconstruction and for visualization of the resulting images of changes in oxy- and deoxy-hemoglobin concentration. As this necessitates an MRI scan to be performed for each study, which undermines many o...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.06.028
更新日期：2014-10-15 00:00:00
abstract：:The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal spatial covariance pattern involving basal ganglia thalamocortical pathways. By contrast, little is known about the functional networks that underlie cognitive dysfunction in this disorder. To identify such patterns, we studied 15 non...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.09.003
更新日期：2007-01-15 00:00:00
abstract：:Humans experience a sense of self, which is proposed to emerge from the integration of intrinsic and extrinsic self-processing through the propagation of information across brain systems. Using a novel functional magnetic resonance imaging (fMRI) paradigm, we tested this hypothesis in a non-clinical sample by modulati...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.116284
更新日期：2020-01-15 00:00:00
abstract：:Cortical plasticity is thought to occur following continuous barrage of nociceptive afferent signals to the brain. Hence, chronic pain is presumed to induce anatomical and physiological changes in the brain over time. Inherent factors, some pre-dating the onset of chronic pain, may also contribute to brain abnormaliti...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.12.013
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). METHODS:We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.03.026
更新日期：2015-06-01 00:00:00
abstract：:Electroencephalographic (EEG) and magnetoencephalographic (MEG) signals can often be exposed to strong power line interference at 50 or 60 Hz. A widely used method to remove line noise is the notch filter, but it comes with the risk of potentially severe signal distortions. Among other approaches, the Discrete Fourier...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.01.026
更新日期：2019-04-01 00:00:00
abstract：:Dynamic functional connectivity (DFC) aims to maximize resolvable information from functional brain scans by considering temporal changes in network structure. Recent work has demonstrated that static, i.e. time-invariant resting-state and task-based FC predicts individual differences in behavior, including attention....
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.11.057
更新日期：2019-03-01 00:00:00
abstract：:Processing speed is an important construct in understanding cognition. This study was aimed to control task specificity for understanding the neural mechanisms underlying cognitive processing speed. Forty young adult subjects performed attention tasks of two modalities (auditory and visual) and two levels of task rule...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117556
更新日期：2021-02-01 00:00:00
abstract：:Recent advances in machine learning allow faster training, improved performance and increased interpretability of classification techniques. Consequently, their application in neuroscience is rapidly increasing. While classification approaches have proved useful in functional magnetic resonance imaging (fMRI) studies,...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.06.076
更新日期：2018-11-01 00:00:00
abstract：:We analyzed the putative association between abdominal obesity (measured in waist circumference) and gray matter volume (Study of Health in Pomerania: SHIP-2, N=758) adjusted for age and gender by applying volumetric analysis and voxel-based morphometry (VBM) with VBM8 to brain magnetic resonance (MR) imaging. We soug...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.07.086
更新日期：2015-11-15 00:00:00
abstract：:Comparing the neural outcomes of two randomized experimental groups is a primary aim of many functional neuroimaging studies. However, between-group effects can be obscured by heterogeneity in neural responses. Optimal Combined Moderator (OCM) approaches have previously been used to clarify heterogeneity in clinical o...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.07.051
更新日期：2018-11-01 00:00:00
abstract：:Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperature magnetoencephalography (MEG), with a greatly increased flexibility of sensor placement...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.01.034
更新日期：2017-04-01 00:00:00
abstract：:Although analogical reasoning (AR) plays a central role in higher-level cognition and constitutes a key source of individual differences in intellectual ability, the neural mechanisms that account for individual differences in AR remain to be well characterized. Here we investigated individual differences in AR within...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.09.011
更新日期：2019-01-01 00:00:00
abstract：:Cerebrovascular reactivity (CVR) is a mechanism responsible for maintaining stable perfusion pressure within the brain via smooth muscle mediated modulations of vascular tone. The amplitude of cerebral blood flow (CBF) change in response to a stimulus has been evaluated using Blood Oxygen Level Dependent (BOLD) MRI, h...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.05.006
更新日期：2014-09-01 00:00:00
abstract：:Although, on average, the magnitude of alpha oscillations (8 to 12 Hz) is decreased in task-relevant cortices during externally oriented attention, its fluctuations have significant consequences, with increased level of alpha associated with decreased level of visual processing and poorer behavioral performance. Funct...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.11.058
更新日期：2013-03-01 00:00:00
abstract：:Semantic processing entails the activation of widely distributed brain areas across the temporal, parietal, and frontal lobes. To understand the functional structure of this semantic system, we examined its intrinsic functional connectivity pattern using a database of 146 participants. Focusing on areas consistently a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.03.004
更新日期：2016-05-15 00:00:00
abstract：:Reporting white matter findings in voxel-wise neuroimaging studies typically lacks specificity in terms of brain connectivity. Therefore, the purpose of this work was to develop an approach for rapidly extracting standardized brain connectivity information for white matter regions with significant findings in voxel-wi...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117462
更新日期：2021-01-15 00:00:00
abstract：:We present methods for the quantitative analysis of brain growth based on the registration of longitudinal MR image data with the use of Jacobian determinant maps to characterise neuroanatomical changes. The individual anatomies, growth maps and tissue classes are also spatially normalised in an 'average space' and ag...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.07.067
更新日期：2008-01-01 00:00:00
