Abstract:
:One of the most important considerations in any hypothesis based fMRI data analysis is to choose the appropriate threshold to construct the activation maps, which is usually based on p-values. However, in fMRI data, there are three factors which necessitate severe corrections in the process of estimating the p-values. First, the fMRI time series at an individual voxel has strong temporal autocorrelation which needs to be estimated to obtain the corrected parametric p-value. The second factor is the multiple comparisons problem arising from simultaneously testing tens of thousands of voxels for activation. A common way in the statistical literature to account for multiple testing is to consider the family-wise error rate (FWE) which is related to the distribution of the maximum observed value over all voxels. The third problem, which is not mentioned frequently in the context of adjusting the p-value, is the effect of inherent low frequency processes present even in resting-state data that may introduce a large number of false positives without proper adjustment. In this article, a novel and efficient semi-parametric method, using resampling of normalized spacings of order statistics, is introduced to address all the three problems mentioned above. The new method makes very few assumptions and demands minimal computational effort, unlike other existing resampling methods in fMRI. Furthermore, it will be demonstrated that the correction for temporal autocorrelation is not critical in implementing the proposed method. Results using the proposed method are compared with SPM2.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Nandy R,Cordes Ddoi
10.1016/j.neuroimage.2006.10.025subject
Has Abstractpub_date
2007-02-15 00:00:00pages
1562-76issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(06)01022-6journal_volume
34pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::Resting-state functional connectivity, manifested as spontaneous synchronous activity in the brain, has been detected by functional MRI (fMRI) across species such as humans, monkeys, and rats. Yet, most networks, especially the classical bilateral connectivity between hemispheres, have not been reliably found in the m...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.10.025
更新日期:2014-02-01 00:00:00
abstract::MRI based on T1 relaxation contrast is increasingly being used to study brain morphology and myelination. Although it provides for excellent distinction between the major tissue types of gray matter, white matter, and CSF, reproducible quantification of T1 relaxation rates is difficult due to the complexity of the con...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.12.032
更新日期:2016-03-01 00:00:00
abstract::Classical fear conditioning is an important mechanism to adequately respond and adapt to environmental threats and has been related to the development of fear and anxiety. Both cue and context conditioning have been studied but little is known about their relation to relevant resting state networks. The default mode n...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.10.024
更新日期:2018-01-15 00:00:00
abstract::Gradient echo techniques are often hampered by signal dephasing due to macroscopic phase perturbations because of system imperfections (shimming) or object induced perturbations of the magnetic field (hemorrhagic lesions, calcified tissue, air-tissue interfaces). Many techniques have been proposed to reduce the effect...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.11.083
更新日期:2012-03-01 00:00:00
abstract::The two commonest, clinically well-defined, forms of parkinsonism are idiopathic Parkinson's disease (PD) and progressive supranuclear palsy (PSP). Both involve, inter alia, pathological changes in the substantia nigra pars compacta (SN(C)). In PD there is neuronal loss with associated Lewy body pathology and microgli...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2003.07.012
更新日期:2003-11-01 00:00:00
abstract::There has been extensive work using early event-related potentials (ERPs) to study visual object processing. ERP analyses focus traditionally on mean amplitude differences, with the implicit assumption that all of the neuronal activity of interest is evoked by the stimulus in a time-locked manner from trial to trial. ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.02.052
更新日期:2007-07-01 00:00:00
abstract::Cancer and cancer treatment-related neurocognitive dysfunction (CRND) (e.g., impairments in key cognitive domains of attention, memory, processing speed, and executive function), commonly referred to as "chemobrain" or "chemo-fog", can negatively impact patients' psychosocial functioning and quality of life. CRND is a...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2013.06.075
更新日期:2014-01-15 00:00:00
abstract::Probing microstructure with diffusion magnetic resonance imaging (dMRI) on a scale orders of magnitude below the imaging resolution relies on biophysical modelling of the signal response in the tissue. The vast majority of these biophysical models of diffusion in white matter assume that the measured dMRI signal is th...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116460
更新日期:2020-03-01 00:00:00
abstract::An event-related protocol was designed to permit auditory fMRI studies minimally affected by the echo-planar noise artifact; a long time interval (TR = 10 s) between each cerebral volume acquisition was combined with stroboscopic data acquisition, and event-related curves were reconstructed with a 1-s resolution. The ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1999.0480
更新日期:1999-10-01 00:00:00
abstract::Essential tremor is effectively treated with deep brain stimulation (DBS), but the neural mechanisms underlying the treatment effect are poorly understood. Essential tremor is driven by a dysfunctional cerebello-thalamo-cerebral circuit resulting in pathological tremor oscillations. DBS is hypothesised to interfere wi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116511
更新日期:2020-04-01 00:00:00
abstract::In order to act in a socially acceptable way, the ability to forgive is indispensable. It has been suggested that forgiveness relies on cognitive control, more specifically inhibition. In this study, we combined an ultimatum game (UG) and a dictator game (DG) with inhibitory, continuous theta-burst stimulation (cTBS; ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.08.065
更新日期:2018-12-01 00:00:00
abstract::In-vivo volumetric measurements of hippocampus have proven to be highly informative for studying various neurological diseases such as Alzheimer's disease. The usefulness of volumetric imaging, however, has been limited due to the poor image resolutions obtained by currently available MRI images. In this study, a new ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.11.002
更新日期:2010-02-01 00:00:00
abstract::Tool use is one of the most remarkable skills of the human species, enabling complex interactions with the environment. To establish such interactions, we predict the sensory consequences of our actions based on a copy of the motor command (efference copy), leading to an attenuated perception and neural suppression of...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116309
更新日期:2020-02-01 00:00:00
abstract::Attention-related amplification of neural representations of external stimuli has been well documented in the visual domain, however, research concerning the oscillatory dynamics of such directed attention is relatively sparse in humans. Specifically, it is unknown which spectrally-specific neural responses are mainly...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116927
更新日期:2020-08-15 00:00:00
abstract::Over the last two decades, numerous human MRI studies of neuroplasticity have shown compelling evidence for extensive and rapid experience-induced brain plasticity in vivo. To date, most of these studies have consisted of simply detecting a difference in structural or functional images with little concern for their la...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2015.08.047
更新日期:2016-05-01 00:00:00
abstract::Complex tasks often require the memory of recent events, the knowledge about the context in which they occur, and the goals we intend to reach. All this information is stored in our mental states. Given a set of mental states, reinforcement learning (RL) algorithms predict the optimal policy that maximizes future rewa...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.01.047
更新日期:2010-09-01 00:00:00
abstract::There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during ra...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.01.017
更新日期:2013-05-01 00:00:00
abstract::Although analogical reasoning (AR) plays a central role in higher-level cognition and constitutes a key source of individual differences in intellectual ability, the neural mechanisms that account for individual differences in AR remain to be well characterized. Here we investigated individual differences in AR within...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.09.011
更新日期:2019-01-01 00:00:00
abstract::One hypothesis on how we recognize an image of, for example, an arm as our own is through the co-occurrence of multiple sensory feedbacks, especially visual and proprioceptive feedbacks, in this process. It has been suggested that the parietal lobe is the region where proprioceptive and visual information of one's own...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2004.10.039
更新日期:2005-02-15 00:00:00
abstract::Understanding the differences between individuals' personality types at a functional brain level is now possible due to recent developments in both functional brain imaging and personality models. The psychobiological model for temperament and character offers one approach to exploring personality. This study uses SPE...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/s1053-8119(03)00171-x
更新日期:2003-07-01 00:00:00
abstract::This study introduces a direct method of assessing cerebral lateralization for language based on fMRI activation. The method, derived from a voxel-based morphometry study by C. H. Salmond et al. (2000, Hum. Brain Mapping 11, 223-232), bases lateralization on the direct statistical comparison of the magnitude of task-i...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2002.1327
更新日期:2002-12-01 00:00:00
abstract::Regularity of laminar origin and termination of projections appears to be a common feature of corticocortical connections. We tested three models of this regularity, originally formulated for primate cerebral cortex, using quantitative data on the relative supragranular layer origins (SGN%) of 151 projections from 19 ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.03.006
更新日期:2010-07-01 00:00:00
abstract::The core concept within the field of brain mapping is the use of a standardized, or "stereotaxic", 3D coordinate frame for data analysis and reporting of findings from neuroimaging experiments. This simple construct allows brain researchers to combine data from many subjects such that group-averaged signals, be they s...
journal_title:NeuroImage
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuroimage.2012.01.024
更新日期:2012-08-15 00:00:00
abstract::Although numbers carry averbal semantics (i.e., magnitude), they are often utilized in verbal Working Memory (vWM) tasks. However, vWM is thought to rely on a purely phonological code. Here, we tested the influence of (a) averbal semantics and (b) different tasks on performance in a vWM context by examining stimulus a...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2005.07.009
更新日期:2006-01-01 00:00:00
abstract::A major limitation to structural and functional MRI (fMRI) scans is their susceptibility to head motion artifacts. Even submillimeter movements can systematically distort functional connectivity, morphometric, and diffusion imaging results. In patient care, sedation is often used to minimize head motion, but it incurs...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.01.023
更新日期:2018-05-01 00:00:00
abstract::Conventional diffusion imaging uses pulsed gradient spin echo (PGSE) waveforms with diffusion times of tens of milliseconds (ms) to infer differences of white matter microstructure. The combined use of these long diffusion times with short diffusion times (<10 ms) enabled by oscillating gradient spin echo (OGSE) wave...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116533
更新日期:2020-04-15 00:00:00
abstract::Accumulating evidence suggests that altered cerebral white matter (WM) influences normal aging, and further that WM degeneration may modulate the clinical expression of Alzheimer's disease (AD). Here we conducted a study of differences in WM volume across the adult age span and in AD employing a newly developed, autom...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.10.030
更新日期:2009-02-15 00:00:00
abstract::The ability to learn associations between stimuli, responses and rewards is a prerequisite for survival. Models of reinforcement learning suggest that the striatum, a basal ganglia input nucleus, vitally contributes to these learning processes. Our recently presented computational model predicts, first, that not only ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.07.061
更新日期:2015-11-15 00:00:00
abstract::The amygdala plays a key role in emotional processing. The specific contribution of the amygdala during the experience of one's own emotion, however, remains controversial and requires clarification. There is a long-standing debate on hemispheric lateralization of emotional processes, yet few studies to date directly ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.10.013
更新日期:2011-02-01 00:00:00
abstract::This work proposes to use magnetoencephalography (MEG) and electroencephalography (EEG) source imaging to provide cinematic representations of the temporal dynamics of cortical activations. Cortical activation maps, seen as images of the active brain, are scalar maps defined at the vertices of a triangulated cortical ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.09.087
更新日期:2011-02-01 00:00:00