A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability.

Abstract:

:There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during rat neurodevelopment remain to be elucidated. This work establishes the first magnetic resonance histology (MRH) atlas of the developing rat brain, with an emphasis on quantitation. The atlas comprises five specimens at each of nine time points, imaged with eight distinct MR contrasts and segmented into 26 developmentally defined brain regions. The atlas was used to establish a timeline of morphometric changes and variability throughout neurodevelopment and represents a quantitative database of rat neurodevelopment for characterizing rat models of human neurologic disease.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Calabrese E,Badea A,Watson C,Johnson GA

doi

10.1016/j.neuroimage.2013.01.017

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

196-206

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(13)00064-5

journal_volume

71

pub_type

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