Cracking Ali Baba's code.

abstract：:Studies of the performance of individuals with dyslexia in perceptual tasks suggest that their implicit inference of sound statistics is impaired. Previously, using two-tone frequency discrimination, we found that the effect of previous trials' frequencies on the judgments of individuals with dyslexia decays faster th...

journal_title：eLife

authors： Jaffe-Dax S,Kimel E,Ahissar M

更新日期：2018-02-28 00:00:00

abstract：:IQ scores are correlated with the morphology and activity of certain neurons in the human temporal cortex. ...

journal_title：eLife

authors： Miller EN,Sherwood CC

更新日期：2019-02-05 00:00:00

abstract：:Cell lineages provide the framework for understanding how cell fates are decided during development. Describing cell lineages in most organisms is challenging; even a fruit fly larva has ~50,000 cells and a small mammal has >1 billion cells. Recently, the idea of applying CRISPR to induce mutations during development,...

journal_title：eLife

authors： Salvador-Martínez I,Grillo M,Averof M,Telford MJ

更新日期：2019-01-28 00:00:00

abstract：:Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs the development of a committed bone marrow precursor that differ...

journal_title：eLife

authors： Yu X,Wang Y,Deng M,Li Y,Ruhn KA,Zhang CC,Hooper LV

更新日期：2014-10-13 00:00:00

abstract：:Accurate chromosome segregation relies on bioriented amphitelic attachments of chromosomes to microtubules of the mitotic spindle, in which sister chromatids are connected to opposite spindle poles. BUB-1 is a protein of the Spindle Assembly Checkpoint (SAC) that coordinates chromosome attachment with anaphase onset. ...

journal_title：eLife

authors： Edwards F,Maton G,Gareil N,Canman JC,Dumont J

更新日期：2018-12-14 00:00:00

abstract：:The risk of developing cancer is correlated with body size and lifespan within species. Between species, however, there is no correlation between cancer and either body size or lifespan, indicating that large, long-lived species have evolved enhanced cancer protection mechanisms. Elephants and their relatives (Probosc...

journal_title：eLife

authors： Vazquez JM,Lynch VJ

更新日期：2021-01-29 00:00:00

abstract：:When a human catches a ball, they estimate future target location based on the current trajectory. How animals, small and large, encode such predictive processes at the single neuron level is unknown. Here we describe small target-selective neurons in predatory dragonflies that exhibit localized enhanced sensitivity f...

journal_title：eLife

authors： Wiederman SD,Fabian JM,Dunbier JR,O'Carroll DC

更新日期：2017-07-25 00:00:00

abstract：:Excitatory and inhibitory synapses are the brain's most abundant synapse types. However, little is known about their formation during critical periods of motor skill learning, when sensory experience defines a motor target that animals strive to imitate. In songbirds, we find that exposure to tutor song leads to elimi...

journal_title：eLife

authors： Huang Z,Khaled HG,Kirschmann M,Gobes SM,Hahnloser RH

更新日期：2018-10-25 00:00:00

abstract：:The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literat...

journal_title：eLife

authors： Guthman EM,Garcia JD,Ma M,Chu P,Baca SM,Smith KR,Restrepo D,Huntsman MM

更新日期：2020-01-09 00:00:00

abstract：:Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, hepatic Lrh-1-null m...

journal_title：eLife

authors： Mamrosh JL,Lee JM,Wagner M,Stambrook PJ,Whitby RJ,Sifers RN,Wu SP,Tsai MJ,Demayo FJ,Moore DD

更新日期：2014-04-15 00:00:00

abstract：:Secondary metabolites have a great potential as pharmaceuticals, but there are only a few examples where regulation of gene cluster expression has been correlated with ecological and physiological relevance for the producer. Here, signals, mediators, and biological effects of terrein production were studied in the fun...

journal_title：eLife

authors： Gressler M,Meyer F,Heine D,Hortschansky P,Hertweck C,Brock M

更新日期：2015-07-14 00:00:00

abstract：:Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactio...

journal_title：eLife

authors： Bawa S,Brooks DS,Neville KE,Tipping M,Sagar MA,Kollhoff JA,Chawla G,Geisbrecht BV,Tennessen JM,Eliceiri KW,Geisbrecht ER

更新日期：2020-03-30 00:00:00

abstract：:Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome. Here, we show that Srsf10 expression is controlled through an autoregulated minor intron, tightly co...

journal_title：eLife

authors： Meinke S,Goldammer G,Weber AI,Tarabykin V,Neumann A,Preussner M,Heyd F

更新日期：2020-04-27 00:00:00

abstract：:Although the wiring of the cerebellar cortex appears to be uniform, the neurons in this region of the brain behave more differently from each other than previously thought. ...

journal_title：eLife

authors： Albergaria C,Carey MR

更新日期：2014-06-10 00:00:00

abstract：:Increasing evidence highlights the important roles of microRNAs in mediating p53's tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein i...

journal_title：eLife

authors： Cao B,Wang K,Liao JM,Zhou X,Liao P,Zeng SX,He M,Chen L,He Y,Li W,Lu H

更新日期：2016-07-07 00:00:00

abstract：:The asymmetric outer membrane (OM) of Gram-negative bacteria functions as a selective permeability barrier to the environment. Perturbations to OM lipid asymmetry sensitize the cell to antibiotics. As such, mechanisms involved in lipid asymmetry are fundamental to our understanding of OM lipid homeostasis. One such me...

journal_title：eLife

authors： Powers MJ,Simpson BW,Trent MS

更新日期：2020-09-03 00:00:00

abstract：:Slo2 potassium channels play important roles in neuronal function, and their mutations in humans may cause epilepsies and cognitive defects. However, it is largely unknown how Slo2 is regulated by other proteins. Here we show that the function of C. elegans Slo2 (SLO-2) depends on adr-1, a gene important to RNA editin...

journal_title：eLife

authors： Niu LG,Liu P,Wang ZW,Chen B

更新日期：2020-04-21 00:00:00

abstract：:Our understanding of nonlinear stimulus transformations by neural circuits is hindered by the lack of comprehensive yet interpretable computational modeling frameworks. Here, we propose a data-driven approach based on deep neural networks to directly model arbitrarily nonlinear stimulus-response mappings. Reformulatin...

journal_title：eLife

authors： Keshishian M,Akbari H,Khalighinejad B,Herrero JL,Mehta AD,Mesgarani N

更新日期：2020-06-26 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growt...

journal_title：eLife

authors： Tenente IM,Hayes MN,Ignatius MS,McCarthy K,Yohe M,Sindiri S,Gryder B,Oliveira ML,Ramakrishnan A,Tang Q,Chen EY,Petur Nielsen G,Khan J,Langenau DM

更新日期：2017-01-12 00:00:00

abstract：:Cancer prevention is predicted to result in more positive therapeutic outcomes than post-diagnostic interventions, and so may be a viable option for future personalized medicine. ...

journal_title：eLife

authors： Komarova NL

更新日期：2015-08-05 00:00:00

abstract：:We recently implemented a bioinformatics pipeline that can uncover novel, but rare, riboswitch candidates as well as other noncoding RNA structures in bacteria. A prominent candidate revealed by our initial search efforts was called the 'thiS motif' because of its frequent association with a gene coding for the ThiS p...

journal_title：eLife

authors： Atilho RM,Mirihana Arachchilage G,Greenlee EB,Knecht KM,Breaker RR

更新日期：2019-04-05 00:00:00

abstract：:Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround and support the tooth, and microbiome dysbiosis. Currently, there is no therapy for reversing periodontal disease, and treatment is generally restricted to preventive mea...

journal_title：eLife

authors： An JY,Kerns KA,Ouellette A,Robinson L,Morris HD,Kaczorowski C,Park SI,Mekvanich T,Kang A,McLean JS,Cox TC,Kaeberlein M

更新日期：2020-04-28 00:00:00

abstract：:To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control flexion of the fruit fly tibia. We find that leg motor neurons exhi...

journal_title：eLife

authors： Azevedo AW,Dickinson ES,Gurung P,Venkatasubramanian L,Mann RS,Tuthill JC

更新日期：2020-06-03 00:00:00

abstract：:Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for ful...

journal_title：eLife

authors： Li H,Wang H,Jing M,Zhu J,Guo B,Wang Y,Lin Y,Chen H,Kong L,Ma Z,Wang Y,Ye W,Dong S,Tyler B,Wang Y

更新日期：2018-10-22 00:00:00

abstract：:Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease that is a major cause of diarrhea-associated mortality in humans. Mice are highly resistant to Shigella and the lack of a tractable physiological model of shigellosis has impeded our understanding of this important human disease. Here,...

journal_title：eLife

authors： Mitchell PS,Roncaioli JL,Turcotte EA,Goers L,Chavez RA,Lee AY,Lesser CF,Rauch I,Vance RE

更新日期：2020-10-19 00:00:00

abstract：:Most evolutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and evolutionary optima. Nevertheless, it is often unclear what fitness actually is, and its meaning often depends on the context. Here we argue that fitness should not be a basal ingredient in verbal or mathemati...

journal_title：eLife

authors： Doebeli M,Ispolatov Y,Simon B

更新日期：2017-02-15 00:00:00

abstract：:Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western micr...

journal_title：eLife

authors： Di Rienzi SC,Jacobson J,Kennedy EA,Bell ME,Shi Q,Waters JL,Lawrence P,Brenna JT,Britton RA,Walter J,Ley RE

更新日期：2018-03-27 00:00:00

abstract：:The characteristics of goal-directed actions tend to resemble those of previously executed actions, but it is unclear whether such effects depend strictly on action history, or also reflect context-dependent processes related to predictive motor planning. Here we manipulated the time available to initiate movements af...

journal_title：eLife

authors： Marinovic W,Poh E,de Rugy A,Carroll TJ

更新日期：2017-10-23 00:00:00

abstract：:A strain of budding yeast that contains one large chromosome reveals how the telomere capping complex CST maintains linear but not circular chromosomes. ...

journal_title：eLife

authors： Nugent C,Sugimoto K

更新日期：2020-08-05 00:00:00

abstract：:Rats exhibit 'empathy' making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA ...

journal_title：eLife

authors： Lichtenberg NT,Lee B,Kashtelyan V,Chappa BS,Girma HT,Green EA,Kantor S,Lagowala DA,Myers MA,Potemri D,Pecukonis MG,Tesfay RT,Walters MS,Zhao AC,Blair RJR,Cheer JF,Roesch MR

更新日期：2018-11-28 00:00:00