Abstract:
:Presenting data on 50 of 55 patients with advanced TRK fusion-positive tumors, researchers reported that 76% of patients responded to the selective pan-TRK inhibitor larotrectinib, and 12% of patients experienced complete responses; 93% of responders remain on therapy. The targeted therapy was well tolerated, with just 13% of patients requiring a dose modification. None of the patients discontinued treatment due to adverse events.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
doi
10.1158/2159-8290.CD-NB2017-084subject
Has Abstractpub_date
2017-08-01 00:00:00pages
787issue
8eissn
2159-8274issn
2159-8290pii
2159-8290.CD-NB2017-084journal_volume
7pub_type
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