Abstract:
: Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the von Hippel-Lindau tumor suppressor gene (VHL), and the functional tumorigenic consequences of this loss have been used to develop therapies for advanced ccRCC, such as targeting activation of the HIF pathway. Yao and colleagues elucidate how VHL loss contributes to chromatin alteration at both gene promoters and enhancers/superenhancers, in both an HIF-dependent as well as independent manner, and how this may provide additional targets for therapeutic intervention in advanced ccRCC. Cancer Discov; 7(11); 1221-3. ©2017 AACRSee related article by Yao et al., p. 1284.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Ricketts CJ,Linehan WMdoi
10.1158/2159-8290.CD-17-0971subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1221-1223issue
11eissn
2159-8274issn
2159-8290pii
7/11/1221journal_volume
7pub_type
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