Abstract:
:A new study of all 32 cancer types in The Cancer Genome Atlas identifies genomic alterations that increase the activity of the PI3K/AKT/mTOR pathway. The study, which combines mutation data with measures of protein levels and phosphorylation status, suggests that mutations in IDH1, VHL, and STK11 promote activation of the pathway and may point to new drug targets.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
doi
10.1158/2159-8290.CD-NB2017-092subject
Has Abstractpub_date
2017-08-01 00:00:00pages
OF6issue
8eissn
2159-8274issn
2159-8290pii
2159-8290.CD-NB2017-092journal_volume
7pub_type
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