Can the Help Match the Hype? KRASG12C-Specific Inhibitors and Beyond.

Abstract:

:Hallin and colleagues demonstrate the preclinical activity of the KRASG12C-specific inhibitor MRTX849 in a series of in vitro and in vivo studies with supporting pilot clinical efficacy. Variable responsiveness despite effective KRASG12C inhibition highlights both the promise and potential need for combinatorial strategies to optimally target KRASG12C-driven cancers.See related article by Hallin et al., p. 54.

journal_name

Cancer Discov

journal_title

Cancer discovery

authors

Klempner SJ,Hata AN

doi

10.1158/2159-8290.CD-19-1255

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

20-22

issue

1

eissn

2159-8274

issn

2159-8290

pii

10/1/20

journal_volume

10

pub_type

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