Abstract:
:Hallin and colleagues demonstrate the preclinical activity of the KRASG12C-specific inhibitor MRTX849 in a series of in vitro and in vivo studies with supporting pilot clinical efficacy. Variable responsiveness despite effective KRASG12C inhibition highlights both the promise and potential need for combinatorial strategies to optimally target KRASG12C-driven cancers.See related article by Hallin et al., p. 54.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Klempner SJ,Hata ANdoi
10.1158/2159-8290.CD-19-1255subject
Has Abstractpub_date
2020-01-01 00:00:00pages
20-22issue
1eissn
2159-8274issn
2159-8290pii
10/1/20journal_volume
10pub_type
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