Abstract:
:Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter the stem cell state. This model contrasts with the notion that cancer stem cells are the direct products of neoplastically transformed normal tissue stem cells.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Chaffer CL,Weinberg RAdoi
10.1158/2159-8290.CD-14-0788subject
Has Abstractpub_date
2015-01-01 00:00:00pages
22-4issue
1eissn
2159-8274issn
2159-8290pii
5/1/22journal_volume
5pub_type
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