Abstract:
:Results from a phase III trial indicate that maintenance therapy with the PARP inhibitor niraparib is more effective than placebo in slowing the progression of recurrent platinum-sensitive ovarian cancer. Improved progression-free survival was seen regardless of the presence or absence of germline BRCA mutations, or of homologous recombination deficiency; however, patients who had these mutations or defective DNA repair did better.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
doi
10.1158/2159-8290.CD-NB2016-137subject
Has Abstractpub_date
2016-12-01 00:00:00pages
OF2issue
12eissn
2159-8274issn
2159-8290pii
2159-8290.CD-NB2016-137journal_volume
6pub_type
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