Abstract:
:Sen and colleagues have shown for the first time the clinical application of an oligonucleotide decoy targeting the oncogenic transcription factor STAT3 for the treatment of head and neck tumors. Intratumoral injection of decoy effectively reduced the activity of STAT3 as evidenced by a decrease in several of its transcriptional targets. However, its low bioavailability makes them unacceptable for systemic therapy. Cyclization of the STAT3 decoy markedly increased its half-life while preserving specificity and showed significant antitumor activity upon systemic delivery in preclinical models of head and neck cancer. These findings have broad therapeutic implications for the treatment of many malignancies.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Koppikar P,Bromberg Jdoi
10.1158/2159-8290.CD-12-0310subject
Has Abstractpub_date
2012-08-01 00:00:00pages
670-2issue
8eissn
2159-8274issn
2159-8290pii
2/8/670journal_volume
2pub_type
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