Abstract:
:Although BRAF-MEK inhibition can enhance the immune recognition of melanoma cells, the mechanisms that underlie this remain poorly defined. In this issue of Cancer Discovery, Erkes and colleagues present new data showing that BRAF-MEK inhibition activates pyroptosis in melanoma cells through gasdermin E cleavage, leading to T-cell infiltration and improved therapy responses in vivo.See related article by Erkes et al., p. 254.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Smalley KSMdoi
10.1158/2159-8290.CD-19-1441subject
Has Abstractpub_date
2020-02-01 00:00:00pages
176-178issue
2eissn
2159-8274issn
2159-8290pii
10/2/176journal_volume
10pub_type
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