Abstract:
:Researchers have developed an antibody-drug conjugate with the potential to treat neuroblastoma. The agent targets ALK, which is found on neuroblastoma cells but not healthy cells, delivering a drug that causes DNA cross-links. Researchers have found that the antibody-drug conjugate kills ALK-expressing cells in vitro and increases survival in mouse models of neuroblastoma.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
doi
10.1158/2159-8290.CD-NB2019-052subject
Has Abstractpub_date
2019-06-01 00:00:00pages
OF2issue
6eissn
2159-8274issn
2159-8290pii
2159-8290.CD-NB2019-052journal_volume
9pub_type
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