Abstract:
:Even in diffuse large B-cell lymphoma (DLBCL), a cancer of professional antigen-presenting cells, response rates to immune checkpoint blockade therapy have been limited. One reason for DLBCL immune evasion is epigenetic repression instead of activation of the antigen-presenting MHC-a dissection of mechanisms underlying this repression suggests an opening for restoring B-cell maturation and, along the way, MHC expression as a novel modality of cytoreducing DLBCL and simultaneously augmenting possibilities for immunotherapy.See related article by Ennishi et al., p. 546.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Velcheti V,Wong KK,Saunthararajah Ydoi
10.1158/2159-8290.CD-19-0090subject
Has Abstractpub_date
2019-04-01 00:00:00pages
472-475issue
4eissn
2159-8274issn
2159-8290pii
9/4/472journal_volume
9pub_type
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