Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice.

abstract：:Cyanobacteria are photosynthetic prokaryotes that make major contributions to the production of the oxygen in the Earth atmosphere. The photosynthetic machinery in cyanobacterial cells is housed in flattened membrane structures called thylakoids. The structural organization of cyanobacterial cells and the arrangement ...

journal_title：Scientific reports

authors： Stingaciu LR,O'Neill H,Liberton M,Urban VS,Pakrasi HB,Ohl M

更新日期：2016-01-21 00:00:00

abstract：:Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allo...

journal_title：Scientific reports

authors： Ma T,Peng Y,Huang W,Ding J

更新日期：2017-01-18 00:00:00

abstract：:Bovine TB (bTB) is endemic in Irish cattle and has eluded eradication despite considerable expenditure, amid debate over the relative roles of badgers and cattle in disease transmission. Using a comprehensive dataset from Northern Ireland (>10,000 km(2); 29,513 cattle herds), we investigated interactions between host ...

journal_title：Scientific reports

authors： Wright DM,Reid N,Ian Montgomery W,Allen AR,Skuce RA,Kao RR

更新日期：2015-08-17 00:00:00

abstract：:We present a concept and prototype of a memory element based on current driven magneto-impedance (MI) effect that stores the binary data (0, 1) as the orientation of the magnetization. The magnetization orientation in the surface layer with tilted anisotropy easy axis can be switched controllably between two stable st...

journal_title：Scientific reports

authors： Ipatov M,Zhukova V,Zhukov A,Gonzalez J

更新日期：2016-10-26 00:00:00

abstract：:Zinc oxy-selenide Zn(O,Se) is a novel material, that can replace the toxic CdS buffer layer in thin film solar cells and other optoelectronic devices. In this paper a systematic study of the structural, optical and electrical properties of Zn(O,Se) layers, grown by pulsed laser deposition under 50 mTorr of nitrogen ba...

journal_title：Scientific reports

authors： Abdalla A,Bereznev S,Spalatu N,Volobujeva O,Sleptsuk N,Danilson M

更新日期：2019-11-25 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such as Hepatitis C virus (HCV) and Dengue virus (DENV). Cell-free flaviviridae virions poorly stimulate pDCs to produce IFN. By contrast,...

journal_title：Scientific reports

authors： Sinigaglia L,Gracias S,Décembre E,Fritz M,Bruni D,Smith N,Herbeuval JP,Martin A,Dreux M,Tangy F,Jouvenet N

更新日期：2018-07-18 00:00:00

abstract：:The subjective experience of thermal pain follows the detection and encoding of noxious stimuli by primary afferent neurons called nociceptors. However, nociceptor morphology has been hard to access and the mechanisms of signal transduction remain unresolved. In order to understand how heat transducers in nociceptors ...

journal_title：Scientific reports

authors： Dezhdar T,Moshourab RA,Fründ I,Lewin GR,Schmuker M

更新日期：2015-12-07 00:00:00

abstract：:The role of changes in dopamine neuronal activity during the development of symptoms in affective disorders remains controversial. Here, we show that inactivation of NMDA receptors on dopaminergic neurons in adult mice led to the development of affective disorder-like symptoms. The loss of NMDA receptors altered activ...

journal_title：Scientific reports

authors： Jastrzębska K,Walczak M,Cieślak PE,Szumiec Ł,Turbasa M,Engblom D,Błasiak T,Parkitna JR

更新日期：2016-11-17 00:00:00

abstract：:Decline in episodic memory performance usually causes the first clinical symptoms of Alzheimer's disease. At present, Alzheimer's disease can only be diagnosed at a very late stage when neurodegeneration and cognitive impairment is already irreversible. New early disease markers are needed for earlier and more efficie...

journal_title：Scientific reports

authors： Konki M,Lindgren N,Kyläniemi M,Venho R,Laajala E,Ghimire B,Lahesmaa R,Kaprio J,Rinne JO,Lund RJ

更新日期：2020-08-25 00:00:00

abstract：:Circulating compounds such as drugs and nutritional components might adhere to the oxygenator fibers and tubing during ECMO support. This study evaluated the amount of nutritional supplements adsorbed to the ECMO circuit under controlled ex vivo conditions. Six identical ECMO circuits were primed with fresh human whol...

journal_title：Scientific reports

authors： Lindberg BR,Videm V,Dahl T,Sørensen G,Fiane AE,Thiara AS

更新日期：2020-11-06 00:00:00

abstract：:The presence of well-vascularised, endosteal bone in the medullary region of long bones of nonavian dinosaurs has been invoked as being homologous to medullary bone, a specialised bone tissue formed during ovulation in birds. However, similar bone tissues can result as a pathological response in modern birds and in no...

journal_title：Scientific reports

authors： Chinsamy A,Cerda I,Powell J

更新日期：2016-04-26 00:00:00

abstract：:The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and spec...

journal_title：Scientific reports

authors： Boland MR,Kraus MS,Dziuk E,Gelzer AR

更新日期：2018-05-17 00:00:00

abstract：:Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...

journal_title：Scientific reports

authors： Persson ME,Wright D,Roth LS,Batakis P,Jensen P

更新日期：2016-09-29 00:00:00

abstract：:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute inflammatory vesiculobullous reactions of the skin and mucous membranes. These severe cutaneous drug reactions are known to be caused by inciting drugs and infectious agents. Previously, we have reported the association of H...

journal_title：Scientific reports

authors： Nakatani K,Ueta M,Khor SS,Hitomi Y,Okudaira Y,Masuya A,Wada Y,Sotozono C,Kinoshita S,Inoko H,Tokunaga K

更新日期：2019-11-07 00:00:00

abstract：:In this study, nanowires/nanowalls were generated on a silicon wafer through a chemical etching method. Octadecyltrichlorosilane (OTS) was deposited onto the nanowire/nanowall surfaces to alter their hydrophobicity. The hydrophobic characteristics of the surfaces were further modified via a 1.5-μm-thick layer of n-oct...

journal_title：Scientific reports

authors： Yilbas BS,Salhi B,Yousaf MR,Al-Sulaiman F,Ali H,Al-Aqeeli N

更新日期：2016-12-09 00:00:00

abstract：:We investigated the effect of a new Rho kinase inhibitor, SB772077B (SB77) on aqueous outflow facility (OF) in human eyes using human organ-cultured anterior segment (HOCAS). IOP was monitored for 24 h post-treatment with either SB77 (0.1/10/50 µM) or vehicle after a stable baseline pressure. The hydrodynamic pattern ...

journal_title：Scientific reports

authors： Ashwinbalaji S,Senthilkumari S,Gowripriya C,Krishnadas S,Gabelt BAT,Kaufman PL,Muthukkaruppan V

更新日期：2018-10-19 00:00:00

abstract：:Genes with similar roles in the cell cluster on chromosomes, thus benefiting from coordinated regulation. This allows gene function to be inferred by transferring annotations from genomic neighbors, following the guilt-by-association principle. We performed a systematic search for co-occurrence of >1000 gene functions...

journal_title：Scientific reports

authors： Mihelčić M,Šmuc T,Supek F

更新日期：2019-12-20 00:00:00

abstract：:Porphyry systems supply most copper and significant gold to our economy. Recent studies indicate that they are frequently associated with high Sr/Y magmatic rocks, but the meaning of this association remains elusive. Understanding the association between high Sr/Y magmatic rocks and porphyry-type deposits is essential...

journal_title：Scientific reports

authors： Chiaradia M,Ulianov A,Kouzmanov K,Beate B

更新日期：2012-01-01 00:00:00

abstract：:Triterpenic acids (TAs), a large group of natural compounds with diverse biological activity, are produced by several plant taxa. Betulinic, oleanolic, and ursolic acids are the most medicinally important TAs and are mainly found in plants of the mint family. Metabolic engineering is strongly dependent on identifying ...

journal_title：Scientific reports

authors： Aminfar Z,Rabiei B,Tohidfar M,Mirjalili MH

更新日期：2019-11-01 00:00:00

abstract：:Over the last decades, great strides were made in the development of novel implants for the treatment of bone defects. The increasing versatility and complexity of these implant designs request for concurrent advances in means to assess in vivo the course of induced bone formation in preclinical models. Since its disc...

journal_title：Scientific reports

authors： Lienemann PS,Metzger S,Kiveliö AS,Blanc A,Papageorgiou P,Astolfo A,Pinzer BR,Cinelli P,Weber FE,Schibli R,Béhé M,Ehrbar M

更新日期：2015-05-19 00:00:00

abstract：:In our previous study, a liver-targeting peptide CSP I-plus modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed and showed potent antiangiogenic capability and could specifically bind to human hepatocellular carcinoma cells to make a direct inhibition in vitro. In this study, the bi...

journal_title：Scientific reports

authors： Yan M,Dongmei B,Jingjing Z,Xiaobao J,Jie W,Yan W,Jiayong Z

更新日期：2017-10-26 00:00:00

abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...

journal_title：Scientific reports

authors： Polini A,Pagliara S,Camposeo A,Cingolani R,Wang X,Schröder HC,Müller WE,Pisignano D

更新日期：2012-01-01 00:00:00

abstract：:Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult CKD patients newly...

journal_title：Scientific reports

authors： Peng YL,Tain YL,Lee CT,Yang YH,Huang YB,Wen YH,Hsu CN

更新日期：2020-07-01 00:00:00

abstract：:Exposure to stress during early life affects subsequent behaviors and increases the vulnerability to adult pathologies, a phenomenon that has been well documented in humans and rodents. In this study, we introduce a chronic unpredictable stress protocol adapted to young zebrafish, which is an increasingly popular vert...

journal_title：Scientific reports

authors： Golla A,Østby H,Kermen F

更新日期：2020-06-25 00:00:00

abstract：:Mesenchymal stromal cells (MSC) are used in cell therapies, however cellular senescence increases heterogeneity of cell populations and leads to uncertainty in therapies' outcomes. The determination of cellular senescence is time consuming and logistically intensive. Here, we propose the use of endogenous autofluoresc...

journal_title：Scientific reports

authors： Bertolo A,Baur M,Guerrero J,Pötzel T,Stoyanov J

更新日期：2019-02-14 00:00:00

abstract：:A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50% were annotated. The cellular and functional distribution of the EST clones indicated high ...

journal_title：Scientific reports

authors： Huang W,Zhang Y,Chen Y,Wang Y,Yuan W,Zhang N,Lam TJ,Gong Z,Yang D,Lin Z

更新日期：2017-10-17 00:00:00

abstract：:We propose a homomorphic search protocol based on quantum homomorphic encryption, in which a client Alice with limited quantum ability can give her encrypted data to a powerful but untrusted quantum server and let the server search for her without decryption. By outsourcing the interactive key-update process to a trus...

journal_title：Scientific reports

authors： Zhou Q,Lu S,Cui Y,Li L,Sun J

更新日期：2020-03-20 00:00:00

abstract：:Chemical separation has great importance in industrial applications. Separation of xylene isomers still prevails to be one of the most important challenges in chemical industry, due to the large amount of commercial use of p-xylene in the production of beverage bottles, fibers and films. A novel Zn(II)-based dynamic c...

journal_title：Scientific reports

authors： Mukherjee S,Joarder B,Manna B,Desai AV,Chaudhari AK,Ghosh SK

更新日期：2014-07-21 00:00:00

abstract：:Numerous essential metal elements (EMEs) are necessary to maintain the proper function of human body. In this case-control study, we investigated the associations of 11 EMEs [Calcium (Ca), potassium (K), magnesium (Mg), sodium (Na), manganese (Mn), selenium (Se), cobalt (Co), Molybdenum (Mo), copper (Cu), zinc (Zn), a...

journal_title：Scientific reports

authors： Ma J,Yan L,Guo T,Yang S,Liu Y,Xie Q,Ni D,Wang J

更新日期：2020-07-03 00:00:00

abstract：:Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...

journal_title：Scientific reports

authors： Liu Y,Broberg MCG,Watanabe M,Rollins AM,Jenkins MW

更新日期：2019-01-29 00:00:00