[Combination of hemodialysis and hemofiltration in severe caffeine intoxication].

Abstract:

:A 21-year-old man ingested 75g of pure caffeine, in an attempt to commit suicide. This represents 7.5 times the minimal lethal dose. Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet. Mechanisms of action are dose-dependent. When caffeine overdosing occurs, neurologic, cardiovascular and renal systems are mainly affected. Severe intoxication can be fatal. No antidote is available and treatment is purely symptomatic. Hemoperfusion has previously been carried out in the 1990's to treat patients with caffeine intoxication. Since 2009, hemodialysis and hemofiltration have proposed as well. Our patient was successfully treated with a combination of hemodiafiltration, intermittent and then continuous.

journal_name

Nephrol Ther

authors

Colin-Benoit E,Friolet R,Rusca M,Teta D,Gobin N

doi

10.1016/j.nephro.2016.10.005

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

183-187

issue

3

eissn

1769-7255

issn

1872-9177

pii

S1769-7255(17)30109-8

journal_volume

13

pub_type

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