Abstract：
:IgA nephropathy is the primitive glomerulonephritis the most frequently encountered worldwide. In about one case out of three, it is responsible for the progression from progressive renal failure to end-stage renal failure. The pathophysiological mechanisms of this disease which is mediated by immune complexes remain unclear. The presentation, clinical progression and optical microscope aspect of the renal biopsy may widely vary, making any histological classification very difficult. Most therapeutic studies include the patients only on clinical criteria of severity. The only consensual management is that of patients with a nephropathy and mild glomerular lesions and a nephritic syndrome, or with an extracapillar glomerulonephritis and a rapidly progressive renal failure; corticoids are indicated in former cases while corticoids must be combined with immunosuppressive agents in the latter ones. Corticotherapy may be considered in patients with a proteinuria higher than 1g/day without renal failure. In any patient with primitive IgA nephropathy, the overall management used for chronic glomerulopathy must be initiated, including, in case of arterial hypertension or proteinuria, the renin-angiotensin system blockade.
journal_name
Nephrol Therjournal_title
Nephrologie & therapeutiqueauthors
Pillebout E,Nochy Ddoi
10.1016/j.nephro.2010.03.007subject
Has Abstractpub_date
2010-11-01 00:00:00pages
545-57issue
6eissn
1769-7255issn
1872-9177pii
S1769-7255(10)00055-6journal_volume
6pub_type
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journal_title：Nephrologie & therapeutique
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journal_title：Nephrologie & therapeutique
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journal_title：Nephrologie & therapeutique
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journal_title：Nephrologie & therapeutique
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pub_type： 杂志文章
doi：10.1016/j.nephro.2005.12.004
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