Abstract:
:Post-transplantation lymphoproliferative disorder (PTLD) is a well-know complication after organ transplantation. We report a case of a patient who developed an extramedullary plasmacytoma-like PTLD around his transplanted kidney treated with standard multiple myeloma chemotherapy. Three years after benefiting of a deceased donor kidney transplant for an end stage kidney disease secondary to nephroangiosclerosis, our patient developed an extra-medullary plasmacytoma confined to the transplant compartment. The transplant function was unaltered, and due to the absence of reduction of the lesion after immunosuppression reduction, a chemotherapy by bortezomib-cyclophosphamide-dexamethasone (VCD) known to be efficient in multiple myeloma was initiated. After 6 cycles, positron emission tomography (PET) scan showed complete metabolic remission confirming the biological exams. This case report suggests that a chemotherapy such as VCD can efficiently treat plasmacytoma-like PTLD allowing graft survival. Therefore, transplant removal may not be mandatory as the best second line treatment after unsuccessfulness reduction of immunosuppression.
journal_name
Nephrol Therjournal_title
Nephrologie & therapeutiqueauthors
Thibaud V,Rivalan J,Llamas F,Cherel M,Decaux O,Vigneau Cdoi
10.1016/j.nephro.2018.07.404subject
Has Abstractpub_date
2018-12-01 00:00:00pages
544-547issue
7eissn
1769-7255issn
1872-9177pii
S1769-7255(18)30563-7journal_volume
14pub_type
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journal_title:Nephrologie & therapeutique
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