Abstract：
:The overall risk of cancer in the kidney transplant patient is three to five times higher than the risk in the general population, and the risk of cutaneous epitheliomas, the most frequent, is multiplied by 100. There are many causes of posttransplantation cancer involving modifications in the immunosurveillance of neoplastic cells, viral reactivation or an increase in viral infections, genetic or acquired risks, but also immunosuppressors. Azathioprine and anticalcineurins in particular are associated with an increase in cancer risk. This is why at-risk patients should be monitored closely before and after transplantation. During the pretransplantation period, the risk factors present should be eradicated and the patient screened for cancers. In the posttransplantation period, prevention is indispensable, with regular screening for cancer, sun protection, and induction treatment adapted to the risk present. In transplantation patients who have developed cancer, immunosuppression can, however, be preserved using proliferation signal inhibitors, which present useful anti-tumor activity at doses that are effective for immunosuppression. Effective treatment of the cancer can now be expected without systematically losing the graft after interrupting the transplantation treatment.
journal_name
Nephrol Therjournal_title
Nephrologie & therapeutiqueauthors
Moal MCdoi
10.1016/S1769-7255(08)74238-Xsubject
Has Abstractpub_date
2008-10-01 00:00:00pages
S214-7eissn
1769-7255issn
1872-9177pii
S1769-7255(08)74238-Xjournal_volume
4 Suppl 3pub_type
杂志文章,评审abstract：:In 2006, 6,509 patients with end-stage renal disease living in 16 regions covering 48(M) inhabitants (79% of the French population), started renal replacement therapy (dialysis or preemptive graft): median age was 71 years; 3% had a preemptive graft. The overall crude annual incidence rate of renal replacement therapy...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:Primary hyperoxalurias are rare recessive inherited inborn errors of glyoxylate metabolism. They are responsible for progressive renal involvement, which further lead to systemic oxalate deposition, which can even occur in infants. Primary hyperoxaluria type 1 is the most common form in Europe and is due to alanine-gl...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2011.03.004
更新日期：2011-07-01 00:00:00
abstract：:Psychological support before kidney donation is advocated by all authors, but not systematically proposed by all transplantation centers. An analysis of the literature shows that there are many positive aspects to organ donation including improved self-esteem and quality of life. But many secondary psychological effec...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2007.07.010
更新日期：2008-02-01 00:00:00
abstract：:Dialysis-related constraints encourage questioning about discontinuation of treatment. In France, the 04/22/2005 law, related to patients' rights and end-of-life issues, defines bounds to treatment withdrawal, authorizing it in specific conditions, to avoid foolish obstinacy. Shortly before the publication of this law...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2007.03.004
更新日期：2007-07-01 00:00:00
abstract：:Recombinant human erythropoietin (rHuEPO) has transformed the management chronic renal failure (CKD) and considerably improved the outcome of patients on regular chronic dialysis. However, a significant number of patients fail to respond to high of Erythropoiesis-stimulating agents (ESAs) and several causes of inadequ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Clinical nephrology in the european french-speaking countries made great strides just after the 2nd World War. The "Société de Pathologie Rénale" was founded and assembles French, Belgian and Swiss nephrologists. The first studies were physiopathological and bore on acute uremia and the associated hydromineral disorde...
journal_title：Nephrologie & therapeutique
pub_type： 历史文章,杂志文章
doi：10.1016/j.nephro.2009.01.005
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:To investigate the role of neutrophil gelatinase-associated lipocalin in the evaluation of renal function, nutrition, anemia and inflammation in patients with chronic kidney diseases. MATERIALS AND METHODS:A total of 302 patients with chronic kidney diseases were selected, and their clinical data, blood neut...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2020.10.006
更新日期：2021-01-16 00:00:00
abstract：:A 21-year-old man ingested 75g of pure caffeine, in an attempt to commit suicide. This represents 7.5 times the minimal lethal dose. Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has be...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2016.10.005
更新日期：2017-05-01 00:00:00
abstract：:The source of living kidney donors in the general population remains underused. The present study aims at assessing the prevalence and the characteristics of potential living kidney donors in Ivory Coast in a view of a project of kidney transplantation in French Black Africa. A survey was undertaken in Abidjan from 30...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2006.12.003
更新日期：2007-12-01 00:00:00
abstract：:Focal segmental glomerulosclerosis is a common glomerular histological lesion, which is usually characterised by non-nephrotic range proteinuria or nephrotic syndrome. It may be idiopathic or occurs secondarily to drugs, diabetes, obesity or HIV nephropathy and other infections. Dasatinib, a tyrosine kinase inhibitor ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2020.09.007
更新日期：2021-01-08 00:00:00
abstract：:End-stage renal disease has an important impact on the patients' daily life, which can be measured by quality of life questionnaires. The objective of this work was to adapt the Kidney Disease Quality of Life questionnaire (KDQoL) into French and to determine its basic psychometric properties, i.e. validity and reliab...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2007.05.005
更新日期：2007-10-01 00:00:00
abstract：:Surgical removal of a hemodialysis access after thrombosis is generally not performed as it remains clinically well tolerated. However, it may be the source of distal embolization. We report the case of a 43-year-old patient, kidney recipient, who presented with digital ischemia of the right hand. He had a forearm art...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2009.12.002
更新日期：2010-04-01 00:00:00
abstract：:Diabetic nephropathy is a frequent complication in type 2 diabetic. Patients with diabetic nephropathy have a characteristic dyslipidemia profile associated increased concentrations of triglycerides, reduced levels of HDL cholesterol, and qualitative abnormalities of LDL. The dyslipidemia management in patients with d...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:The recent history of French and Brazilian medicine goes back to the first decades of the xixth century. As regards nephrology, the first links were established starting in the 1950s of the xxth century. Over the past 60 years, the scientific production of the Franco-Brazilian school of nephrology totalized more than ...
journal_title：Nephrologie & therapeutique
pub_type： 历史文章,杂志文章
doi：10.1016/j.nephro.2012.05.004
更新日期：2012-12-01 00:00:00
abstract：:The understanding of water traffic through biological membranes has tremendously progressed with the discovery of the aquaporins. Aquaporins water channels inserted in lipid bilayer drive specific, regulated, water flux under osmotic gradient. Some of them, the aquaglycéroporines, are permeated by urea, glycerol and o...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2008.03.009
更新日期：2008-12-01 00:00:00
abstract：:High blood pressure during renal disease is highly prevalent and an important risk factor for cardiovascular disease and renal progression. Its optimal management is therefore necessary to improve the prognosis of patients. Several trials concerning the blood pressure target in patients with chronic non-diabetic kidne...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2018.01.001
更新日期：2018-11-01 00:00:00
abstract：AIM:Post-streptococcal glomerulonephritis (PSGN) is a frequent cause of acute nephritis in children. This study aimed to describe the epidemiology, clinical characteristics and outcomes of PSGN and look for predictor's factors of severity. METHODS:A 12-year retrospective review of case notes and laboratory data was co...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2018.04.001
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:The treatment of secondary hyperparathyroidism (SHPT) in dialysis patients has changed with the introduction of cinacalcet (CC), which represents a medical alternative to surgical parathyroidectomy (PTX). The aim of our study is to prospectively assess the tolerance and efficacy of CC in patients, treated ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2009.12.004
更新日期：2010-04-01 00:00:00
abstract：:Salt consumption has substantially increased these last years in our modern societies and far exceeds our needs. It has a great impact on cardiovascular and renal disease and represents a major issue in public health. The present work is a review of observational and interventional studies exploring the relationship b...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2018.02.002
更新日期：2018-04-01 00:00:00
abstract：:Perioperative period is very likely to lead to acute renal failure because of anesthesia (general or perimedullary) and/or surgery which can cause acute kidney injury. Characterization of acute renal failure is based on serum creatinine level which is imprecise during and following surgery. Studies are based on variou...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2013.11.007
更新日期：2014-04-01 00:00:00
abstract：:Cytomegalovirus infection in kidney transplantation is associated with increased morbidity and mortality through direct and indirect effects. International guidelines had been recently updated, focusing on diagnostic, prevention strategies and curative treatment. Cytomegalovirus-specific immune response plays also an ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2015.03.005
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:The FIND-CKD study has validated the use of ferric carboxymaltose (FCM) injection with a target of ferritin level between 400 and 600ng/mL to treat iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD) patients. In order to assess this strategy in clinical practice, we constitute...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2018.10.006
更新日期：2019-04-01 00:00:00
abstract：:The financial advantage of the oral treatments of iron is minimised by their low bioavailibility (10 to 20%) and the fact that instructions for oral treatments are often badly followed by the patient (eg: tablets taken too far away from meals inducing frequent digestive problems). In France, since Maltofer (hydroxic f...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
abstract：:BK virus is near ubiquitous, with a seroprevalence of around 80% in the general population. Subsequent to an asymptomatic primary infection, BK virus then remains dormant in healthy subjects. Reactivation occurs in immunocompromised people. BKv is pathogenic mainly among patients who have received a kidney transplant,...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2015.11.003
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION:Optimal drug treatment may slow down the progression of chronic kidney disease (CKD) and reduce the associated complications. We conducted a study to assess the drug treatment of inpatients with CKD at their discharge. METHODS:We retrospectively collected patient data from the electronic medical record of...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2014.08.004
更新日期：2015-02-01 00:00:00
abstract：:Cytomegalovirus is common in adult recipients (prevalence of 40-90%). Children are typically seronegative but immunosuppression may prone to primary-infection or viral reactivation, with potentially severe consequences. CMV infection incidence in pediatric kidney transplant recipients has seldom been investigated. The...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2018.04.003
更新日期：2019-03-01 00:00:00
abstract：:Studies at the population level must take into account the effect of social insecurity and socioeconomic inequalities on the patient outcomes. Socioeconomic inequalities depend on many determinants that are socially determined. In renal transplantation, these social determinants are not registered in the databases. Th...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2017.04.003
更新日期：2018-04-01 00:00:00
abstract：:Conventional peritoneal dialysis solutions are mostly bioincompatible in relationship with a low pH, a high glucose and glucose degradation products (GDP) concentrations inducing anatomical and functional peritoneal membrane alterations. Use of icodextrin solution instead of glucose hypertonic solution preserves perit...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/S1769-7255(09)74560-2
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Due to technical requirements and cost, hemodiafiltration (HDF) is not widely used in pediatrics. We have been using online HDF (oHDF) since 2009 and we observed low parathyroid hormone (PTH) levels despite the accurate management of CKD-MBD. METHODS:We reviewed the medical charts and parameters of mineral ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2013.09.003
更新日期：2014-02-01 00:00:00
abstract：:The dramatic occurrence, during haemodialysis sessions, of hemodynamic and cerebral symptoms in a 53-year-old haemodialysed woman with a history of aortocoronary bypass leads to discovery and treatment by percutaneous angioplasty and stenting of a significant stenosis of proximal subclavian artery, ipsilateral to the ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2009.06.002
更新日期：2009-12-01 00:00:00
