Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention.

abstract：:Chemoattractant gradients are usually considered in terms of sources and sinks that are independent of the chemotactic cell. However, recent interest has focused on 'self-generated' gradients, in which cell populations create their own local gradients as they move. Here, we consider the interplay between chemoattracta...

journal_title：Interface focus

authors： Mackenzie JA,Nolan M,Insall RH

更新日期：2016-10-06 00:00:00

abstract：:The emergence of life on Earth (and elsewhere) must have occurred in a milieu that is far from equilibrium, such as at alkaline hydrothermal vents that would have harboured built-in gradients in temperature, redox potential and pH along with precipitated iron-bearing minerals capable of separating these gradients, con...

journal_title：Interface focus

authors： Ponce A

更新日期：2019-12-06 00:00:00

abstract：:Biofuels have gained increasing attention as an alternative to fossil fuels for several reasons, one of which is their potential to reduce the greenhouse gas (GHG) emissions from the transportation sector. Recent studies have questioned the validity of claims about the potential of biofuels to reduce GHG emissions rel...

journal_title：Interface focus

authors： Khanna M,Crago CL,Black M

更新日期：2011-04-06 00:00:00

abstract：:Moving from homogeneous water-splitting photocatalytic systems to photoelectrochemical devices requires the preparation and evaluation of novel p-type transparent conductive photoelectrode substrates. We report here on the sensitization of polystyrene-block-poly-(2-vinylpyridine) (PS-b-P2VP) diblock copolymer-template...

journal_title：Interface focus

authors： Massin J,Bräutigam M,Kaeffer N,Queyriaux N,Field MJ,Schacher FH,Popp J,Chavarot-Kerlidou M,Dietzek B,Artero V

更新日期：2015-06-06 00:00:00

abstract：:We present the development of a tool, which provides users with the ability to visualize and interact with a comprehensive description of a multi-scale model of the renal nephron. A one-dimensional anatomical model of the nephron has been created and is used for visualization and modelling of tubule transport in vario...

journal_title：Interface focus

authors： Nickerson DP,Terkildsen JR,Hamilton KL,Hunter PJ

更新日期：2011-06-06 00:00:00

abstract：:How did people in the sixteenth and seventeenth centuries account for sleep loss? This article answers this question through an in-depth analysis of the life-writings of six early modern women and men that suffered from periodic or persistent episodes of sleep loss. It focuses on the ways in which these health crises ...

journal_title：Interface focus

authors： Handley S

更新日期：2020-06-06 00:00:00

abstract：:Multi-site enzymes, defined as where multiple substrate molecules can bind simultaneously to the same enzyme molecule, play a key role in a number of biological networks, with the Escherichia coli protease ClpXP a well-studied example. These enzymes can form a low latency 'waiting line' of substrate to the enzyme's ca...

journal_title：Interface focus

authors： Hochendoner P,Ogle C,Mather WH

更新日期：2014-06-06 00:00:00

abstract：:The morphology of the toe epithelium of the rock frog, Staurois parvus (Family Ranidae), was investigated using a variety of microscopical techniques. The toe pad epithelium is stratified (four to five cell layers), the apical parts of the cells of the outermost layer being separated by fluid-filled channels. The surf...

journal_title：Interface focus

authors： Drotlef DM,Appel E,Peisker H,Dening K,Del Campo A,Gorb SN,Barnes WJ

更新日期：2015-02-06 00:00:00

abstract：:Biominerals are typically indispensable structures for their host organism in which they serve varying functions, such as mechanical support and protection, mineral storage, detoxification site, or as a sensor or optical guide. In this perspective article, we highlight the occurrence of both structural diversity and u...

journal_title：Interface focus

authors： Harris J,Böhm CF,Wolf SE

更新日期：2017-08-06 00:00:00

abstract：:Biofuels production from microalgae attracts much attention but remains an unproven technology. We explore routes to enhance production through modifications to a range of generic microalgal physiological characteristics. Our analysis shows that biofuels production may be enhanced ca fivefold through genetic modificat...

journal_title：Interface focus

authors： Flynn KJ,Mitra A,Greenwell HC,Sui J

更新日期：2013-02-06 00:00:00

abstract：:A novel class of ultra-thin fibres, which affect microbial growth, were explored. The microbial properties of poly(methyl methacrylate) fibres containing 2, 4 and 8 wt% of graphene nanoplatelets (GNPs) were studied. GNPs were dispersed in a polymeric solution and processed using pressurized gyration. Electron microsco...

journal_title：Interface focus

authors： Matharu RK,Porwal H,Ciric L,Edirisinghe M

更新日期：2018-06-06 00:00:00

abstract：:We construct the components for a family of computational models of the electrophysiology of the human foetal heart from 60 days gestational age (DGA) to full term. This requires both cell excitation models that reconstruct the myocyte action potentials, and datasets of cardiac geometry and architecture. Fast low-angl...

journal_title：Interface focus

authors： Pervolaraki E,Anderson RA,Benson AP,Hayes-Gill B,Holden AV,Moore BJ,Paley MN,Zhang H

更新日期：2013-04-06 00:00:00

abstract：:[This corrects the article DOI: 10.1098/rsfs.2017.0015.]. ...

journal_title：Interface focus

authors： Müller GB

更新日期：2017-12-06 00:00:00

abstract：:Nanoparticles do not exist in thermodynamical equilibrium because of high surface free energy, thus they have only kinetic stability. Spontaneous changes can be delayed by designed surface coating. In biomedical applications, superparamagnetic iron oxide nanoparticles (SPIONs) require an optimized coating in order to ...

journal_title：Interface focus

authors： Tombácz E,Farkas K,Földesi I,Szekeres M,Illés E,Tóth IY,Nesztor D,Szabó T

更新日期：2016-12-06 00:00:00

abstract：:Material deformation and pitting from cavitation bubble collapse is investigated using fluid and material dynamics and their interaction. In the fluid, a novel hybrid approach, which links a boundary element method and a compressible finite difference method, is used to capture non-spherical bubble dynamics and result...

journal_title：Interface focus

authors： Chahine GL,Hsiao CT

更新日期：2015-10-06 00:00:00

abstract：:There is a growing need for patient-specific and holistic modelling of the heart to support comprehensive disease assessment and intervention planning as well as prediction of therapeutic outcomes. We propose a patient-specific model of the whole human heart, which integrates morphology, dynamics and haemodynamic para...

journal_title：Interface focus

authors： Mihalef V,Ionasec RI,Sharma P,Georgescu B,Voigt I,Suehling M,Comaniciu D

更新日期：2011-06-06 00:00:00

abstract：:A computational model of the outer hair cell (OHC) of the mammalian cochlea is presented. It addresses the way in which movement of ions controls the cell shape and regulates pH. The model takes into account the possible chloride-bicarbonate exchange function of prestin, a protein highly expressed in the plasma membra...

journal_title：Interface focus

authors： West T,Ashmore J

更新日期：2014-12-06 00:00:00

abstract：:The bulk mechanical properties of tissues are highly tuned to the physiological loads they experience and reflect the hierarchical structure and mechanical properties of their constituent parts. A thorough understanding of the processes involved in tissue adaptation is required to develop multi-scale computational mod...

journal_title：Interface focus

authors： Susilo ME,Paten JA,Sander EA,Nguyen TD,Ruberti JW

更新日期：2016-02-06 00:00:00

abstract：:In this paper, we show that solutions to ordinary differential equations describing the large-population limits of Markovian stochastic epidemic models can be interpreted as survival or cumulative hazard functions when analysing data on individuals sampled from the population. We refer to the individual-level survival...

journal_title：Interface focus

authors： KhudaBukhsh WR,Choi B,Kenah E,Rempała GA

更新日期：2020-02-06 00:00:00

abstract：:Periodontitis is a polymicrobial, biofilm-caused, inflammatory disease affecting the tooth-supporting tissues. It is not only the leading cause of tooth loss worldwide, but can also impact systemic health. The development of effective treatment strategies is hampered by the complicated disease pathogenesis which is be...

journal_title：Interface focus

authors： Bloch S,Tomek MB,Friedrich V,Messner P,Schäffer C

更新日期：2019-04-06 00:00:00

abstract：:The ability of the baby to receive nutrients and oxygen in utero depends on the healthy development of the placenta. For maternal blood to adequately perfuse the placenta, it dramatically alters the arteries in the uterus that supply it with nutrient-rich blood right from the start of pregnancy. Placental cells (troph...

journal_title：Interface focus

authors： Saghian R,Bogle G,James JL,Clark AR

更新日期：2019-10-06 00:00:00

abstract：:Silica carriers equipped with molecular and supramolecular pH-sensitive nanovalves were designed by combination of sol-gel synthesis and selective postsynthetic modification. Mesoporous structure of synthesized materials was characterized by low-temperature nitrogen adsorption-desorption, small-angle X-ray diffraction...

journal_title：Interface focus

authors： Roik NV,Belyakova LA

更新日期：2016-12-06 00:00:00

abstract：:Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from laptops to petascale supercomputers, including combinations of these. Our work features t...

journal_title：Interface focus

authors： Groen D,Borgdorff J,Bona-Casas C,Hetherington J,Nash RW,Zasada SJ,Saverchenko I,Mamonski M,Kurowski K,Bernabeu MO,Hoekstra AG,Coveney PV

更新日期：2013-04-06 00:00:00

abstract：:In recent years, far from arguing that evolutionary approaches to our own species permit us to describe the fundamental character of human nature, a prominent group of cultural evolutionary theorists has instead argued that the very idea of 'human nature' is one we should reject. It makes no sense, they argue, to spea...

journal_title：Interface focus

authors： Lewens T

更新日期：2017-10-06 00:00:00

abstract：:'Managed grazing' is gaining attention for its potential to contribute to climate change mitigation by reducing bare ground and promoting perennialization, thereby enhancing soil carbon sequestration (SCS). Understanding why ranchers adopt managed grazing is key to developing the right incentives. In this paper, we ex...

journal_title：Interface focus

authors： Gosnell H,Charnley S,Stanley P

更新日期：2020-10-06 00:00:00

abstract：:We propose that fungi Basidiomycetes can be used as computing devices: information is represented by spikes of electrical activity, a computation is implemented in a mycelium network and an interface is realized via fruit bodies. In a series of scoping experiments, we demonstrate that electrical activity recorded on f...

journal_title：Interface focus

authors： Adamatzky A

更新日期：2018-12-06 00:00:00

abstract：:A numerical model for orthogonal cutting using the material point method was applied to woodcutting using a bench plane. The cutting process was modelled by accounting for surface energy associated with wood fracture toughness for crack growth parallel to the grain. By using damping to deal with dynamic crack propagat...

journal_title：Interface focus

authors： Nairn JA

更新日期：2016-06-06 00:00:00

abstract：:Eukaryogenesis-the process by which the eukaryotic cell emerged-has long puzzled scientists. It has been assumed that the fossil record has little to say about this process, in part because important characters such as the nucleus and mitochondria are rarely preserved, and in part because the prevailing model of early...

journal_title：Interface focus

authors： Porter SM

更新日期：2020-08-06 00:00:00

abstract：:Pentameric ligand-gated ion channels (pLGICs) are an important class of widely expressed membrane neuroreceptors, which play a crucial role in fast synaptic communications and are involved in several neurological conditions. They are activated by the binding of neurotransmitters, which trigger the transmission of an e...

journal_title：Interface focus

authors： Crnjar A,Comitani F,Melis C,Molteni C

更新日期：2019-06-06 00:00:00

abstract：:Recent advances in design, sensing and control have led to aerial robots that offer great promise in a range of real-world applications. However, one critical open question centres on how to improve the energetic efficiency of aerial robots so that they can be useful in practical situations. This review paper provides...

journal_title：Interface focus

authors： Karydis K,Kumar V

更新日期：2017-02-06 00:00:00