Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations.

Abstract:

:Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from laptops to petascale supercomputers, including combinations of these. Our work features two multiscale applications, in-stent restenosis and cerebrovascular bloodflow, which combine multiple existing single-scale applications to create a multiscale simulation. These applications can be efficiently coupled, deployed and executed on computers up to the largest (peta) scale, incurring a coupling overhead of 1-10% of the total execution time.

journal_name

Interface Focus

journal_title

Interface focus

authors

Groen D,Borgdorff J,Bona-Casas C,Hetherington J,Nash RW,Zasada SJ,Saverchenko I,Mamonski M,Kurowski K,Bernabeu MO,Hoekstra AG,Coveney PV

doi

10.1098/rsfs.2012.0087

subject

Has Abstract

pub_date

2013-04-06 00:00:00

pages

20120087

issue

2

eissn

2042-8898

issn

2042-8901

pii

rsfs20120087

journal_volume

3

pub_type

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