Abstract:
:Chemoattractant gradients are usually considered in terms of sources and sinks that are independent of the chemotactic cell. However, recent interest has focused on 'self-generated' gradients, in which cell populations create their own local gradients as they move. Here, we consider the interplay between chemoattractants and single cells. To achieve this, we extend a recently developed computational model to incorporate breakdown of extracellular attractants by membrane-bound enzymes. Model equations are parametrized, using the published estimates from Dictyostelium cells chemotaxing towards cyclic AMP. We find that individual cells can substantially modulate their local attractant field under physiologically appropriate conditions of attractant and enzymes. This means the attractant concentration perceived by receptors can be a small fraction of the ambient concentration. This allows efficient chemotaxis in chemoattractant concentrations that would be saturating without local breakdown. Similar interactions in which cells locally mould a stimulus could function in many types of directed cell motility, including haptotaxis, durotaxis and even electrotaxis.
journal_name
Interface Focusjournal_title
Interface focusauthors
Mackenzie JA,Nolan M,Insall RHdoi
10.1098/rsfs.2016.0036subject
Has Abstractpub_date
2016-10-06 00:00:00pages
20160036issue
5eissn
2042-8898issn
2042-8901pii
rsfs20160036journal_volume
6pub_type
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