Mesoporous silica nanoparticles equipped with surface nanovalves for pH-controlled liberation of doxorubicin.

abstract：:One of the predictions of game theory is that cooperative behaviours are vulnerable to exploitation by selfish individuals, but this result seemingly contradicts the survival of cooperation observed in nature. In this review, we will introduce game theoretical concepts that lead to this conclusion and show how the spa...

journal_title：Interface focus

authors： Lambert G,Vyawahare S,Austin RH

更新日期：2014-08-06 00:00:00

abstract：:Clinicians face many challenges when diagnosing and treating breast cancer. These challenges include interpreting and co-locating information between different medical imaging modalities that are used to identify tumours and predicting where these tumours move to during different treatment procedures. We have develope...

journal_title：Interface focus

authors： Babarenda Gamage TP,Malcolm DTK,Maso Talou G,Mîra A,Doyle A,Nielsen PMF,Nash MP

更新日期：2019-08-06 00:00:00

abstract：:We present the development of a tool, which provides users with the ability to visualize and interact with a comprehensive description of a multi-scale model of the renal nephron. A one-dimensional anatomical model of the nephron has been created and is used for visualization and modelling of tubule transport in vario...

journal_title：Interface focus

authors： Nickerson DP,Terkildsen JR,Hamilton KL,Hunter PJ

更新日期：2011-06-06 00:00:00

abstract：:Periodontitis is a polymicrobial, biofilm-caused, inflammatory disease affecting the tooth-supporting tissues. It is not only the leading cause of tooth loss worldwide, but can also impact systemic health. The development of effective treatment strategies is hampered by the complicated disease pathogenesis which is be...

journal_title：Interface focus

authors： Bloch S,Tomek MB,Friedrich V,Messner P,Schäffer C

更新日期：2019-04-06 00:00:00

abstract：:The development of bioadhesives inspired from marine animals is a promising approach to generate new tissue-compatible medical components. A number of marine species, through their adhesive properties, also represent significant foulers that become increasingly problematic to aquaculture, shipping or local biodiversit...

journal_title：Interface focus

authors： Pennati R,Rothbächer U

更新日期：2015-02-06 00:00:00

abstract：:The bulk mechanical properties of tissues are highly tuned to the physiological loads they experience and reflect the hierarchical structure and mechanical properties of their constituent parts. A thorough understanding of the processes involved in tissue adaptation is required to develop multi-scale computational mod...

journal_title：Interface focus

authors： Susilo ME,Paten JA,Sander EA,Nguyen TD,Ruberti JW

更新日期：2016-02-06 00:00:00

abstract：:Chemoattractant gradients are usually considered in terms of sources and sinks that are independent of the chemotactic cell. However, recent interest has focused on 'self-generated' gradients, in which cell populations create their own local gradients as they move. Here, we consider the interplay between chemoattracta...

journal_title：Interface focus

authors： Mackenzie JA,Nolan M,Insall RH

更新日期：2016-10-06 00:00:00

abstract：:Cell migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. The cells specifically migrate to destiny sites induced by the gradually varying conce...

journal_title：Interface focus

authors： Wu J,Mao Z,Tan H,Han L,Ren T,Gao C

更新日期：2012-06-06 00:00:00

abstract：:Multi-site enzymes, defined as where multiple substrate molecules can bind simultaneously to the same enzyme molecule, play a key role in a number of biological networks, with the Escherichia coli protease ClpXP a well-studied example. These enzymes can form a low latency 'waiting line' of substrate to the enzyme's ca...

journal_title：Interface focus

authors： Hochendoner P,Ogle C,Mather WH

更新日期：2014-06-06 00:00:00

abstract：:We construct the components for a family of computational models of the electrophysiology of the human foetal heart from 60 days gestational age (DGA) to full term. This requires both cell excitation models that reconstruct the myocyte action potentials, and datasets of cardiac geometry and architecture. Fast low-angl...

journal_title：Interface focus

authors： Pervolaraki E,Anderson RA,Benson AP,Hayes-Gill B,Holden AV,Moore BJ,Paley MN,Zhang H

更新日期：2013-04-06 00:00:00

abstract：:We investigate, by molecular dynamics simulation, the behaviour of discotic particles in a solvent of Lennard-Jones spheres. When chromonic disc-sphere interactions are imposed on these systems, three regimes of self-assembly are observed. At moderate temperatures, numerous short threads of discs develop, but these th...

journal_title：Interface focus

authors： Prybytak P,Frith WJ,Cleaver DJ

更新日期：2012-10-06 00:00:00

abstract：:Moving from homogeneous water-splitting photocatalytic systems to photoelectrochemical devices requires the preparation and evaluation of novel p-type transparent conductive photoelectrode substrates. We report here on the sensitization of polystyrene-block-poly-(2-vinylpyridine) (PS-b-P2VP) diblock copolymer-template...

journal_title：Interface focus

authors： Massin J,Bräutigam M,Kaeffer N,Queyriaux N,Field MJ,Schacher FH,Popp J,Chavarot-Kerlidou M,Dietzek B,Artero V

更新日期：2015-06-06 00:00:00

abstract：:How did people in the sixteenth and seventeenth centuries account for sleep loss? This article answers this question through an in-depth analysis of the life-writings of six early modern women and men that suffered from periodic or persistent episodes of sleep loss. It focuses on the ways in which these health crises ...

journal_title：Interface focus

authors： Handley S

更新日期：2020-06-06 00:00:00

abstract：:Pentameric ligand-gated ion channels (pLGICs) are an important class of widely expressed membrane neuroreceptors, which play a crucial role in fast synaptic communications and are involved in several neurological conditions. They are activated by the binding of neurotransmitters, which trigger the transmission of an e...

journal_title：Interface focus

authors： Crnjar A,Comitani F,Melis C,Molteni C

更新日期：2019-06-06 00:00:00

abstract：:Recent advances in design, sensing and control have led to aerial robots that offer great promise in a range of real-world applications. However, one critical open question centres on how to improve the energetic efficiency of aerial robots so that they can be useful in practical situations. This review paper provides...

journal_title：Interface focus

authors： Karydis K,Kumar V

更新日期：2017-02-06 00:00:00

abstract：:In recent years, there has been a move away from the use of static in vitro two-dimensional cell culture models for testing the chemical safety and efficacy of drugs. Such models are increasingly being replaced by more physiologically relevant cell culture systems featuring dynamic flow and/or three-dimensional struct...

journal_title：Interface focus

authors： Hyndman L,McKee S,Mottram NJ,Singh B,Webb SD,McGinty S

更新日期：2020-04-06 00:00:00

abstract：:The morphology of the toe epithelium of the rock frog, Staurois parvus (Family Ranidae), was investigated using a variety of microscopical techniques. The toe pad epithelium is stratified (four to five cell layers), the apical parts of the cells of the outermost layer being separated by fluid-filled channels. The surf...

journal_title：Interface focus

authors： Drotlef DM,Appel E,Peisker H,Dening K,Del Campo A,Gorb SN,Barnes WJ

更新日期：2015-02-06 00:00:00

abstract：:Dynamic remodelling of actin stress fibres (SFs) allows non-muscle cells to adapt to applied forces such as uniaxial cell shortening. However, the mechanism underlying rapid and selective disassembly of SFs oriented in the direction of shortening remains to be elucidated. Here, we investigated how myosin crossbridge c...

journal_title：Interface focus

authors： Matsui TS,Kaunas R,Kanzaki M,Sato M,Deguchi S

更新日期：2011-10-06 00:00:00

abstract：:Eukaryogenesis-the process by which the eukaryotic cell emerged-has long puzzled scientists. It has been assumed that the fossil record has little to say about this process, in part because important characters such as the nucleus and mitochondria are rarely preserved, and in part because the prevailing model of early...

journal_title：Interface focus

authors： Porter SM

更新日期：2020-08-06 00:00:00

abstract：:Noble metal nanoparticles (NPs) show distinctive plasmonic optical properties and superior photostability, enabling them to serve as photostable multi-coloured optical molecular probes and sensors for real-time in vivo imaging. To effectively study biological functions in vivo, it is essential that the NP probes are b...

journal_title：Interface focus

authors： Browning LM,Huang T,Xu XH

更新日期：2013-06-06 00:00:00

abstract：:The ability of the baby to receive nutrients and oxygen in utero depends on the healthy development of the placenta. For maternal blood to adequately perfuse the placenta, it dramatically alters the arteries in the uterus that supply it with nutrient-rich blood right from the start of pregnancy. Placental cells (troph...

journal_title：Interface focus

authors： Saghian R,Bogle G,James JL,Clark AR

更新日期：2019-10-06 00:00:00

abstract：:In recent years, far from arguing that evolutionary approaches to our own species permit us to describe the fundamental character of human nature, a prominent group of cultural evolutionary theorists has instead argued that the very idea of 'human nature' is one we should reject. It makes no sense, they argue, to spea...

journal_title：Interface focus

authors： Lewens T

更新日期：2017-10-06 00:00:00

abstract：:This article uses an integrative systems biological view of the relationship between genotypes and phenotypes to clarify some conceptual problems in biological debates about causality. The differential (gene-centric) view is incomplete in a sense analogous to using differentiation without integration in mathematics. D...

journal_title：Interface focus

authors： Noble D

更新日期：2011-02-06 00:00:00

abstract：:Yves Bouligand's analysis of the organizations of biological materials in relation to those of liquid crystals enabled the development of the idea that physical forces exerting their actions under strong spatial constraints determine the structures and morphologies of these materials. The different levels of organizat...

journal_title：Interface focus

authors： Charvolin J,Sadoc JF

更新日期：2012-10-06 00:00:00

abstract：:Biofuels have gained increasing attention as an alternative to fossil fuels for several reasons, one of which is their potential to reduce the greenhouse gas (GHG) emissions from the transportation sector. Recent studies have questioned the validity of claims about the potential of biofuels to reduce GHG emissions rel...

journal_title：Interface focus

authors： Khanna M,Crago CL,Black M

更新日期：2011-04-06 00:00:00

abstract：:Visual memory is crucial to navigation in many animals, including insects. Here, we focus on the problem of visual homing, that is, using comparison of the view at a current location with a view stored at the home location to control movement towards home by a novel shortcut. Insects show several visual specialization...

journal_title：Interface focus

authors： Stone T,Mangan M,Wystrach A,Webb B

更新日期：2018-08-06 00:00:00

abstract：:There is a growing need for patient-specific and holistic modelling of the heart to support comprehensive disease assessment and intervention planning as well as prediction of therapeutic outcomes. We propose a patient-specific model of the whole human heart, which integrates morphology, dynamics and haemodynamic para...

journal_title：Interface focus

authors： Mihalef V,Ionasec RI,Sharma P,Georgescu B,Voigt I,Suehling M,Comaniciu D

更新日期：2011-06-06 00:00:00

abstract：:A novel class of ultra-thin fibres, which affect microbial growth, were explored. The microbial properties of poly(methyl methacrylate) fibres containing 2, 4 and 8 wt% of graphene nanoplatelets (GNPs) were studied. GNPs were dispersed in a polymeric solution and processed using pressurized gyration. Electron microsco...

journal_title：Interface focus

authors： Matharu RK,Porwal H,Ciric L,Edirisinghe M

更新日期：2018-06-06 00:00:00

abstract：:Owls are an order of birds of prey that are known for the development of a silent flight. We review here the morphological adaptations of owls leading to silent flight and discuss also aerodynamic properties of owl wings. We start with early observations (until 2005), and then turn to recent advances. The large wings ...

journal_title：Interface focus

authors： Wagner H,Weger M,Klaas M,Schröder W

更新日期：2017-02-06 00:00:00

abstract：:Mental time travel allows us to revisit our memories and imagine future scenarios, and this is why memories are not only about the past, but they are also prospective. These episodic memories are not a fixed store of what happened, however, they are reassessed each time they are revisited and depend on the sequence in...

journal_title：Interface focus

authors： Clayton N,Wilkins C

更新日期：2017-06-06 00:00:00