Abstract:
:There is a growing need for patient-specific and holistic modelling of the heart to support comprehensive disease assessment and intervention planning as well as prediction of therapeutic outcomes. We propose a patient-specific model of the whole human heart, which integrates morphology, dynamics and haemodynamic parameters at the organ level. The modelled cardiac structures are robustly estimated from four-dimensional cardiac computed tomography (CT), including all four chambers and valves as well as the ascending aorta and pulmonary artery. The patient-specific geometry serves as an input to a three-dimensional Navier-Stokes solver that derives realistic haemodynamics, constrained by the local anatomy, along the entire heart cycle. We evaluated our framework with various heart pathologies and the results correlate with relevant literature reports.
journal_name
Interface Focusjournal_title
Interface focusauthors
Mihalef V,Ionasec RI,Sharma P,Georgescu B,Voigt I,Suehling M,Comaniciu Ddoi
10.1098/rsfs.2010.0036subject
Has Abstractpub_date
2011-06-06 00:00:00pages
286-96issue
3eissn
2042-8898issn
2042-8901pii
rsfs20100036journal_volume
1pub_type
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