A model of ionic transport and osmotic volume control in cochlear outer hair cells.

Abstract:

:A computational model of the outer hair cell (OHC) of the mammalian cochlea is presented. It addresses the way in which movement of ions controls the cell shape and regulates pH. The model takes into account the possible chloride-bicarbonate exchange function of prestin, a protein highly expressed in the plasma membrane of OHCs. A model of intracellular pH transients following the imposition of a rapid acid load upon the cell has been adapted from the squid axon literature and further extended in order to investigate the effects of ion transport upon the osmotic flux of water into the cell. The model predicts the slow length changes of OHCs reported in the literature a feature which may control the contribution of OHCs to cochlear amplification.

journal_name

Interface Focus

journal_title

Interface focus

authors

West T,Ashmore J

doi

10.1098/rsfs.2014.0018

subject

Has Abstract

pub_date

2014-12-06 00:00:00

pages

20140018

issue

6

eissn

2042-8898

issn

2042-8901

pii

rsfs20140018

journal_volume

4

pub_type

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