A theory of biological relativity: no privileged level of causation.

Abstract:

:Must higher level biological processes always be derivable from lower level data and mechanisms, as assumed by the idea that an organism is completely defined by its genome? Or are higher level properties necessarily also causes of lower level behaviour, involving actions and interactions both ways? This article uses modelling of the heart, and its experimental basis, to show that downward causation is necessary and that this form of causation can be represented as the influences of initial and boundary conditions on the solutions of the differential equations used to represent the lower level processes. These insights are then generalized. A priori, there is no privileged level of causation. The relations between this form of 'biological relativity' and forms of relativity in physics are discussed. Biological relativity can be seen as an extension of the relativity principle by avoiding the assumption that there is a privileged scale at which biological functions are determined.

journal_name

Interface Focus

journal_title

Interface focus

authors

Noble D

doi

10.1098/rsfs.2011.0067

subject

Has Abstract

pub_date

2012-02-06 00:00:00

pages

55-64

issue

1

eissn

2042-8898

issn

2042-8901

pii

rsfs20110067

journal_volume

2

pub_type

杂志文章
  • Bioadhesion in ascidians: a developmental and functional genomics perspective.

    abstract::The development of bioadhesives inspired from marine animals is a promising approach to generate new tissue-compatible medical components. A number of marine species, through their adhesive properties, also represent significant foulers that become increasingly problematic to aquaculture, shipping or local biodiversit...

    journal_title:Interface focus

    pub_type: 杂志文章,评审

    doi:10.1098/rsfs.2014.0061

    authors: Pennati R,Rothbächer U

    更新日期:2015-02-06 00:00:00

  • Survival dynamical systems: individual-level survival analysis from population-level epidemic models.

    abstract::In this paper, we show that solutions to ordinary differential equations describing the large-population limits of Markovian stochastic epidemic models can be interpreted as survival or cumulative hazard functions when analysing data on individuals sampled from the population. We refer to the individual-level survival...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2019.0048

    authors: KhudaBukhsh WR,Choi B,Kenah E,Rempała GA

    更新日期:2020-02-06 00:00:00

  • Features of owl wings that promote silent flight.

    abstract::Owls are an order of birds of prey that are known for the development of a silent flight. We review here the morphological adaptations of owls leading to silent flight and discuss also aerodynamic properties of owl wings. We start with early observations (until 2005), and then turn to recent advances. The large wings ...

    journal_title:Interface focus

    pub_type: 杂志文章,评审

    doi:10.1098/rsfs.2016.0078

    authors: Wagner H,Weger M,Klaas M,Schröder W

    更新日期:2017-02-06 00:00:00

  • Biomechanical analysis of intact versus ruptured Poly Implant Prothèse breast implants.

    abstract::Despite there being many studies that have evaluated breast implant rupture, there is no consensus about causes and incidence. Most studies lack a multifactorial analysis of what causes breast implants to rupture. To fill this gap, an experimental protocol was developed to compare ruptured and intact Poly Implant Prot...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2018.0086

    authors: Ramião NG,Martins PS,Barroso ML,Santos DC,Fernandes AA

    更新日期:2019-08-06 00:00:00

  • Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations.

    abstract::Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from laptops to petascale supercomputers, including combinations of these. Our work features t...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2012.0087

    authors: Groen D,Borgdorff J,Bona-Casas C,Hetherington J,Nash RW,Zasada SJ,Saverchenko I,Mamonski M,Kurowski K,Bernabeu MO,Hoekstra AG,Coveney PV

    更新日期:2013-04-06 00:00:00

  • Multiscale musculoskeletal modelling, data-model fusion and electromyography-informed modelling.

    abstract::This paper proposes methods and technologies that advance the state of the art for modelling the musculoskeletal system across the spatial and temporal scales; and storing these using efficient ontologies and tools. We present population-based modelling as an efficient method to rapidly generate individual morphology ...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2015.0084

    authors: Fernandez J,Zhang J,Heidlauf T,Sartori M,Besier T,Röhrle O,Lloyd D

    更新日期:2016-04-06 00:00:00

  • Coherent backscattering of light by an anisotropic biological network.

    abstract::The scattering strength of a random medium relies on the geometry and spatial distribution of its components as well as on their refractive index. Anisotropy can, therefore, play a major role in the optimization of the scattering efficiency in both biological and synthetic materials. In this study, we show that, by ex...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2018.0050

    authors: Jacucci G,Onelli OD,De Luca A,Bertolotti J,Sapienza R,Vignolini S

    更新日期:2019-02-06 00:00:00

  • Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content.

    abstract::Pancreatic β-cells use Ca(2+)-dependent exocytosis of large dense core vesicles to release insulin. Exocytosis in β-cells has been studied biochemically, biophysically and optically. We have previously developed a biophysical method to monitor release of endogenous intragranular constituents that are co-released with ...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2010.0006

    authors: Galvanovskis J,Braun M,Rorsman P

    更新日期:2011-02-06 00:00:00

  • Radionuclide-induced defect sites in iron-bearing minerals may have accelerated the emergence of life.

    abstract::The emergence of life on Earth (and elsewhere) must have occurred in a milieu that is far from equilibrium, such as at alkaline hydrothermal vents that would have harboured built-in gradients in temperature, redox potential and pH along with precipitated iron-bearing minerals capable of separating these gradients, con...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2019.0085

    authors: Ponce A

    更新日期:2019-12-06 00:00:00

  • Real-time quasi-static ultrasound elastography.

    abstract::Ultrasound elastography is a technique used for clinical imaging of tissue stiffness with a conventional ultrasound machine. It was first proposed two decades ago, but active research continues in this area to the present day. Numerous clinical applications have been investigated, mostly related to cancer imaging, and...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2011.0011

    authors: Treece G,Lindop J,Chen L,Housden J,Prager R,Gee A

    更新日期:2011-08-06 00:00:00

  • Modelling cavitation erosion using fluid-material interaction simulations.

    abstract::Material deformation and pitting from cavitation bubble collapse is investigated using fluid and material dynamics and their interaction. In the fluid, a novel hybrid approach, which links a boundary element method and a compressible finite difference method, is used to capture non-spherical bubble dynamics and result...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2015.0016

    authors: Chahine GL,Hsiao CT

    更新日期:2015-10-06 00:00:00

  • The morphological state space revisited: what do phylogenetic patterns in homoplasy tell us about the number of possible character states?

    abstract::Biological variety and major evolutionary transitions suggest that the space of possible morphologies may have varied among lineages and through time. However, most models of phylogenetic character evolution assume that the potential state space is finite. Here, I explore what the morphological state space might be li...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2015.0049

    authors: Hoyal Cuthill JF

    更新日期:2015-12-06 00:00:00

  • Niche construction, sources of selection and trait coevolution.

    abstract::Organisms modify and choose components of their local environments. This 'niche construction' can alter ecological processes, modify natural selection and contribute to inheritance through ecological legacies. Here, we propose that niche construction initiates and modifies the selection directly affecting the construc...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2016.0147

    authors: Laland K,Odling-Smee J,Endler J

    更新日期:2017-10-06 00:00:00

  • Purely entropic self-assembly of the bicontinuous Ia3d gyroid phase in equilibrium hard-pear systems.

    abstract::We investigate a model of hard pear-shaped particles which forms the bicontinuous Ia[Formula: see text]d structure by entropic self-assembly, extending the previous observations of Barmes et al. (2003 Phys. Rev. E68, 021708. (doi:10.1103/PhysRevE.68.021708)) and Ellison et al. (2006 Phys. Rev. Lett.97, 237801. (doi:10...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2016.0161

    authors: Schönhöfer PWA,Ellison LJ,Marechal M,Cleaver DJ,Schröder-Turk GE

    更新日期:2017-08-06 00:00:00

  • Can biofuels be a solution to climate change? The implications of land use change-related emissions for policy.

    abstract::Biofuels have gained increasing attention as an alternative to fossil fuels for several reasons, one of which is their potential to reduce the greenhouse gas (GHG) emissions from the transportation sector. Recent studies have questioned the validity of claims about the potential of biofuels to reduce GHG emissions rel...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2010.0016

    authors: Khanna M,Crago CL,Black M

    更新日期:2011-04-06 00:00:00

  • Real-time in vivo imaging of size-dependent transport and toxicity of gold nanoparticles in zebrafish embryos using single nanoparticle plasmonic spectroscopy.

    abstract::Noble metal nanoparticles (NPs) show distinctive plasmonic optical properties and superior photostability, enabling them to serve as photostable multi-coloured optical molecular probes and sensors for real-time in vivo imaging. To effectively study biological functions in vivo, it is essential that the NP probes are b...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2012.0098

    authors: Browning LM,Huang T,Xu XH

    更新日期:2013-06-06 00:00:00

  • Morphological studies of the toe pads of the rock frog, Staurois parvus (family: Ranidae) and their relevance to the development of new biomimetically inspired reversible adhesives.

    abstract::The morphology of the toe epithelium of the rock frog, Staurois parvus (Family Ranidae), was investigated using a variety of microscopical techniques. The toe pad epithelium is stratified (four to five cell layers), the apical parts of the cells of the outermost layer being separated by fluid-filled channels. The surf...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2014.0036

    authors: Drotlef DM,Appel E,Peisker H,Dening K,Del Campo A,Gorb SN,Barnes WJ

    更新日期:2015-02-06 00:00:00

  • Human nature, human culture: the case of cultural evolution.

    abstract::In recent years, far from arguing that evolutionary approaches to our own species permit us to describe the fundamental character of human nature, a prominent group of cultural evolutionary theorists has instead argued that the very idea of 'human nature' is one we should reject. It makes no sense, they argue, to spea...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2017.0018

    authors: Lewens T

    更新日期:2017-10-06 00:00:00

  • Polyelectrolyte coating on superparamagnetic iron oxide nanoparticles as interface between magnetic core and biorelevant media.

    abstract::Nanoparticles do not exist in thermodynamical equilibrium because of high surface free energy, thus they have only kinetic stability. Spontaneous changes can be delayed by designed surface coating. In biomedical applications, superparamagnetic iron oxide nanoparticles (SPIONs) require an optimized coating in order to ...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2016.0068

    authors: Tombácz E,Farkas K,Földesi I,Szekeres M,Illés E,Tóth IY,Nesztor D,Szabó T

    更新日期:2016-12-06 00:00:00

  • Joining or opting out of a Lotka-Volterra game between predators and prey: does the best strategy depend on modelling energy lost and gained?

    abstract::Apart from interacting, prey and predators may also avoid each other by moving into refuges where they lack food, yet survive by switching to an energy-saving physiological state. Lotka-Volterra models of predator-prey interactions ignore this option. Therefore, we have modelled this game of 'joining versus opting out...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2013.0034

    authors: Staňková K,Abate A,Sabelis MW,Buša J,You L

    更新日期:2013-12-06 00:00:00

  • The logic of ecological patchiness.

    abstract::Most ecological interactions occur in environments that are spatially and temporally heterogeneous-'patchy'-across a wide range of scales. In contrast, most theoretical models of ecological interactions, especially large-scale models applied to societal issues such as climate change, resource management and human heal...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2011.0084

    authors: Grünbaum D

    更新日期:2012-04-06 00:00:00

  • Dye-sensitized PS-b-P2VP-templated nickel oxide films for photoelectrochemical applications.

    abstract::Moving from homogeneous water-splitting photocatalytic systems to photoelectrochemical devices requires the preparation and evaluation of novel p-type transparent conductive photoelectrode substrates. We report here on the sensitization of polystyrene-block-poly-(2-vinylpyridine) (PS-b-P2VP) diblock copolymer-template...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2014.0083

    authors: Massin J,Bräutigam M,Kaeffer N,Queyriaux N,Field MJ,Schacher FH,Popp J,Chavarot-Kerlidou M,Dietzek B,Artero V

    更新日期:2015-06-06 00:00:00

  • Non-muscle myosin II induces disassembly of actin stress fibres independently of myosin light chain dephosphorylation.

    abstract::Dynamic remodelling of actin stress fibres (SFs) allows non-muscle cells to adapt to applied forces such as uniaxial cell shortening. However, the mechanism underlying rapid and selective disassembly of SFs oriented in the direction of shortening remains to be elucidated. Here, we investigated how myosin crossbridge c...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2011.0031

    authors: Matsui TS,Kaunas R,Kanzaki M,Sato M,Deguchi S

    更新日期:2011-10-06 00:00:00

  • A model of ionic transport and osmotic volume control in cochlear outer hair cells.

    abstract::A computational model of the outer hair cell (OHC) of the mammalian cochlea is presented. It addresses the way in which movement of ions controls the cell shape and regulates pH. The model takes into account the possible chloride-bicarbonate exchange function of prestin, a protein highly expressed in the plasma membra...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2014.0018

    authors: West T,Ashmore J

    更新日期:2014-12-06 00:00:00

  • Collagen network strengthening following cyclic tensile loading.

    abstract::The bulk mechanical properties of tissues are highly tuned to the physiological loads they experience and reflect the hierarchical structure and mechanical properties of their constituent parts. A thorough understanding of the processes involved in tissue adaptation is required to develop multi-scale computational mod...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2015.0088

    authors: Susilo ME,Paten JA,Sander EA,Nguyen TD,Ruberti JW

    更新日期:2016-02-06 00:00:00

  • About collagen, a tribute to Yves Bouligand.

    abstract::Yves Bouligand's analysis of the organizations of biological materials in relation to those of liquid crystals enabled the development of the idea that physical forces exerting their actions under strong spatial constraints determine the structures and morphologies of these materials. The different levels of organizat...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2012.0014

    authors: Charvolin J,Sadoc JF

    更新日期:2012-10-06 00:00:00

  • Numerical modelling of orthogonal cutting: application to woodworking with a bench plane.

    abstract::A numerical model for orthogonal cutting using the material point method was applied to woodcutting using a bench plane. The cutting process was modelled by accounting for surface energy associated with wood fracture toughness for crack growth parallel to the grain. By using damping to deal with dynamic crack propagat...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2015.0110

    authors: Nairn JA

    更新日期:2016-06-06 00:00:00

  • Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention.

    abstract::In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabo...

    journal_title:Interface focus

    pub_type: 杂志文章,评审

    doi:10.1098/rsfs.2016.0104

    authors: Galkin A,Moncada S

    更新日期:2017-04-06 00:00:00

  • Climate change mitigation as a co-benefit of regenerative ranching: insights from Australia and the United States.

    abstract::'Managed grazing' is gaining attention for its potential to contribute to climate change mitigation by reducing bare ground and promoting perennialization, thereby enhancing soil carbon sequestration (SCS). Understanding why ranchers adopt managed grazing is key to developing the right incentives. In this paper, we ex...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2020.0027

    authors: Gosnell H,Charnley S,Stanley P

    更新日期:2020-10-06 00:00:00

  • Multiscale modelling of the feto-placental vasculature.

    abstract::The placenta provides all the nutrients required for the fetus through pregnancy. It develops dynamically, and, to avoid rejection of the fetus, there is no mixing of fetal and maternal blood; rather, the branched placental villi 'bathe' in blood supplied from the uterine arteries. Within the villi, the feto-placental...

    journal_title:Interface focus

    pub_type: 杂志文章

    doi:10.1098/rsfs.2014.0078

    authors: Clark AR,Lin M,Tawhai M,Saghian R,James JL

    更新日期:2015-04-06 00:00:00