Mutagenesis computer experiments in pentameric ligand-gated ion channels: the role of simulation tools with different resolution.

abstract：:The paper reviews two computing models by DNA self-assembly whose proof of principal have recently been experimentally confirmed. The first model incorporates DNA nano-devices and triple crossover DNA molecules to algorithmically arrange non-DNA species. This is achieved by simulating a finite-state automaton with out...

journal_title：Interface focus

authors： Jonoska N,Seeman NC

更新日期：2012-08-06 00:00:00

abstract：:Recent advances in design, sensing and control have led to aerial robots that offer great promise in a range of real-world applications. However, one critical open question centres on how to improve the energetic efficiency of aerial robots so that they can be useful in practical situations. This review paper provides...

journal_title：Interface focus

authors： Karydis K,Kumar V

更新日期：2017-02-06 00:00:00

abstract：:Pancreatic β-cells use Ca(2+)-dependent exocytosis of large dense core vesicles to release insulin. Exocytosis in β-cells has been studied biochemically, biophysically and optically. We have previously developed a biophysical method to monitor release of endogenous intragranular constituents that are co-released with ...

journal_title：Interface focus

authors： Galvanovskis J,Braun M,Rorsman P

更新日期：2011-02-06 00:00:00

abstract：:The emergence of life on Earth (and elsewhere) must have occurred in a milieu that is far from equilibrium, such as at alkaline hydrothermal vents that would have harboured built-in gradients in temperature, redox potential and pH along with precipitated iron-bearing minerals capable of separating these gradients, con...

journal_title：Interface focus

authors： Ponce A

更新日期：2019-12-06 00:00:00

abstract：:In this paper, we show that solutions to ordinary differential equations describing the large-population limits of Markovian stochastic epidemic models can be interpreted as survival or cumulative hazard functions when analysing data on individuals sampled from the population. We refer to the individual-level survival...

journal_title：Interface focus

authors： KhudaBukhsh WR,Choi B,Kenah E,Rempała GA

更新日期：2020-02-06 00:00:00

abstract：:Periodontitis is a polymicrobial, biofilm-caused, inflammatory disease affecting the tooth-supporting tissues. It is not only the leading cause of tooth loss worldwide, but can also impact systemic health. The development of effective treatment strategies is hampered by the complicated disease pathogenesis which is be...

journal_title：Interface focus

authors： Bloch S,Tomek MB,Friedrich V,Messner P,Schäffer C

更新日期：2019-04-06 00:00:00

abstract：:Clinicians face many challenges when diagnosing and treating breast cancer. These challenges include interpreting and co-locating information between different medical imaging modalities that are used to identify tumours and predicting where these tumours move to during different treatment procedures. We have develope...

journal_title：Interface focus

authors： Babarenda Gamage TP,Malcolm DTK,Maso Talou G,Mîra A,Doyle A,Nielsen PMF,Nash MP

更新日期：2019-08-06 00:00:00

abstract：:The morphology of the toe epithelium of the rock frog, Staurois parvus (Family Ranidae), was investigated using a variety of microscopical techniques. The toe pad epithelium is stratified (four to five cell layers), the apical parts of the cells of the outermost layer being separated by fluid-filled channels. The surf...

journal_title：Interface focus

authors： Drotlef DM,Appel E,Peisker H,Dening K,Del Campo A,Gorb SN,Barnes WJ

更新日期：2015-02-06 00:00:00

abstract：:Biological variety and major evolutionary transitions suggest that the space of possible morphologies may have varied among lineages and through time. However, most models of phylogenetic character evolution assume that the potential state space is finite. Here, I explore what the morphological state space might be li...

journal_title：Interface focus

authors： Hoyal Cuthill JF

更新日期：2015-12-06 00:00:00

abstract：:In recent years, there has been a move away from the use of static in vitro two-dimensional cell culture models for testing the chemical safety and efficacy of drugs. Such models are increasingly being replaced by more physiologically relevant cell culture systems featuring dynamic flow and/or three-dimensional struct...

journal_title：Interface focus

authors： Hyndman L,McKee S,Mottram NJ,Singh B,Webb SD,McGinty S

更新日期：2020-04-06 00:00:00

abstract：:This paper proposes methods and technologies that advance the state of the art for modelling the musculoskeletal system across the spatial and temporal scales; and storing these using efficient ontologies and tools. We present population-based modelling as an efficient method to rapidly generate individual morphology ...

journal_title：Interface focus

authors： Fernandez J,Zhang J,Heidlauf T,Sartori M,Besier T,Röhrle O,Lloyd D

更新日期：2016-04-06 00:00:00

abstract：:Cell migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. The cells specifically migrate to destiny sites induced by the gradually varying conce...

journal_title：Interface focus

authors： Wu J,Mao Z,Tan H,Han L,Ren T,Gao C

更新日期：2012-06-06 00:00:00

abstract：:Formation of spatial patterns of cells is a recurring theme in biology and often depends on regulated cell motility. Motility of the rod-shaped cells of the bacterium Myxococcus xanthus depends on two motility machineries, type IV pili (giving rise to S-motility) and the gliding motility apparatus (giving rise to A-mo...

journal_title：Interface focus

authors： Starruß J,Peruani F,Jakovljevic V,Søgaard-Andersen L,Deutsch A,Bär M

更新日期：2012-12-06 00:00:00

abstract：:In areas of oil and gas exploration, seismic lines have been reported to alter the movement patterns of wolves (Canis lupus). We developed a mechanistic first passage time model, based on an anisotropic elliptic partial differential equation, and used this to explore how wolf movement responses to seismic lines influe...

journal_title：Interface focus

authors： McKenzie HW,Merrill EH,Spiteri RJ,Lewis MA

更新日期：2012-04-06 00:00:00

abstract：:[This corrects the article DOI: 10.1098/rsfs.2017.0015.]. ...

journal_title：Interface focus

authors： Müller GB

更新日期：2017-12-06 00:00:00

abstract：:Biominerals are typically indispensable structures for their host organism in which they serve varying functions, such as mechanical support and protection, mineral storage, detoxification site, or as a sensor or optical guide. In this perspective article, we highlight the occurrence of both structural diversity and u...

journal_title：Interface focus

authors： Harris J,Böhm CF,Wolf SE

更新日期：2017-08-06 00:00:00

abstract：:Most ecological interactions occur in environments that are spatially and temporally heterogeneous-'patchy'-across a wide range of scales. In contrast, most theoretical models of ecological interactions, especially large-scale models applied to societal issues such as climate change, resource management and human heal...

journal_title：Interface focus

authors： Grünbaum D

更新日期：2012-04-06 00:00:00

abstract：:Chemoattractant gradients are usually considered in terms of sources and sinks that are independent of the chemotactic cell. However, recent interest has focused on 'self-generated' gradients, in which cell populations create their own local gradients as they move. Here, we consider the interplay between chemoattracta...

journal_title：Interface focus

authors： Mackenzie JA,Nolan M,Insall RH

更新日期：2016-10-06 00:00:00

abstract：:Noble metal nanoparticles (NPs) show distinctive plasmonic optical properties and superior photostability, enabling them to serve as photostable multi-coloured optical molecular probes and sensors for real-time in vivo imaging. To effectively study biological functions in vivo, it is essential that the NP probes are b...

journal_title：Interface focus

authors： Browning LM,Huang T,Xu XH

更新日期：2013-06-06 00:00:00

abstract：:Biofuels production from microalgae attracts much attention but remains an unproven technology. We explore routes to enhance production through modifications to a range of generic microalgal physiological characteristics. Our analysis shows that biofuels production may be enhanced ca fivefold through genetic modificat...

journal_title：Interface focus

authors： Flynn KJ,Mitra A,Greenwell HC,Sui J

更新日期：2013-02-06 00:00:00

abstract：:Must higher level biological processes always be derivable from lower level data and mechanisms, as assumed by the idea that an organism is completely defined by its genome? Or are higher level properties necessarily also causes of lower level behaviour, involving actions and interactions both ways? This article uses ...

journal_title：Interface focus

authors： Noble D

更新日期：2012-02-06 00:00:00

abstract：:Apart from interacting, prey and predators may also avoid each other by moving into refuges where they lack food, yet survive by switching to an energy-saving physiological state. Lotka-Volterra models of predator-prey interactions ignore this option. Therefore, we have modelled this game of 'joining versus opting out...

journal_title：Interface focus

authors： Staňková K,Abate A,Sabelis MW,Buša J,You L

更新日期：2013-12-06 00:00:00

abstract：:Multi-site enzymes, defined as where multiple substrate molecules can bind simultaneously to the same enzyme molecule, play a key role in a number of biological networks, with the Escherichia coli protease ClpXP a well-studied example. These enzymes can form a low latency 'waiting line' of substrate to the enzyme's ca...

journal_title：Interface focus

authors： Hochendoner P,Ogle C,Mather WH

更新日期：2014-06-06 00:00:00

abstract：:Blood glucose levels are controlled by well-known physiological feedback loops: high glucose levels promote insulin release from the pancreas, which in turn stimulates cellular glucose uptake. Low blood glucose levels promote pancreatic glucagon release, stimulating glycogen breakdown to glucose in the liver. In healt...

journal_title：Interface focus

authors： Csete M,Doyle J

更新日期：2014-10-06 00:00:00

abstract：:Silica carriers equipped with molecular and supramolecular pH-sensitive nanovalves were designed by combination of sol-gel synthesis and selective postsynthetic modification. Mesoporous structure of synthesized materials was characterized by low-temperature nitrogen adsorption-desorption, small-angle X-ray diffraction...

journal_title：Interface focus

authors： Roik NV,Belyakova LA

更新日期：2016-12-06 00:00:00

abstract：:How did people in the sixteenth and seventeenth centuries account for sleep loss? This article answers this question through an in-depth analysis of the life-writings of six early modern women and men that suffered from periodic or persistent episodes of sleep loss. It focuses on the ways in which these health crises ...

journal_title：Interface focus

authors： Handley S

更新日期：2020-06-06 00:00:00

abstract：:Eukaryogenesis-the process by which the eukaryotic cell emerged-has long puzzled scientists. It has been assumed that the fossil record has little to say about this process, in part because important characters such as the nucleus and mitochondria are rarely preserved, and in part because the prevailing model of early...

journal_title：Interface focus

authors： Porter SM

更新日期：2020-08-06 00:00:00

abstract：:A tumour is a heterogeneous population of cells that competes for limited resources. In the clinic, we typically probe the tumour by biopsy, and then characterize it by the dominant genetic clone. But genotypes are only the first link in the chain of hierarchical events that leads to a specific cell phenotype. The rel...

journal_title：Interface focus

authors： Gallaher J,Anderson AR

更新日期：2013-08-06 00:00:00

abstract：:The combination of high strength and high toughness is a desirable feature that structural materials should display. However, while in the past, engineers had to compromise on either strength or toughness depending on the requested application, nowadays, new toughening strategies are available to provide strong materi...

journal_title：Interface focus

authors： Berardo A,Pantano MF,Pugno NM

更新日期：2016-02-06 00:00:00

abstract：:Ultrasound elastography is a technique used for clinical imaging of tissue stiffness with a conventional ultrasound machine. It was first proposed two decades ago, but active research continues in this area to the present day. Numerous clinical applications have been investigated, mostly related to cancer imaging, and...

journal_title：Interface focus

authors： Treece G,Lindop J,Chen L,Housden J,Prager R,Gee A

更新日期：2011-08-06 00:00:00