HCMV-encoded miR-UL112-3p promotes glioblastoma progression via tumour suppressor candidate 3.

abstract：:Ocean warming increasingly endangers the fitness of marine invertebrates. Transgenerational effects (TE) potentially mitigate the impacts of environmental stress on the embryos of marine invertebrates. The molecular mechanisms, however, remain largely unknown. Using high-throughput RNA sequencing technology, we invest...

journal_title：Scientific reports

authors： Shi D,Zhao C,Chen Y,Ding J,Zhang L,Chang Y

更新日期：2020-05-13 00:00:00

abstract：:Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression wa...

journal_title：Scientific reports

authors： Zhang SF,Chen JC,Zhang J,Xu JG

更新日期：2017-08-16 00:00:00

abstract：:The optimized strategy to further increase the success rate of ablation for ventricular arrhythmias (VAs) from the right ventricular outflow tract (RVOT) is challenging. Recent studies have shown that the pulmonary sinus cusp (PSC) region may be the origin of certain RVOT VAs. We evaluated the efficacy of preferential...

journal_title：Scientific reports

authors： Xie Y,Liu A,Jin Q,Zhang N,Jia K,Lin C,Ling T,Chen K,Pan W,Wu L

更新日期：2020-10-20 00:00:00

abstract：:Known γ-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identified as direct inhibitors of γ-secretase. To search for bioactive mol...

journal_title：Scientific reports

authors： Lei X,Yu J,Niu Q,Liu J,Fraering PC,Wu F

更新日期：2015-11-16 00:00:00

abstract：:Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...

journal_title：Scientific reports

authors： Ranasinghe SL,Rivera V,Boyle GM,McManus DP

更新日期：2019-11-07 00:00:00

abstract：:Loss of seed shattering has been regarded as a key step during crop domestication. Mutagenesis contributes to the development of novel crop cultivars with a desired seed-shattering habit in a relatively short period of time, but also to uncovering the genetic architecture of seed shattering. 'Minamiyutaka', a non-shat...

journal_title：Scientific reports

authors： Li F,Komatsu A,Ohtake M,Eun H,Shimizu A,Kato H

更新日期：2020-09-10 00:00:00

abstract：:One of the health hazards of PM2.5 exposure is to induce pulmonary inflammatory responses. In our previous study, we demonstrated that exposing both the immortalized and primary human bronchial epithelial cells to PM2.5 results in a significant upregulation of VEGF production, a typical signaling event to trigger chro...

journal_title：Scientific reports

authors： Xu H,Xu X,Wang H,Qimuge A,Liu S,Chen Y,Zhang C,Hu M,Song L

更新日期：2019-11-12 00:00:00

abstract：:Using a non-targeted metabolomics platform, we recently identified C-mannosyltryptophan and pseudouridine as non-traditional kidney function markers. The aims of this study were to obtain absolute concentrations of both metabolites in blood and urine from individuals with and without CKD to provide reference ranges an...

journal_title：Scientific reports

authors： Sekula P,Dettmer K,Vogl FC,Gronwald W,Ellmann L,Mohney RP,Eckardt KU,Suhre K,Kastenmüller G,Oefner PJ,Köttgen A

更新日期：2017-12-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Nik ME,Malaekeh-Nikouei B,Amin M,Hatamipour M,Teymouri M,Sadeghnia HR,Iranshahi M,Jaafari MR

更新日期：2020-02-27 00:00:00

abstract：:B cells have been reported to promote graft rejection through alloantibody production. However, there is growing evidence that B cells can contribute to the maintenance of tolerance. Here, we used a mouse model of MHC-class I mismatched skin transplantation to investigate the contribution of B cells to graft survival....

journal_title：Scientific reports

authors： Alhabbab R,Blair P,Elgueta R,Stolarczyk E,Marks E,Becker PD,Ratnasothy K,Smyth L,Safinia N,Sharif-Paghaleh E,O'Connell S,Noelle RJ,Lord GM,Howard JK,Spencer J,Lechler RI,Lombardi G

更新日期：2015-06-25 00:00:00

abstract：:Canalization is a result of intrinsic developmental buffering that ensures phenotypic robustness under genetic variation and environmental perturbation. As a consequence, animal phenotypes are remarkably consistent within a species under a wide range of conditions, a property that seems contradictory to evolutionary c...

journal_title：Scientific reports

authors： Sato A,Kawashima T,Fujie M,Hughes S,Satoh N,Shimeld SM

更新日期：2015-11-18 00:00:00

abstract：:Polymer-supported nanozero-valent iron composites (D001-nZVI) were fabricated for the removal of lead ions from aqueous solutions by embedding nZVI into the porous polystyrene anion exchanger D001. Humic acid (HA) was selected as a model species because of its ubiquitous existence to gain insight into the influencing ...

journal_title：Scientific reports

authors： Wang L,Wei S,Jiang Z

更新日期：2020-11-12 00:00:00

abstract：:Accumulating of evidence suggests that activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) exacerbates early brain injury (EBI) following subarachnoid hemorrhage (SAH) by provoking pro-inflammatory and pro-apoptotic signaling. Myeloid differentiation primary response protein 88 (...

journal_title：Scientific reports

authors： Yan H,Zhang D,Wei Y,Ni H,Liang W,Zhang H,Hao S,Jin W,Li K,Hang CH

更新日期：2017-11-17 00:00:00

abstract：:Carbon nanomaterials' reactivity towards oxygen is very poor, limiting their potential applications. However, nitrogen doping is an established way to introduce active sites that facilitate interaction with gases. This boosts the materials' reactivity for bio-/gas sensing and enhances their catalytic performance for t...

journal_title：Scientific reports

authors： Scardamaglia M,Susi T,Struzzi C,Snyders R,Di Santo G,Petaccia L,Bittencourt C

更新日期：2017-08-11 00:00:00

abstract：:Deriving cell populations from human embryonic stem cells (hESCs) for cell-based therapy is considered a promising strategy to achieve functional cells, yet its translation to clinical practice depends on achieving fully defined differentiated cells. In this work, we generated a miRNA-responsive lethal mRNA construct ...

journal_title：Scientific reports

authors： Elovic E,Etzion S,Cohen S

更新日期：2019-10-10 00:00:00

abstract：:Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS ...

journal_title：Scientific reports

authors： Wang Y,Gao Z,Han Z,Liu Y,Yang H,Akkin T,Hogan CJ,Bischof JC

更新日期：2021-01-13 00:00:00

abstract：:Corticotropin releasing factor (CRF), a peptide hormone involved in the stress response, holds a key position in cardiovascular regulation. Here, we report that the central effect of CRF on cardiovascular activities is mediated by the posterior hypothalamic nucleus (PH), an important structure responsible for stress-i...

journal_title：Scientific reports

authors： Gao HR,Zhuang QX,Li B,Li HZ,Chen ZP,Wang JJ,Zhu JN

更新日期：2016-02-01 00:00:00

abstract：:Bone tissues have trabecular bone with a high bone turnover and cortical bone with a low turnover. The mechanisms by which the turnover rate of these bone tissues is determined remain unclear. Osteocytes secrete sclerostin, a Wnt/β-catenin signaling antagonist, and inhibit bone formation. We found that sclerostin expr...

journal_title：Scientific reports

authors： Koide M,Yamashita T,Murakami K,Uehara S,Nakamura K,Nakamura M,Matsushita M,Ara T,Yasuda H,Penninger JM,Takahashi N,Udagawa N,Kobayashi Y

更新日期：2020-08-13 00:00:00

abstract：:Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate the associated with increased susceptibility to T2D (30 cases, 10 controls) and fo...

journal_title：Scientific reports

authors： Chen YT,Lin WD,Liao WL,Tsai YC,Liao JW,Tsai FJ

更新日期：2020-09-30 00:00:00

abstract：:The CRISPR system holds much promise for successful genome engineering, but therapeutic, industrial, and research applications will place high demand on improving the specificity and efficiency of this tool. CT-Finder (http://bioinfolab.miamioh.edu/ct-finder) is a web service to help users design guide RNAs (gRNAs) op...

journal_title：Scientific reports

authors： Zhu H,Misel L,Graham M,Robinson ML,Liang C

更新日期：2016-05-23 00:00:00

abstract：:Recent advances in the HMP (human microbiome project) research have revealed profound implications of the human microbiome to our health and diseases. We postulated that there should be distinctive features associated with healthy and/or diseased microbiome networks. Following Occam's razor principle, we further hypot...

journal_title：Scientific reports

authors： Ma ZS,Ye D

更新日期：2017-10-16 00:00:00

abstract：:Post-operative atrial fibrillation (POAF) is postulated as a complex interaction of different pathogenic factors, suggesting inflammatory processes as a main trigger of this particular type of atrial fibrillation. Therefore, the study sought to assess the impact of cellular immunity on the development of POAF. Compari...

journal_title：Scientific reports

authors： Sulzgruber P,Thaler B,Koller L,Baumgartner J,Pilz A,Steininger M,Schnaubelt S,Fleck T,Laufer G,Steinlechner B,Winter MP,Goliasch G,Wojta J,Niessner A

更新日期：2018-06-25 00:00:00

abstract：:Apparently mundane, amorphous nanostructures of carbon have optical properties which are as exotic as their crystalline counterparts. In this work we demonstrate a simple and inexpensive mechano-chemical method to prepare bulk quantities of self-passivated, amorphous carbon dots. Like the graphene quantum dots, the wa...

journal_title：Scientific reports

authors： Siddique AB,Pramanick AK,Chatterjee S,Ray M

更新日期：2018-06-27 00:00:00

abstract：:Bacteriophage capsids constitute icosahedral shells of exceptional stability that protect the viral genome. Many capsids display on their surface decoration proteins whose structure and function remain largely unknown. The decoration protein pb10 of phage T5 binds at the centre of the 120 hexamers formed by the major ...

journal_title：Scientific reports

authors： Vernhes E,Renouard M,Gilquin B,Cuniasse P,Durand D,England P,Hoos S,Huet A,Conway JF,Glukhov A,Ksenzenko V,Jacquet E,Nhiri N,Zinn-Justin S,Boulanger P

更新日期：2017-02-06 00:00:00

abstract：:Antimicrobial peptides (AMP) are highly conserved immune effectors across the tree of life and are employed as combinations. In the beetle Tenebrio molitor, a defensin and a coleoptericin are highly expressed in vivo after inoculation with S. aureus. The defensin displays strong in vitro activity but no survival benef...

journal_title：Scientific reports

authors： Makarova O,Johnston P,Rodriguez-Rojas A,El Shazely B,Morales JM,Rolff J

更新日期：2018-10-18 00:00:00

abstract：:In this article we show that diffraction segregates the polarization singularities according to their handedness. Polarization singularities are superpositions of left and right handed circular polarization vortex states. In the superposition, the component states possess different orbital angular momenta depending on...

journal_title：Scientific reports

authors： Deepa S,B S BR,Senthilkumaran P

更新日期：2019-08-28 00:00:00

abstract：:In this contribution, a complete dissertation concerning the behavior of a Long Period Grating (LPG) inscribed in a B-Ge co-doped optical fiber by means of an excimer laser and exposed to proton irradiation during a recent extensive campaign performed at the European Organization for Nuclear Research (CERN) with a flu...

journal_title：Scientific reports

authors： Berruti GM,Vaiano P,Quero G,Pimentel Das Neves TF,Boniello A,Consales M,Petagna P,Cusano A

更新日期：2020-01-28 00:00:00

abstract：:Rapid diagnostic tests (RDTs) have been widely deployed in low-resource settings. These tests are typically read by visual inspection, and accurate record keeping and data aggregation remains a substantial challenge. A successful malaria elimination campaign will require new strategies that maximize the sensitivity of...

journal_title：Scientific reports

authors： Scherr TF,Gupta S,Wright DW,Haselton FR

更新日期：2016-06-27 00:00:00

abstract：:HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of the interaction, l...

journal_title：Scientific reports

authors： Dard A,Jia Y,Reboulet J,Bleicher F,Lavau C,Merabet S

更新日期：2019-04-05 00:00:00

abstract：:Glaucoma is a major cause of visual impairment, and secondary glaucoma manifested as neovascular glaucoma has long been known to occur following high-dose fractionated radiation therapy. In contrast, little is known as to whether ionizing radiation exposure causes primary glaucoma, except that a single study in Japane...

journal_title：Scientific reports

authors： Bragin EV,Azizova TV,Bannikova MV,Grigoryeva ES,Hamada N

更新日期：2019-08-28 00:00:00