Abscopal effect of metastatic pancreatic cancer after local radiotherapy and granulocyte-macrophage colony-stimulating factor therapy.

Abstract:

:The role of immunotherapy in combination with traditional treatment regime in improving the survival of cancer patients has attracted more and more attention. Especially the abscopal effect that describes the phenomenon of localized radiotherapy leading to regression of distant unirradiated tumors and the role of enhanced radiotherapy-induced immunogenic cell death and activation of immune system have become a focus of the studies. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known a powerful stimulator of the generation, migration and activation of antigen presenting cells such as dendritic cells (DC) and macrophages. Here we report a case of a 67-year-old refractory metastatic pancreatic cancer patient who obtained evident abscopal effect and survival benefit from concurrent localized radiotherapy and GM-CSF.

journal_name

Cancer Biol Ther

journal_title

Cancer biology & therapy

authors

Shi F,Wang X,Teng F,Kong L,Yu J

doi

10.1080/15384047.2016.1276133

subject

Has Abstract

pub_date

2017-03-04 00:00:00

pages

137-141

issue

3

eissn

1538-4047

issn

1555-8576

journal_volume

18

pub_type

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