Abstract:
:The role of immunotherapy in combination with traditional treatment regime in improving the survival of cancer patients has attracted more and more attention. Especially the abscopal effect that describes the phenomenon of localized radiotherapy leading to regression of distant unirradiated tumors and the role of enhanced radiotherapy-induced immunogenic cell death and activation of immune system have become a focus of the studies. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known a powerful stimulator of the generation, migration and activation of antigen presenting cells such as dendritic cells (DC) and macrophages. Here we report a case of a 67-year-old refractory metastatic pancreatic cancer patient who obtained evident abscopal effect and survival benefit from concurrent localized radiotherapy and GM-CSF.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Shi F,Wang X,Teng F,Kong L,Yu Jdoi
10.1080/15384047.2016.1276133subject
Has Abstractpub_date
2017-03-04 00:00:00pages
137-141issue
3eissn
1538-4047issn
1555-8576journal_volume
18pub_type
杂志文章abstract::Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness,...
journal_title:Cancer biology & therapy
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abstract::Aloe-emodin is a novel active compound found in the root and rhizome of Rheum palmatum. To investigate the effects and mechanisms of aloe-emodin on human gastric cancer, MGC-803 cells were treated with 2.5, 5, 10, 20 and 40 microM aloe-emodin for 1-5 d. The results showed that aloe-emodin inhibited the growth of cance...
journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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更新日期:2009-02-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章,评审
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journal_title:Cancer biology & therapy
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doi:10.4161/cbt.6.10.4790
更新日期:2007-10-01 00:00:00
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.1080/15384047.2015.1030554
更新日期:2015-01-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.1080/15384047.2018.1423922
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journal_title:Cancer biology & therapy
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