Abscopal effect of metastatic pancreatic cancer after local radiotherapy and granulocyte-macrophage colony-stimulating factor therapy.


:The role of immunotherapy in combination with traditional treatment regime in improving the survival of cancer patients has attracted more and more attention. Especially the abscopal effect that describes the phenomenon of localized radiotherapy leading to regression of distant unirradiated tumors and the role of enhanced radiotherapy-induced immunogenic cell death and activation of immune system have become a focus of the studies. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known a powerful stimulator of the generation, migration and activation of antigen presenting cells such as dendritic cells (DC) and macrophages. Here we report a case of a 67-year-old refractory metastatic pancreatic cancer patient who obtained evident abscopal effect and survival benefit from concurrent localized radiotherapy and GM-CSF.


Cancer Biol Ther


Cancer biology & therapy


Shi F,Wang X,Teng F,Kong L,Yu J




Has Abstract


2017-03-04 00:00:00












  • KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression.

    abstract::Krüppel-Like Factor 4 (KLF4) functions as a tumor suppressor in some cancers, but its molecular mechanism is not clear. Our recent study also showed that the expression of KLF4 is dramatically reduced in primary lung cancer tissues. To investigate the possible role of KLF4 in lung cancer, we stably transfected KLF4 in...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhou Y,Hofstetter WL,He Y,Hu W,Pataer A,Wang L,Wang J,Zhou Y,Yu L,Fang B,Swisher SG

    更新日期:2010-04-01 00:00:00

  • Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells.

    abstract::We studied the mechanism of the cytotoxic activity of BZL101, an aqueous extract from the herb Scutellaria barbata D. Don, which is currently in phase II clinical trial in patients with advanced breast cancer. The phase I trial showed favorable toxicity profile and promising efficacy. We report here that BZL101 induce...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Fong S,Shoemaker M,Cadaoas J,Lo A,Liao W,Tagliaferri M,Cohen I,Shtivelman E

    更新日期:2008-04-01 00:00:00

  • Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model.

    abstract:EXPERIMENTAL DESIGN:To investigate the antitumor effect of sunitinib and FAK/Pyk2 tyrosine kinase inhibitor (PF-562,271)combination therapy in vivo, utilizing human hepatocellular carcinoma (HCC) cells Huh7.5. Nude rats were inoculated subcutaneously with Huh7.5 hepatoma cells. Dosing for Phase 1 was initiated on day 5...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Bagi CM,Christensen J,Cohen DP,Roberts WG,Wilkie D,Swanson T,Tuthill T,Andresen CJ

    更新日期:2009-05-01 00:00:00

  • c-Myc modulation: a key role in melanoma drug response.

    abstract::Understanding molecular mechanisms involved in melanoma resistance to drugs is a big challenge. Experimental evidences suggested a correlation between mutational status in B-RAF and melanoma cell susceptibility to drugs, such as paclitaxel, doxorubicin and temozolomide, which generate an accumulation of hydrogen perox...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Fico A,Alfano D,Valentino A,Vasta V,Cavalcanti E,Travali S,Patriarca EJ,Caputo E

    更新日期:2015-01-01 00:00:00

  • Heparan sulfate proteoglycans as targets for cancer therapy: a review.

    abstract::Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and progression, by interacting with the signaling pathways that affect proliferation, adhesion, invasion and angiogenesis. These roles suggest the possibility of various strategies of regulation of these molecules. In this review, we demo...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Onyeisi JOS,Ferreira BZF,Nader HB,Lopes CC

    更新日期:2020-12-01 00:00:00

  • MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.

    abstract::Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anti-cancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, causing growth arrest and subsequent cell death. Studies by a number of laboratories have...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Yacoub A,Gilfor D,Hawkins W,Park MA,Hanna D,Hagan MP,Curiel DT,Fisher PB,Grant S,Dent P

    更新日期:2006-10-01 00:00:00

  • KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia.

    abstract::KLF4 is induced upon growth-arrest in vitro and during epithelial maturation in vivo, and is essential for proper cell fate specification of post-mitotic cells. In spite of a normal role in post-mitotic cells, expression is upregulated and constitutive in certain tumor types. KLF4 functions as an oncogene in vitro, an...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Huang CC,Liu Z,Li X,Bailey SK,Nail CD,Foster KW,Frost AR,Ruppert JM,Lobo-Ruppert SM

    更新日期:2005-12-01 00:00:00

  • Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.

    abstract::Methylthioadenosine phosphorylase (MTAP), a key enzyme in the catabolism of 5'-deoxy-5'-methylthioadenosine (MTA), catalyzes the formation of adenine and 5-methylthioribose-1-phosphate. MTAP is expressed in all cells throughout the body, but a significant percentage of human tumors have lost MTAP expression, thereby m...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Tang B,Testa JR,Kruger WD

    更新日期:2012-09-01 00:00:00

  • MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2.

    abstract::Several microRNAs (miRNA) have been implicated in H. pylori related gastric cancer (GC). However, the molecular mechanism of miRNAs in gastric cancer has not been fully understood. In this study, we reported that miR-101 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhou X,Xia Y,Li L,Zhang G

    更新日期:2015-01-01 00:00:00

  • SUMO in cancer--wrestlers wanted.

    abstract::SUMO (small ubiquitin-related modifier) represents a class of ubiquitin-like proteins that is conjugated, like ubiquitin, by a set of enzymes to cellular regulatory proteins, including oncogenes and tumor suppressor genes, that play key roles in the control of cell growth, differentiation and apoptosis. SUMO conjugati...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Alarcon-Vargas D,Ronai Z

    更新日期:2002-05-01 00:00:00

  • Randomized discontinuation trial of sorafenib (BAY 43-9006).

    abstract::With the increasing interest in development of cytostatic anticancer drugs, the randomized discontinuation trial (RDT) design has been proved to be useful in the evaluation of their clinical activity. In the June 1, 2006 issue of the Journal of Clinical Oncology, a study by Ratain et al. uses RDT in a phase-II placebo...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,随机对照试验


    authors: Jain L,Venitz J,Figg WD

    更新日期:2006-10-01 00:00:00

  • Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.

    abstract::The present studies have examined approaches to suppress MCL-1 function in breast cancer cells, as a means to promote tumor cell death. Treatment of breast cancer cells with CDK inhibitors (flavopiridol; roscovitine) enhanced the lethality of the ERBB1 inhibitor lapatinib in a synergistic fashion. CDK inhibitors inter...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Mitchell C,Yacoub A,Hossein H,Martin AP,Bareford MD,Eulitt P,Yang C,Nephew KP,Dent P

    更新日期:2010-11-01 00:00:00

  • Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death.

    abstract::Activation of MAP kinases is involved in various cellular processes, including immunoregulation, inflammation, cell growth, cell differentiation, and cell death. To investigate the role of p38 MAP kinase activation in the signaling pathway of TRAIL-mediated apoptosis, we compared TRAIL-mediated MAP kinase activation i...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Zhang L,Zhu H,Davis JJ,Jacob D,Wu S,Teraishi F,Gutierrez A,Wang Y,Fang B

    更新日期:2004-03-01 00:00:00

  • Hes1: a key role in stemness, metastasis and multidrug resistance.

    abstract::Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Recent studies have shown that Hes1 functions in the maintenance of cancer stem cells (CSCs)...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Liu ZH,Dai XM,Du B

    更新日期:2015-01-01 00:00:00

  • Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity.

    abstract::Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of h...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Pattison AM,Barton JR,Entezari AA,Zalewski A,Rappaport JA,Snook AE,Waldman SA

    更新日期:2020-09-01 00:00:00

  • The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells.

    abstract::The cancer stem cell hypothesis suggests that rare populations of tumor-initiating cells may be resistant to therapy, lead to tumor relapse and contribute to poor prognosis for cancer patients. We previously demonstrated the feasibility of p53 pathway restoration in p53-deficient tumor cell populations using small mol...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Huang C,Zhang XM,Tavaluc RT,Hart LS,Dicker DT,Wang W,El-Deiry WS

    更新日期:2009-11-01 00:00:00

  • Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis.

    abstract::Advanced melanoma is the most virulent form of cancer and has a poor prognosis. In a previous study, myriocin, an inhibitor of serine palmitoyltransferase, was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Lee YS,Choi KM,Lee S,Sin DM,Lim Y,Lee YM,Hong JT,Yun YP,Yoo HS

    更新日期:2012-01-15 00:00:00

  • The Par-4-GRP78 TRAIL, more twists and turns.

    abstract::GRP78, also referred to as BiP, is an essential molecular chaperone and a master regulator of the unfolded protein response. Traditionally, GRP78 is regarded as localized in the lumen of the endoplasmic reticulum (ER). However, recent findings revealed that a subfraction of GRP78 can localize to the surface of specifi...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Lee AS

    更新日期:2009-11-01 00:00:00

  • Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells.

    abstract::Non-small cell lung cancer (NSCLC) remains recalcitrant to effective treatment due to tumor relapse and acquired resistance. Cancer stem cells (CSCs) are believed to be one mechanism for relapse and resistance and are consequently considered promising drug targets. We report that chetomin, an active component of Chaet...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Min S,Wang X,Du Q,Gong H,Yang Y,Wang T,Wu N,Liu X,Li W,Zhao C,Shen Y,Chen Y,Wang X

    更新日期:2020-08-02 00:00:00

  • Cancer mortality trends between 1988 and 2009 in the metropolitan area of Naples and Caserta, Southern Italy: Results from a joinpoint regression analysis.

    abstract::Mortality data by geographic area and trend-based surveillance are particularly relevant in orienting public health decisions targeting specific populations. We analyzed overall and site-specific cancer mortality between 1988 and 2009 in the metropolitan area of Naples and Caserta in southern Italy. Age-standardized m...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Crispo A,Barba M,Malvezzi M,Arpino G,Grimaldi M,Rosso T,Esposito E,Sergi D,Ciliberto G,Giordano A,Montella M

    更新日期:2013-12-01 00:00:00

  • Inhibiting gastric cancer-associated angiogenesis by CIAPIN1 siRNA.

    abstract::Angiogenesis plays an essential role in tumor growth and metastasis and is a promising target for cancer therapy. We characterized the effects of selective CIAPIN1 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of CIAPIN1 siRNA. Our study has been shown that CIAPIN1 play the det...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Yan K,He LJ,Cheng W,Ji ZZ,Zhao BX,Hui XL,Cao SS,Chen B,He L,Liang SH,Miao Y

    更新日期:2009-06-01 00:00:00

  • Pancreatic and bile duct cancer circulating tumor cells (CTC) form immune-resistant multi-cell type clusters in the portal venous circulation.

    abstract::Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze the essential inter...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Arnoletti JP,Fanaian N,Reza J,Sause R,Almodovar AJ,Srivastava M,Patel S,Veldhuis PP,Griffith E,Shao YP,Zhu X,Litherland SA

    更新日期:2018-01-01 00:00:00

  • Development of a biomimetic peptide derived from collagen IV with anti-angiogenic activity in breast cancer.

    abstract::Breast cancer is one of the most commonly diagnosed malignancies in women. Despite the remarkable success of mammography screening and use of adjuvant systemic therapy, it is estimated that approximately 200,000 new diagnoses will be made this year and 40,000 deaths will occur due to this disease (American Cancer Soci...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Rosca EV,Koskimaki JE,Pandey NB,Wolff AC,Popel AS

    更新日期:2011-11-01 00:00:00

  • A novel bispecific antibody, BiSS, with potent anti-cancer activities.

    abstract::One of the most active fields in cancer immunotherapy is the study of bispecific antibodies, which engage immune cells to kill cancer cells. However, a variety of issues are associated with most of current bispecific antibody formats. In this study, we present a novel bispecific antibody, BiSS (Bispecific antibody wit...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Dong B,Zhou C,He P,Li J,Chen S,Miao J,Li Q,Wang Z

    更新日期:2016-04-02 00:00:00

  • Epigenetic changes activate widespread signals in response to double-strand breaks.

    abstract::Double-strand breaks are one the most severe types of DNA damage with respect to cell survival and the preservation of genomic integrity. Therefore, cells have evolved complex mechanisms including cell cycle regulation, activation of repair pathways and in certain cases induction of apoptosis in response to these lesi...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Karagiannis TC,El-Osta A

    更新日期:2004-07-01 00:00:00

  • Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT.

    abstract::The Chemohormonal Therapy vs Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) was a randomized phase III trial that evaluated the outcomes of men with metastatic prostate cancer who received castration with or without docetaxel. Patients from this trial were genotyped in a recent ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Handy WF,Schmidt KT,Price DK,Figg WD

    更新日期:2020-09-01 00:00:00

  • Managing bone complications of solid tumors.

    abstract::Bone metastases are a common occurrence in patients with breast cancer, lung cancer and prostate cancer. Bone metastases cause considerable morbidity including pain, impaired mobility, pathologic fracture, spinal cord or nerve root compression, bone marrow infiltration and hypercalcemia of malignancy. These complicati...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Berenson JR,Rajdev L,Broder M

    更新日期:2006-09-01 00:00:00

  • The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein.

    abstract::CP-31398, a styrylquinazoline, emerged from a screen for therapeutic agents that restore a wild-type DNA-binding conformation of mutant p53 to suppress tumors in-vivo (Science 286, 2507, 1999). We investigated the growth inhibitory mechanism of CP-31398 using nine human cancer cell lines containing wild-type, mutant o...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Takimoto R,Wang W,Dicker DT,Rastinejad F,Lyssikatos J,el-Deiry WS

    更新日期:2002-01-01 00:00:00

  • Translational research in bladder cancer: from molecular pathogenesis to useful tissue biomarkers.

    abstract::Current risk stratification using clinical and pathological parameters in patients with urothelial carcinoma of the bladder (UCB) is insufficient. Additional information on the tumor biology can be derived from molecular biomarkers assessed in surgical UCB specimens and the predictive accuracy of oncologic end points ...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章,评审


    authors: Bolenz C,Lotan Y

    更新日期:2010-09-01 00:00:00

  • Microarray data simulator for improved selection of differentially expressed genes.

    abstract::The development of microarray technology has allowed researchers to measure expression levels of thousands of genes simultaneously. Analysis of these data requires the best normalization and statistical approaches to account for the biological and technical variability inherent in the technique. To approach this probl...

    journal_title:Cancer biology & therapy

    pub_type: 杂志文章


    authors: Singhal S,Kyvernitis CG,Johnson SW,Kaiser LR,Liebman MN,Albelda SM

    更新日期:2003-07-01 00:00:00