Pancreatic and bile duct cancer circulating tumor cells (CTC) form immune-resistant multi-cell type clusters in the portal venous circulation.

abstract：:Vitamin D derivatives can induce differentiation of human acute myeloid leukemia (AML) cells. Here, we investigated if the G₁ cell cycle block associated with monocytic differentiation is modulated by the p53 status of the cells treated with 1,25D, alone or with plant antioxidants carnosic acid (C) or silibinin (S), a...

journal_title：Cancer biology & therapy

authors： Thompson T,Danilenko M,Vassilev L,Studzinski GP

更新日期：2010-08-15 00:00:00

abstract：:Vasculogenic mimicry reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature; such has been demonstrated in aggressive ovarian carcinoma. This study measured the clinical significance of tumor cell-lined vasculature in ovarian carcinomas (n=77), which was detecte...

journal_title：Cancer biology & therapy

authors： Sood AK,Fletcher MS,Zahn CM,Gruman LM,Coffin JE,Seftor EA,Hendrix MJ

更新日期：2002-11-01 00:00:00

abstract：:The pathogenesis of sporadic colorectal cancer involves distinct pathways, with characteristic genomic alterations. The first pathway, chromosome instability (CIN), is driven by APC mutations and is typified by Kras mutations, p53 mutation/loss of heterozygosity, and deletions at chromosome 18q. The second pathway is ...

journal_title：Cancer biology & therapy

authors： Ye Y,Madison B,Wu X,Rustgi AK

更新日期：2012-12-01 00:00:00

abstract：:Gemcitabine based treatment is currently a standard first line treatment for patients with advanced pancreatic cancer, however overall survival remains poor, and few options are available for patients that fail gemcitabine based therapy. To identify potential molecular targets in gemcitabine refractory pancreatic canc...

journal_title：Cancer biology & therapy

authors： Samulitis BK,Pond KW,Pond E,Cress AE,Patel H,Wisner L,Patel C,Dorr RT,Landowski TH

更新日期：2015-01-01 00:00:00

abstract：:As a kinase at the crossroads of numerous metabolic and cell growth signaling pathways, glycogen synthase kinase-3 beta (GSK-3β) is a highly desirable therapeutic target in cancer. Despite its involvement in pathways associated with the pathogenesis of several malignancies, no selective GSK-3β inhibitor has been appro...

journal_title：Cancer biology & therapy

authors： Sahin I,Eturi A,De Souza A,Pamarthy S,Tavora F,Giles FJ,Carneiro BA

更新日期：2019-01-01 00:00:00

abstract：:Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of ...

journal_title：Cancer biology & therapy

authors： Matsubayashi H,Fukushima N,Sato N,Brune K,Canto M,Yeo CJ,Hruban RH,Kern SE,Goggins M

更新日期：2003-11-01 00:00:00

abstract：:Radiotherapy is a widely used local and regional modality for the treatment of cancer. Despite improved methods of radiation delivery, local recurrence accounts for treatment failure in most patients. Radiosensitizers have been studied as one approach for improving the effectiveness of radiotherapy. Few agents, howeve...

journal_title：Cancer biology & therapy

authors： Kufe D,Weichselbaum R

更新日期：2003-07-01 00:00:00

abstract：:Inflammation is an important factor promoting the progression of glioblastoma. In the present study we examined the contribution of Ras signaling and TNFα/IL-1β cytokines to the development of the glioblastoma inflammatory microenvironment. Enhanced activation of Ras through de-regulated activation of receptor tyrosin...

journal_title：Cancer biology & therapy

authors： Munoz L,Yeung YT,Grewal T

更新日期：2016-04-02 00:00:00

abstract：:Patients with serosal (pleural or peritoneal) spread of malignancy have few definitive treatment options and consequently have a very poor prognosis. We have previously shown that photodynamic therapy (PDT) can be an effective treatment for these patients, but that the therapeutic index is relatively narrow. Here, we ...

journal_title：Cancer biology & therapy

authors： Edmonds C,Hagan S,Gallagher-Colombo SM,Busch TM,Cengel KA

更新日期：2012-12-01 00:00:00

abstract：:5-fluorouracil forms classic (covalent, ternary) complexes consisting of thymidylate synthase, fluoro-deoxyuridine monophosphate, and 5,10-methylene tetrahydrofolate. Despite a high pharmacologic interest in the classic complexes formed in cells treated with fluorouracil anticancer agents, the in vivo stability of the...

journal_title：Cancer biology & therapy

authors： Brody JR,Gallmeier E,Yoshimura K,Hucl T,Kulesza P,Canto MI,Hruban RH,Schulick RD,Kern SE

更新日期：2006-08-01 00:00:00

abstract：:It was well known that cancer-associated fibroblasts (CAFs) were an essential factor in tumor progression. However, the actual mechanism of stromal fibroblasts activation and tumor promoting effects remain unclear. Here, we showed that KLF5 expression was more frequently observed in gastric cancer-associated fibroblas...

journal_title：Cancer biology & therapy

authors： Yang T,Chen M,Yang X,Zhang X,Zhang Z,Sun Y,Xu B,Hua J,He Z,Song Z

更新日期：2017-10-03 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is one of the most fatal hematological malignancies. APL during pregnancy is a rare comorbidity and can lead to adverse outcomes, such as maternal and/or fetal death, without timely and appropriate management. Medical management for APL during pregnancy remains challenging. We report...

journal_title：Cancer biology & therapy

authors： Li H,Han C,Li K,Li J,Wang Y,Xue F

更新日期：2019-01-01 00:00:00

abstract：:Head and neck cancer arises from a series of molecular alterations progressive from dysplasia to carcinoma in situ, and finally invasive carcinoma. Risk factors associated with head and neck cancer include tobacco, alcohol and viral infection. There are genetic alterations in pre-cancerous cells that contribute to tra...

journal_title：Cancer biology & therapy

authors： Klein JD,Grandis JR

更新日期：2010-01-01 00:00:00

abstract：:Both Pten and Nras are downstream mediators of receptor tyrosine kinase activation that plays important roles in controlling cell survival and proliferation. Here, we investigated whether and how Pten loss cross-talks with Nras activation in driving liver cancer development in mice. Somatic disruption of hepatic Pten ...

journal_title：Cancer biology & therapy

authors： Gao M,Liu D

更新日期：2017-07-03 00:00:00

abstract：:A 67-year-old male presented with anasarca and persistent non-pruritic rash of lower extremities. Physical examination was positive for subcutaneous edema with a non-blanching rash of abdomen and lower extremities. Labs showed leukocytosis, lymphocytosis, anemia and thrombocytopenia. He also had acute kidney injury an...

journal_title：Cancer biology & therapy

authors： Wahab A,Kesari K,J Smith S,Liu Y,Barta SK

更新日期：2018-02-01 00:00:00

abstract：:Small-molecule inhibitors of cyclin-dependent kinases (CDKs) are known to induce cell cycle arrest and apoptosis in certain cancer cells. In order to evaluate the antitumor activity of one such inhibitor, GW8510, against human lung cancers, we analyzed the effects of GW8510 on six nonsmall cell lung cancer (NSCLC) cel...

journal_title：Cancer biology & therapy

authors： Dong F,Guo W,Zhang L,Wu S,Teraishi F,Davis JJ,Fang B

更新日期：2006-02-01 00:00:00

abstract：:Bone metastases are a common occurrence in patients with breast cancer, lung cancer and prostate cancer. Bone metastases cause considerable morbidity including pain, impaired mobility, pathologic fracture, spinal cord or nerve root compression, bone marrow infiltration and hypercalcemia of malignancy. These complicati...

journal_title：Cancer biology & therapy

authors： Berenson JR,Rajdev L,Broder M

更新日期：2006-09-01 00:00:00

abstract：:Angiogenesis inhibitors belong to a new class of drugs. Many of these drugs are in clinical trials to treat cancer, while others have recently received FDA approval. However, angiogenesis inhibitors operate by different mechanisms than conventional cytotoxic chemotherapies, and require different guidelines for their o...

journal_title：Cancer biology & therapy

authors： Folkman J

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:Germ-line mutations of the APC gene are associated with familial adenomatous polyposis, and somatic mutations occur frequently in sporadic colorectal cancer. However, to abrogate APC function, both alleles must be inactivated. Recently, it has been demonstrated that epigenetic modification of the APC promo...

journal_title：Cancer biology & therapy

authors： Arnold CN,Goel A,Niedzwiecki D,Dowell JM,Wasserman L,Compton C,Mayer RJ,Bertagnolli MM,Boland CR

更新日期：2004-10-01 00:00:00

abstract：:To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was perf...

journal_title：Cancer biology & therapy

authors： Lee JS,Fackler MJ,Teo WW,Lee JH,Choi C,Park MH,Yoon JH,Zhang Z,Argani P,Sukumar S

更新日期：2008-09-01 00:00:00

abstract：:TPCK is widely used as an inhibitor of chymotrypsin-like proteases but has recently been identified as an inhibitor of the PDK1/Akt pathway. In this study, we show that TPCK inhibits TRAIL-induced caspase activity but potentiates wortmannin-dependent caspase activity in prostatic carcinoma cell lines. The inhibitory a...

journal_title：Cancer biology & therapy

authors： Rokhlin OW,Guseva NV,Taghiyev AF,Glover RA,Cohen MB

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:It has recently been suggested that overexpression of palladin in sporadic pancreatic cancer may contribute to pancreatic cancer's invasive and migratory abilities. This hypothesis was based on reverse transcriptase-polymerase chain reaction analyses of bulk pancreatic tissue, yet pancreatic cancer is a comp...

journal_title：Cancer biology & therapy

authors： Salaria SN,Illei P,Sharma R,Walter KM,Klein AP,Eshleman JR,Maitra A,Schulick R,Winter J,Ouellette MM,Goggins M,Hruban R

更新日期：2007-03-01 00:00:00

abstract：:Hepatoblastoma (HB) is the most common liver tumor of childhood, usually occurring in children under the age of 3 y. The prognosis of patients presenting with distant metastasis, vascular invasion and advanced tumor stages remains poor and children that do survive often face severe late effects from the aggressive che...

journal_title：Cancer biology & therapy

authors： Beck A,Eberherr C,Hagemann M,Cairo S,Häberle B,Vokuhl C,von Schweinitz D,Kappler R

更新日期：2016-11-01 00:00:00

abstract：:Resistance of tumors due to restricted drug accumulation and reversal of DNA lesions in tumor cells as well as normal tissue toxicity limit the efficacy of topoisomerase inhibition based anticancer drugs. It has been proposed that selective inhibition of energy dependent repair processes and enhanced retention of drug...

journal_title：Cancer biology & therapy

authors： Dwarakanath BS,Khaitan D,Ravindranath T

更新日期：2004-09-01 00:00:00

abstract：:Microtubule-active drugs, including paclitaxel (Taxol, PTX), cause mitotic arrest, and this can result in apoptosis. A recently study has reported that PTX mediates apoptosis by upregulating FasL in Jurkat and MDA-231 cells. In contrast to the previous report, we found that anti-FasL antibodies failed to inhibit PTX-i...

journal_title：Cancer biology & therapy

authors： Blagosklonny MV,Robey R,Sheikh MS,Fojo T

更新日期：2002-03-01 00:00:00

abstract：:We previously reported that the mutant virus of HSV (mtHSV) mediated tumor therapy was efficacious in Balb/c and nude mice. However, it is significant to know whether mtHSV works in HSV-1 tumor seropositive individuals because many patients with HSV-1 seropositivity have been found in clinical trial. Here we asked whe...

journal_title：Cancer biology & therapy

authors： Zhu H,Su Y,Zhou S,Xiao W,Ling W,Hu B,Liu Y,Qi Y

更新日期：2007-05-01 00:00:00

abstract：:Alterations in the function of cell cycle checkpoints are frequently detected in oral squamous cell carcinomas (OSCCs), and are often associated with the sensitivity of the cancer cells to chemotherapeutic drugs. Recently, a mitotic checkpoint gene, Chfr, was shown to be inactivated by promoter methylation and point m...

journal_title：Cancer biology & therapy

authors： Ogi K,Toyota M,Mita H,Satoh A,Kashima L,Sasaki Y,Suzuki H,Akino K,Nishikawa N,Noguchi M,Shinomura Y,Imai K,Hiratsuka H,Tokino T

更新日期：2005-07-01 00:00:00

abstract：:Cytotoxic chemotherapeutic drugs, especially when used in combination, are widely employed to treat a variety of cancers in patients but often lead to serious symptoms that negatively affect physical functioning and quality of life. There is compelling evidence that implicates cytotoxic chemotherapy-induced inflammati...

journal_title：Cancer biology & therapy

authors： Wong J,Tran LT,Magun EA,Magun BE,Wood LJ

更新日期：2014-10-01 00:00:00

abstract：:In a recent issue of Cancer Biology & Therapy, Vitale et al. introduced the paper of Franco et al. reporting the expression of GPER (a seven-transmembrane-spanning receptor also known as GPR30) on testicular germ cell tumors (TGCTs). The paper commented on the possible pathophysiological role of this G-protein-coupled...

journal_title：Cancer biology & therapy

authors： Chevalier N,Bouskine A,Fenichel P

更新日期：2011-07-01 00:00:00

abstract：:Sirtuins (SIRT) are nicotinamide adenine dinucleotide (NAD+) dependent deacetylases or ADP- ribosyl transferases (ARTs) that deacetylate lysine residues on various proteins regulating a variety of cellular and metabolic processes. These enzymes regulate metabolism, cell survival, differentiation and DNA repair. SIRT p...

journal_title：Cancer biology & therapy

authors： Bhalla S,Gordon LI

更新日期：2016-01-01 00:00:00