Abstract:
:Bone metastases are a common occurrence in patients with breast cancer, lung cancer and prostate cancer. Bone metastases cause considerable morbidity including pain, impaired mobility, pathologic fracture, spinal cord or nerve root compression, bone marrow infiltration and hypercalcemia of malignancy. These complications result from the derangement of normal bone metabolism that arise from interactions between factors originating in tumor cells and others originating in the microenvironment of the bone. Fortunately, there is an increasing array of treatment options for the skeletal complications associated with bone metastases arising from breast, lung, and prostate cancer. The goals of treatment for such skeletal complications are to relieve pain and reduce the risk of fracture. Traditional therapies to treat skeletal malignancies include radiation, surgery, and chemotherapy. In recent years, bisphosphonates have become the treatment of choice because of their ability to reduce bone resorption, leading to decreases in hypercalcemia, new osteolytic lesions, and fractures, thereby ameliorating pain and improving quality of life.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Berenson JR,Rajdev L,Broder Mdoi
10.4161/cbt.5.9.3308subject
Has Abstractpub_date
2006-09-01 00:00:00pages
1086-9issue
9eissn
1538-4047issn
1555-8576pii
3308journal_volume
5pub_type
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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journal_title:Cancer biology & therapy
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更新日期:2015-01-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2011-02-15 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2013-02-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章
doi:10.4161/cbt.9.10.11588
更新日期:2010-05-15 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.1080/15384047.2020.1739952
更新日期:2020-06-02 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
doi:10.4161/cbt.1.1.35
更新日期:2002-01-01 00:00:00
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journal_title:Cancer biology & therapy
pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2007-03-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2013-11-01 00:00:00
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journal_title:Cancer biology & therapy
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更新日期:2009-11-01 00:00:00
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更新日期:2003-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-12-15 00:00:00